dc.contributor.author | Beckwith, Kai Sandvold | |
dc.contributor.author | Ullmann, Sindre | |
dc.contributor.author | Vinje, Jakob | |
dc.contributor.author | Sikorski, Pawel | |
dc.date.accessioned | 2020-01-14T08:57:47Z | |
dc.date.available | 2020-01-14T08:57:47Z | |
dc.date.created | 2019-09-17T13:38:13Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Small. 2019, 15 (43), 1902514-?. | nb_NO |
dc.identifier.issn | 1613-6810 | |
dc.identifier.uri | http://hdl.handle.net/11250/2636099 | |
dc.description.abstract | Surfaces decorated with high aspect ratio nanostructures are a promising tool to study cellular processes and design novel devices to control cellular behavior. However, little is known about the dynamics of cellular phenomenon such as adhesion, spreading, and migration on such surfaces. In particular, how these are influenced by the surface properties. In this work, fibroblast behavior is investigated on regular arrays of 1 µm high polymer nanopillars with varying pillar to pillar distance. Embryonic mouse fibroblasts (NIH‐3T3) spread on all arrays, and on contact with the substrate engulf nanopillars independently of the array pitch. As the cells start to spread, different behavior is observed. On dense arrays which have a pitch equal or below 1 µm, cells are suspended on top of the nanopillars, making only sporadic contact with the glass support. Cells stay attached to the glass support and fully engulf nanopillars during spreading and migration on the sparse arrays which have a pitch of 2 µm and above. These alternate states have a profound effect on cell migration rates. Dynamic F‐actin puncta colocalize with nanopillars during cell spreading and migration. Strong membrane association with engulfed nanopillars might explain the reduced migration rates on sparse arrays. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Wiley | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Influence of Nanopillar Arrays on Fibroblast Motility, Adhesion, and Migration Mechanisms | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1902514-? | nb_NO |
dc.source.volume | 15 | nb_NO |
dc.source.journal | Small | nb_NO |
dc.source.issue | 43 | nb_NO |
dc.identifier.doi | 10.1002/smll.201902514 | |
dc.identifier.cristin | 1725687 | |
dc.relation.project | Norges forskningsråd: 223255 | nb_NO |
dc.relation.project | Norges forskningsråd: 245963 | nb_NO |
dc.description.localcode | © 2019 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited | nb_NO |
cristin.unitcode | 194,65,15,0 | |
cristin.unitcode | 194,66,20,0 | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.unitname | Institutt for fysikk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |