Vis enkel innførsel

dc.contributor.authorThommesen, Livnb_NO
dc.date.accessioned2014-12-19T14:16:31Z
dc.date.available2014-12-19T14:16:31Z
dc.date.created2001-07-05nb_NO
dc.date.issued2001nb_NO
dc.identifier121768nb_NO
dc.identifier.urihttp://hdl.handle.net/11250/263087
dc.description.abstractCells in a multicellular organism depend on extensive communication with each other. Eukaryotic cells have developed elaborate signal transduction systems by which externally provided information (hormones, cytokines, growth factors, ions and other signaling molecules) is converted into intracellular information that regulates the internal workings of the cell, such as transcription of genes. This can be exemplified by gastric acid production in humans. Secretion of gastric acid is regulated by the peptide hormone gastrin, and involves an interplay between different cells in the stomach mucosa as well as induction of gene expression (Figure 1). The physiological response to food intake includes release of gastrin from G-cells. Gastrin binds to receptors on the ECL-cells and thereby induces histamine release from internal vesicles. Histamine in turn acts upon parietal cells that are stimulated to produce and secrete gastric acid. The regulatory functions of gastrin also include release of somatostatin from D-cells and induction of histidine decarboxylase (HDC) gene expression. HDC catalyses the ratelimiting step in histamine production in ECL-cells.nb_NO
dc.languageengnb_NO
dc.publisherDet medisinske fakultetnb_NO
dc.relation.ispartofseriesDissertations at the Faculty of Medicine, 0805-7680; 189nb_NO
dc.relation.haspartLægreid, A; Thommesen, L; Jahr, TG; Sundan, A; Espevik, T. Tumor Necrosis Factor Induces Lipopolysaccharide Tolerance in a Human Adenocarcinoma Cell Line Mainly through the TNF p55 Receptor (*). Journal of Biological Chemistry. 270(43): 25418-25425, 1995.nb_NO
dc.relation.haspartThommesen, L; Sjursen, W; Gåsvik, K; Hanssen, W; Brekke, O-L; Skattebøl, L; Holmeide, AK; Espevik, T; Johansen, B; Lægreid, A. Selective Inhibitors of Cytosolic or Secretory Phospholipase A2 Block TNF-Induced Activation of Transcription Factor Nuclear Factor-B and Expression of ICAM-1. J. Immunol. 161: 3421-3430, 1998.nb_NO
dc.relation.haspartThommesen, L; Nørsett, K; Sandvik, AK; Hofsli, E; Lægreid, A. Regulation of Inducible cAMP Early Repressor Expression by Gastrin and Cholecystokinin in the Pancreatic Cell Line AR42J. J. Biol. Chem. 275: 4244-4250, 2000.nb_NO
dc.titleMolecular mechanisms involved in TNF - and gastrin-mediated gene regulationnb_NO
dc.typeDoctoral thesisnb_NO
dc.source.pagenumber72nb_NO
dc.contributor.departmentNorges teknisk-naturvitenskapelige universitet, Det medisinske fakultetnb_NO
dc.description.degreeDr.philos.nb_NO
dc.description.degreeDr.philos.en_GB


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel