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dc.contributor.authorNyberg, Jenny
dc.contributor.authorGustavsson, Sara
dc.contributor.authorLinde, Mattias
dc.contributor.authorÅberg, N David
dc.contributor.authorRohmann, Jessica L
dc.contributor.authorÅberg, Maria
dc.contributor.authorKurth, Tobias
dc.contributor.authorWaern, Margda
dc.contributor.authorKuhn, Georg Hans
dc.identifier.citationBMJ Open. 2019, 9 (8), 1-9.nb_NO
dc.description.abstractObjectives: To examine the longitudinal relationship between cardiovascular fitness in young adult men and future risk of migraine and to estimate eventual differential effects among categories of body mass index (BMI) and blood pressure. Design: National, prospective, population-based cohort study. Setting: Sweden 1968–2014. Participants: 18-year-old Swedish men (n=1 819 828) who underwent mandatory military conscription examinations during the years 1968–2005. Primary and secondary outcomes: The primary outcome was the first dispensation of prescribed migraine-specific medication, identified using the Swedish Prescribed Drug Register. The secondary outcome was documented migraine diagnosis from the Swedish National Hospital Register. Results: During follow-up, 22 533 men filled a prescription for migraine-specific medication. After confounding adjustment, compared with high cardiovascular fitness, low and medium fitness increased the risk of migraine-specific medication (risk ratio (RR)low: 1.29, 95% CI 1.24 to 1.35; population attributable fraction: 3.6%, 95% CI 1.7% to 5.3% and RRmedium: 1.15, 95% CI 1.12 to 1.19; population attributable fraction: 8.0%, 95% CI 4.0% to 11.7%). To assess potential effect measure modification, stratified analyses of these association by levels of BMI and blood pressure showed that lower fitness levels increased risk of migraine across all groups except among underweight men or men with high diastolic blood pressure. Conclusions: Young men with a lower cardiovascular fitness had a higher long-term risk of developing pharmacological prescription-requiring migraine. This study contributes with information regarding risk factors for migraine in men, an understudied population in migraine research.nb_NO
dc.publisherBMJ Publishing Groupnb_NO
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titleCardiovascular fitness and risk of migraine: A large, prospective population-based study of Swedish young adult mennb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalBMJ Opennb_NO
dc.description.localcode© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:
cristin.unitnameNasjonal kompetansetjeneste for hodepine
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal