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dc.contributor.authorLu, Pengfei
dc.contributor.authorVeletic, Mladen
dc.contributor.authorLaasmaa, Martin
dc.contributor.authorVendelin, Marko
dc.contributor.authorLouch, William Edward
dc.contributor.authorHalvorsen, Per Steinar
dc.contributor.authorBergsland, Jacob
dc.contributor.authorBalasingham, Ilangko
dc.date.accessioned2020-01-13T10:54:13Z
dc.date.available2020-01-13T10:54:13Z
dc.date.created2019-11-27T16:32:20Z
dc.date.issued2019
dc.identifier.citationNano Communication Networks. 2019, 22:100270 1-11.nb_NO
dc.identifier.issn1878-7789
dc.identifier.urihttp://hdl.handle.net/11250/2635929
dc.description.abstractThere is continuous interest in maximizing the longevity of implantable pacemakers, which are effective in remedying and managing patients with arrhythmic heart disease. This paper accordingly first proposes miniature actuating nanomachines that inter-connect with individual cardiomyocytes and then deeply explores their energy expenditure when performing basic cardiomyocyte stimulation tasks. Since evoked electrical impulses from a number of actuated cardiomyocytes could coordinate contraction throughout the remaining heart muscle and lead to a heart beat, the miniature actuating nanomachines acting synchronously form a conceptual multi-nodal nano-actuator pacemaker network. Rectangular-, sine-, half-sine-, and sawtooth stimulation pulses with varying configurations are considered for actuation of a single isolated in-silico cardiomyocyte by each of the nanomachines. Computer optimization methods with energy consumption as a cost function are utilized to configure preferable stimulation signals in terms of numbers of stimulation sessions/pulses, pulse amplitudes, and duration. In addition, the simulation data are compared with experimental data obtained using in-vitro mouse cardiomyocytes. Among the considered waveforms, half-sine pulses that lead to actuation of a single cardiomyocyte consume minimum energy. None of the used sequences with multiple stimulation pulses reduces the overall energy expenditure of cell stimulation when compared to a single pulse stimulation.nb_NO
dc.language.isoengnb_NO
dc.publisherElseviernb_NO
dc.titleMulti-nodal nano-actuator pacemaker for energy-efficient stimulation of cardiomyocytesnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber1-11nb_NO
dc.source.volume22:100270nb_NO
dc.source.journalNano Communication Networksnb_NO
dc.identifier.doi10.1016/j.nancom.2019.100270
dc.identifier.cristin1753278
dc.description.localcode© 2019. This is the authors’ accepted and refereed manuscript to the article. Locked until 19.10.2021 due to copyright restrictions. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/nb_NO
cristin.unitcode194,63,35,0
cristin.unitnameInstitutt for elektroniske systemer
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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