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dc.contributor.authorMartinsen, Tom Christian
dc.contributor.authorFossmark, Reidar
dc.contributor.authorWaldum, Helge
dc.date.accessioned2020-02-27T09:18:53Z
dc.date.available2020-02-27T09:18:53Z
dc.date.created2020-01-02T10:07:05Z
dc.date.issued2019
dc.identifier.citationInternational Journal of Molecular Sciences. 2019, 20:6031 (23), 1-22.nb_NO
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/11250/2644105
dc.description.abstractGastric juice is a unique combination of hydrochloric acid (HCl), lipase, and pepsin. Acidic gastric juice is found in all vertebrates, and its main function is to inactivate microorganisms. The phylogenetic preservation of this energy-consuming and, at times, hazardous function (acid-related diseases) reflects its biological importance. Proton pump inhibitors (PPIs) are one of the most widely used drugs in the world. Due to the reduced prevalence of Helicobacter pylori infection as well as the increased use of inhibitors of gastric acid secretion, the latter has become the most important cause of gastric hypoacidity. In the present manuscript, we review the microbiological consequences of removing gastric acidity. The resulting susceptibility to infections has not been studied extensively, and focus has mainly been restricted to bacterial and parasitic agents only. The strongest evidence concerning the relationship between hypochlorhydria and predisposition to infections relates to bacterial infections affecting the gastrointestinal tract. However, several other clinical settings with increased susceptibility to infections due to inhibited gastric acidity are discussed. We also discuss the impact of hypochlorhydria on the gut microbiome.nb_NO
dc.language.isoengnb_NO
dc.publisherMDPInb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleThe phylogeny and biological function of gastric juice-microbiological consequences of removing gastric acidnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber1-22nb_NO
dc.source.volume20:6031nb_NO
dc.source.journalInternational Journal of Molecular Sciencesnb_NO
dc.source.issue23nb_NO
dc.identifier.doi10.3390/ijms20236031
dc.identifier.cristin1764943
dc.description.localcodeThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citednb_NO
cristin.unitcode194,65,15,0
cristin.unitcode1920,15,0,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameMedisinsk klinikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal