The effect of vascular bubbles on endothelial function
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The purpose of the study was to: • Study the effect of vascular gas bubbles on the brain and lung • Study changes in the endothelial function caused by gas bubbles • Study the preventive effects of monoclonal anti-C5a antibody on functional changes caused by gas bubbles It is important to reveal any changes in the function of the endothelium caused by gas bubbles, as the endothelium probably plays an important role in the development of decompression sickness (DCS). Furthermore, we followed up previous studies using monoclonal anti-C5a antibody trying to prevent damages caused by gas bubbles. In order to prevent damages causes by gas bubbles and maybe prevent DCS, the mechanisms behind have to be revealed. This thesis is part of an ongoing project that for several years has tried to bring to light the “secrets” of DCS.
Består avNossum, Vibeke; Koteng, S.; Brubakk, A.O.. Endothelial damage by bubbles in the pulmonary artery of the pig. UNDERSEA & HYPERBARIC MEDICINE. 26(1): 1-8, 1999.
Hjelde, A.; Nossum, Vibeke; Steinsvik, M.; Bagstevold, J.I.; Brubakk, A.O.. Evaluation of cerebral gas retention and oedema formation in decompressed rats by using a simple gravimetric method. Scandinavian Journal of Clinical and Laboratory Investigation. 62(4): 263-270, 2002.
Nossum, Vibeke; Hjelde, A.; Brubakk, A.O.. Small amounts of venous gas embolism cause delayed impairment of endothelial function and increase polymorphonuclear neutrophil infiltration. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. 86(3): 209-214, 2002.
Nossum, Vibeke; Hjelde, A.; Bergh, K.; Brubakk, A.O.. Lack of effect of anti-C5a monoclonal antibody on endothelial injury by gas bubbles in the rabbit after decompression. UNDERSEA & HYPERBARIC MEDICINE. 27(1): 27-35, 2000.
Nossum, Vibeke; Hjelde, A.; Bergh, K.; Ustad, A-L; Brubakk, A.O.. Anti-C5a monoclonal antibodies and pulmonary polymorphonuclear leukocyte infiltration - endothelial dysfunction by venous gas embolism. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. 89(3-4): 243-248, 2003.