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dc.contributor.advisorTorp, Sverre Helgenb_NO
dc.contributor.authorHabberstad, Andreas Hanssønnnb_NO
dc.date.accessioned2014-12-19T14:17:37Z
dc.date.available2014-12-19T14:17:37Z
dc.date.created2014-05-08nb_NO
dc.date.issued2012nb_NO
dc.identifier716268nb_NO
dc.identifier.urihttp://hdl.handle.net/11250/263297
dc.description.abstractDue to the heterogeneous histopathology of diffuse astrocytomas we wanted to investigate the frequency of various histological features in grade II tumours. Herein we present the results of amicroscopical examination and revision of 109 consecutively operated grade II tumours. The mostfrequent subtype was fibrillary astrocytoma (87%), whereas the gemistocytic and protoplasmic subtypes constituted 12% and 1% respectively. Cell density was subjectively classified and ranged fromlow to high; most cases were judged as low to moderate (approx. 90%). Cellular/nuclear atypia wasassessed as mild, moderate and severe, and was in the majority of cases mild to moderate (96%).Mitoses were observed in about 25% of the cases with a median of 0 (range 0–3). Apoptotic figures,microcystic changes, Rosenthal fibres, microcalcification and eosinophilic bodies were identified inapprox. 45%, 38%, 7%, 5% and 2% of the cases respectively. In about 60% of the cases so calledsecondary changes of Scherer were seen. Significant correlations between features related to malignancy, such as mitotic activity, apoptoses and high cell density, were established. Further, Ki-67/MIB-1 proliferation indices corresponded significantly with mitoses, apoptoses, atypia and high celldensity. Accordingly, the variegated histopathological appearance of diffuse astrocytomas makes thediagnosis of these tumours challenging. Accordingly, it is essential to know and be aware of thismorphological diversity in the daily routine. The use of Ki-67/MIB-1 immunostaining may improvethe diagnostic accuracy.nb_NO
dc.languageengnb_NO
dc.publisherNorges teknisk-naturvitenskapelige universitet, Det medisinske fakultetnb_NO
dc.subjectBrain tumours; diagnosis; gliomas; Ki-67; MIB-1.en_GB
dc.titleProliferative activity and histopathological features in diffuse grade II astrocytomasnb_NO
dc.typeMaster thesisnb_NO
dc.source.pagenumber8nb_NO
dc.contributor.departmentNorges teknisk-naturvitenskapelige universitet, Det medisinske fakultetnb_NO


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