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dc.contributor.authorUrsin, Kristin
dc.contributor.authorLydersen, Stian
dc.contributor.authorSkomsvoll, Johan Fredrik
dc.contributor.authorWallenius, Marianne
dc.date.accessioned2020-03-05T08:19:08Z
dc.date.available2020-03-05T08:19:08Z
dc.date.created2019-09-13T14:16:19Z
dc.date.issued2019
dc.identifier.citationArthritis care & research. 2019, 71 (8), 1092-1100.nb_NO
dc.identifier.issn2151-464X
dc.identifier.urihttp://hdl.handle.net/11250/2645381
dc.description.abstractObjective To study disease activity in women with peripheral psoriatic arthritis (PsA) during and after pregnancy. Previous knowledge on this topic is sparse. Methods The study included 108 pregnancies in 103 women with PsA from a Norwegian nationwide register. Disease activity was assessed prospectively at 7 time points before, throughout, and after pregnancy with the 3‐variable Disease Activity Score in 28 joints (DAS28) using C‐reactive protein levels and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Scores assessed at each time point were analyzed in a linear mixed model. We did additional analyses with “tumor necrosis factor inhibitor (TNFi) in pregnancy” as a covariate. The same statistical method was used to study self‐reported physical function, pain, and mental health. Results Approximately 75% of the women were in remission or had low disease activity during and after pregnancy according to the DAS28‐CRP score. Although disease activity was altogether stable, we found that it decreased in pregnancy and increased within 6 months postpartum. Disease activity at 6 months postpartum was significantly higher than at 6 weeks postpartum (mean DAS28‐CRP score 2.71 versus 2.45; P = 0.016). Women using TNFi in pregnancy had significantly lower disease activity than women not using TNFi (mean DAS28‐CRP score at 6 months postpartum 2.22 versus 2.72; P = 0.043). BASDAI scores were also low and stable during pregnancy but significantly higher at 6 months postpartum than at 6 weeks postpartum (mean BASDAI score 3.69 versus 2.95; P = 0.013). Conclusion Studying women with PsA, we found that disease activity was highest at 6 months postpartum but altogether low and stable in the period from planning pregnancy to 1 year after delivery. Women using TNFi in pregnancy had significantly lower disease activity.nb_NO
dc.language.isoengnb_NO
dc.publisherWileynb_NO
dc.titlePsoriatic arthritis disease activity during and after pregnancy: A prospective multicenter studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber1092-1100nb_NO
dc.source.volume71nb_NO
dc.source.journalArthritis care & researchnb_NO
dc.source.issue8nb_NO
dc.identifier.doi10.1002/acr.23747
dc.identifier.cristin1724518
dc.description.localcodeThis is the peer reviewed version of an article, which has been published in final form at [https://doi.org/10.1002/acr.23747]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.nb_NO
cristin.unitcode194,65,30,0
cristin.unitcode1920,15,0,0
cristin.unitcode194,65,35,5
cristin.unitcode1920,26,0,0
cristin.unitcode1920,9,0,0
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap
cristin.unitnameMedisinsk klinikk
cristin.unitnameRKBU Midt-Norge - Regionalt kunnskapssenter for barn og unge - psykisk helse og barnevern
cristin.unitnameSentral stab
cristin.unitnameKlinikk for ortopedi, revmatologi og hudsykdommer
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2


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