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dc.contributor.authorMai, Xiao-Mei
dc.contributor.authorVidem, Vibeke
dc.contributor.authorSheehan, Nuala A.
dc.contributor.authorChen, Yue
dc.contributor.authorLanghammer, Arnulf
dc.contributor.authorSun, Yi-Qian
dc.date.accessioned2019-11-19T09:42:59Z
dc.date.available2019-11-19T09:42:59Z
dc.date.created2018-11-24T10:43:08Z
dc.date.issued2018
dc.identifier.citationEuropean Journal of Epidemiology (EJE). 2018, 34 (1), 57-66.nb_NO
dc.identifier.issn0393-2990
dc.identifier.urihttp://hdl.handle.net/11250/2629228
dc.description.abstractBackground: Observational studies have shown consistent associations between higher circulating 25-hydroxyvitamin D [25(OH)D] levels and favorable serum lipids. We sought to investigate if such associations were causal. Methods: A Mendelian randomization (MR) study was conducted on a population-based cohort comprising 56435 adults in Norway. A weighted 25(OH)D allele score was generated based on vitamin D-increasing alleles of rs2282679, rs12785878 and rs10741657. Linear regression analyses of serum lipid levels on the allele score were performed to assess the presence of causal associations of serum 25(OH)D with the lipids. To quantify the causal effects, the inverse-variance weighted method was used for calculating MR estimates based on summarized data of individual single-nucleotide polymorphisms. The MR estimate with 95% confidence interval (CI) represents percentage difference in the lipid level per genetically determined 25 nmol/L increase in 25(OH)D. Results: The 25(OH)D allele score demonstrated a clear association with high-density lipoprotein (HDL) cholesterol (p=0.007) but no association with total or non-HDL cholesterol or triglycerides (p ≥0.27). The MR estimate showed 2.52% (95% CI 0.79 to 4.25%) increase in HDL cholesterol per genetically determined 25 nmol/L increase in 25(OH)D, which was stronger than the corresponding estimate of 1.83% (95% CI 0.85 to 2.81%) from the observational analysis. The MR estimates for total cholesterol (0.60%, 95% CI -0.73 to 1.94%), non-HDL cholesterol (0.04%, 95% CI -1.79 to 1.88%) and triglycerides (-2.74%, 95% CI -6.16 to 0.67%) showed no associations. Conclusions: MR analysis of data from a population-based cohort suggested a causal and positive association between serum 25(OH)D and HDL cholesterol.nb_NO
dc.description.abstractPotential causal associations of serum 25-hydroxyvitamin D with lipids: a Mendelian randomization approach of the HUNT studynb_NO
dc.language.isoengnb_NO
dc.publisherSpringer Verlagnb_NO
dc.titlePotential causal associations of serum 25-hydroxyvitamin D with lipids: a Mendelian randomization approach of the HUNT studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber57-66nb_NO
dc.source.volume34nb_NO
dc.source.journalEuropean Journal of Epidemiology (EJE)nb_NO
dc.source.issue1nb_NO
dc.identifier.doi10.1007/s10654-018-0465-x
dc.identifier.cristin1634501
dc.relation.projectKreftforeningen: 5769155-2015nb_NO
dc.description.localcodeThis is a post-peer-review, pre-copyedit version of an article published in [European Journal of Epidemiology (EJE)]. The final authenticated version is available online at: https://doi.org/10.1007/s10654-018-0465-xnb_NO
cristin.unitcode194,65,20,0
cristin.unitcode194,65,15,0
cristin.unitcode1920,14,0,0
cristin.unitcode194,65,20,15
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameLaboratoriemedisinsk klinikk
cristin.unitnameHelseundersøkelsen i Nord-Trøndelag
cristin.ispublishedtrue
cristin.fulltextpreprint
cristin.fulltextpostprint
cristin.qualitycode2


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