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dc.contributor.authorBjerga, Gro Elin Kjæreng
dc.contributor.authorLale, Rahmi
dc.contributor.authorWilliamson, Adele Kim
dc.date.accessioned2019-11-18T10:58:15Z
dc.date.available2019-11-18T10:58:15Z
dc.date.created2016-01-08T10:39:27Z
dc.date.issued2016
dc.identifier.citationBioengineered. 2016, 7 (1), 33-38.nb_NO
dc.identifier.issn2165-5979
dc.identifier.urihttp://hdl.handle.net/11250/2628974
dc.description.abstractProduction of psychrophilic enzymes in the commonly used mesophilic expression systems is hampered by low intrinsic stability of the recombinant enzymes at the optimal host growth temperatures. Unless strategies for low-temperature expression are advanced, research on psychrophilic enzymes may end up being biased toward those that can be stably produced in commonly used mesophilic host systems. Two main strategies are currently being explored for the development of low-temperature expression in bacterial hosts: (i) low-temperature adaption of existing mesophilic expression systems, and (ii) development of new psychrophilic hosts. These developments include genetic engineering of the expression cassettes to optimize the promoter/operator systems that regulate heterologous expression. In this addendum we present our efforts in the development of such low-temperature expression systems, and speculate about future advancements in the field and potential applications.nb_NO
dc.language.isoengnb_NO
dc.publisherTaylor & Francisnb_NO
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titleEngineering low-temperature expression systems for heterologous production of cold-adapted enzymesnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber33-38nb_NO
dc.source.volume7nb_NO
dc.source.journalBioengineerednb_NO
dc.source.issue1nb_NO
dc.identifier.doi10.1080/21655979.2015.1128589
dc.identifier.cristin1308412
dc.description.localcode© 2016 Gro Elin Kjæreng Bjerga, Rahmi Lale, and Adele Williamson. Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been assertednb_NO
cristin.unitcode194,66,15,0
cristin.unitnameInstitutt for bioteknologi og matvitenskap
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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