dc.contributor.author | Husebye, Elisabeth Synnøve Nilsen | |
dc.contributor.author | Gilhus, Nils Erik | |
dc.contributor.author | Spigset, Olav | |
dc.contributor.author | Daltveit, Anne Kjersti | |
dc.contributor.author | Bjørk, Marte-Helene | |
dc.date.accessioned | 2020-01-16T14:33:18Z | |
dc.date.available | 2020-01-16T14:33:18Z | |
dc.date.created | 2020-01-14T18:18:32Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | European Journal of Neurology. 2019, . | nb_NO |
dc.identifier.issn | 1351-5101 | |
dc.identifier.uri | http://hdl.handle.net/11250/2636690 | |
dc.description.abstract | Background and purpose
The purpose was to examine the consequences of antiepileptic drug (AED) exposure during pregnancy on language abilities in children aged 5 and 8 years of mothers with epilepsy.
Methods
The study population included children of mothers with and without epilepsy enrolled in the Norwegian Mother and Child Cohort Study 1999–2008. Mothers prospectively provided information on epilepsy diagnosis, AED use during pregnancy and the child’s language abilities at age 5 and 8 years, in questionnaires with validated language screening tools. AED concentrations in gestation week 17–19 and in the umbilical cord were measured.
Results
The study population included 346 AED‐exposed and 388 AED‐unexposed children of mothers with epilepsy, and 113 674 children of mothers without epilepsy. Mothers of 117 and 121 AED‐exposed children responded to the questionnaires at age 5 and 8 years, respectively. For AED‐exposed children, the adjusted odds ratio for language impairment was 1.6 [confidence interval (CI) 1.1–2.5, P = 0.03] at age 5 years and 2.0 (CI 1.4–3.0, P < 0.001) at age 8 years, compared to children of mothers without epilepsy. Children exposed to carbamazepine monotherapy had a significantly increased risk of language impairment compared to control children at age 8 years (adjusted odds ratio 3.8, CI 1.6–9.0, P = 0.002). Higher maternal valproate concentrations correlated with language impairment at age 5 years. Periconceptional folic acid supplement use protected against AED‐associated language impairment.
Conclusion
Foetal AED exposure in utero is associated with an increased risk of language impairment in children aged 5 and 8 years of mothers with epilepsy. Periconceptional folic acid use had a protective effect on AED‐associated language impairment. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Wiley | nb_NO |
dc.rights | Navngivelse-Ikkekommersiell 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/deed.no | * |
dc.title | Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero – the Norwegian Mother and Child Cohort Study | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 9 | nb_NO |
dc.source.journal | European Journal of Neurology | nb_NO |
dc.identifier.doi | 10.1111/ene.14140 | |
dc.identifier.cristin | 1773003 | |
dc.description.localcode | © 2019 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | nb_NO |
cristin.unitcode | 194,65,15,0 | |
cristin.unitcode | 1920,0,0,0 | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.unitname | St. Olavs Hospital HF | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |