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dc.contributor.authorMeltzer, Sebastian
dc.contributor.authorBakke, Kine Mari
dc.contributor.authorRød, Karina Lund
dc.contributor.authorNegård, Anne
dc.contributor.authorFlatmark, Kjersti
dc.contributor.authorSolbakken, Arne Mide
dc.contributor.authorKristensen, Annette Torgunrud
dc.contributor.authorFuglestad, Anniken Jørlo
dc.contributor.authorKersten, Christian
dc.contributor.authorDueland, Svein
dc.contributor.authorSeierstad, Therese
dc.contributor.authorHole, Knut Håkon
dc.contributor.authorLyckander, Lars Gustav
dc.contributor.authorLarsen, Finn Ole
dc.contributor.authorSchou, Jakob Vasehus
dc.contributor.authorBrown, Dawn
dc.contributor.authorAbrahamsson, Hanna Josefine
dc.contributor.authorRedalen, Kathrine
dc.contributor.authorRee, Anne Hansen
dc.identifier.citationClinical and Translational Radiation Oncology. 2019, 21 5-10.nb_NO
dc.description.abstractBackground and purpose We investigated how features relating to pelvic cavity anatomy and tumor hemodynamic factors may influence systemic failure in rectal cancer. Materials and methods Rectal cancer patients (207 women, 343 men), who had been prospectively enrolled onto six cohorts and given curative-intent therapy, were analyzed for the first metastatic event. In one of the cohorts, the diameter of the inferior mesenteric vein (IMV) was assessed on diagnostic abdominal computed tomography images (n = 113). Tumor volume (n = 193) and histologic response to neoadjuvant therapy (n = 445) were recorded from diagnostic magnetic resonance images and surgical specimens, respectively. Results More women than men developed lung metastasis (p = 0.037), while the opposite was the case for liver metastasis (p = 0.040). Wider IMV diameter correlated with larger tumor volume (r = 0.481, p < 0.001) and male sex (p < 0.001). Female sex was the only adverse prognostic factor for lung metastasis. When sex, tumor volume, and histologic response were taken into consideration, poor tumor response remained the only determinant for liver metastasis (p = 0.002). Conclusions In a diverse rectal cancer population given curative-intent treatment, women and men had different outcome with regard to the primary metastatic site. Tumor hemodynamic factors should be considered in rectal cancer risk stratification.nb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleSex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors?nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalClinical and Translational Radiation Oncologynb_NO
dc.description.localcode(C) 2019 The Author(s). Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology. This is an open access article under the CC BY-NC-ND license ( licenses/by-nc-nd/4.0/).nb_NO
cristin.unitnameNorges teknisk-naturvitenskapelige universitet

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal