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dc.contributor.authorLetnes, Jon Magne
dc.contributor.authorNes, Bjarne
dc.contributor.authorVaardal-Lunde, Kristina
dc.contributor.authorBratt Slette, Martine
dc.contributor.authorMølmen, Harald Edvard
dc.contributor.authorAspenes, Stian Thoresen
dc.contributor.authorStøylen, Asbjørn
dc.contributor.authorWisløff, Ulrik
dc.contributor.authorDalen, Håvard
dc.date.accessioned2020-02-06T13:32:52Z
dc.date.available2020-02-06T13:32:52Z
dc.date.created2020-02-01T13:50:15Z
dc.date.issued2020
dc.identifier.issn2047-9980
dc.identifier.urihttp://hdl.handle.net/11250/2640073
dc.description.abstractBackground Left atrial (LA) size and cardiorespiratory fitness (CRF) are predictors of future cardiovascular events in high‐risk populations. LA dilatation is a diagnostic criterion for left ventricular diastolic dysfunction. However, LA is dilated in endurance athletes with high CRF, but little is known about the association between CRF and LA size in healthy, free‐living individuals. We hypothesized that in a healthy population, LA size was associated with CRF and leisure‐time physical activity, but not with echocardiographic indexes of left ventricular diastolic dysfunction. Methods and Results In this cross‐sectional study from HUNT (Nord‐Trøndelag Health Study), 107 men and 138 women, aged 20 to 82 years, without hypertension, cardiovascular, pulmonary, or malignant disease participated. LA volume was assessed by echocardiography and indexed to body surface area LAVI (left atrial volume index). CRF was measured as peak oxygen uptake (VO2peak) using ergospirometry, and percent of age‐ and‐sex‐predicted VO2peak was calculated. Indexes of left ventricular diastolic dysfunction were assessed in accordance with latest recommendations. LAVI was >34 mL/m2 in 39% of participants, and LAVI was positively associated with VO2peak and percentage of age‐ and‐sex‐predicted VO2peak (β [95% CI], 0.11 [0.06–0.16] and 0.18 [0.09–0.28], respectively) and weighted minutes of physical activity per week (β [95% CI], 0.01 [0.003–0.015]). LAVI was not associated with other indexes of left ventricular diastolic dysfunction. There was an effect modification between age and VO2peak/percentage of age‐ and‐sex‐predicted VO2peak showing higher LAVI with advanced age and higher VO2peak/percentage of age‐ and‐sex‐predicted VO2peak as presented in prediction diagrams. Conclusions Interpretation of LAVI as a marker of diastolic dysfunction should be done in relation to age‐relative CRF. Studies on the prognostic value of LAVI in fit subpopulations are needed.nb_NO
dc.language.isoengnb_NO
dc.publisherWiley Open Accessnb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleLeft Atrial Volume, Cardiorespiratory Fitness, and Diastolic Function in Healthy Individuals: The HUNT Study, Norwanb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.volume9nb_NO
dc.source.journalJournal of the American Heart Associationnb_NO
dc.source.issue3nb_NO
dc.identifier.doihttps://doi.org/10.1161/JAHA.119.014682
dc.identifier.cristin1789554
dc.description.localcode© 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative CommonsAttribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.nb_NO
cristin.unitcode194,65,25,0
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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