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dc.contributor.authorSulheim, Einar
dc.contributor.authorMørch, Ýrr Asbjørg
dc.contributor.authorSnipstad, Sofie
dc.contributor.authorBorgos, Sven Even F.
dc.contributor.authorMiletic, Hrvoje
dc.contributor.authorBjerkvig, Rolf
dc.contributor.authorDavies, Catharina de Lange
dc.contributor.authorÅslund, Andreas
dc.identifier.citationNanotheranostics. 2019, 3 103-112.nb_NO
dc.description.abstractTreatment of glioblastoma and other diseases in the brain is especially challenging due to the blood-brain barrier, which effectively protects the brain parenchyma. In this study we show for the first time that cabazitaxel, a semi-synthetic derivative of docetaxel can cross the blood-brain barrier and give a significant therapeutic effect in a patient-derived orthotopic model of glioblastoma. We show that the drug crosses the blood-brain barrier more effectively in the tumor than in the healthy brain due to reduced expression of p-glycoprotein efflux pumps in the vasculature of the tumor. Surprisingly, neither ultrasound-mediated blood-brain barrier opening (sonopermeation) nor drug formulation in polymeric nanoparticles could increase either accumulation of the drug in the brain or therapeutic effect. This indicates that for hydrophobic drugs, sonopermeation of the blood brain barrier might not be sufficient to achieve improved drug delivery. Nonetheless, our study shows that cabazitaxel is a promising drug for the treatment of brain tumors.nb_NO
dc.publisherIvyspring International Publishernb_NO
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titleTherapeutic Effect of Cabazitaxel and Blood-Brain Barrier opening in a Patient-Derived Glioblastoma Modelnb_NO
dc.typeJournal articlenb_NO
dc.relation.projectNorges forskningsråd: 240316nb_NO
dc.relation.projectRegionalt helseforetak: 900000nb_NO
dc.description.localcode© Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license ( See for full terms and conditionsnb_NO
cristin.unitnameInstitutt for fysikk

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal