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dc.contributor.authorAfset, Jan Egil
dc.contributor.authorLarssen, Kjersti Wik
dc.contributor.authorBergh, Kåre
dc.contributor.authorLärkeryd, A
dc.contributor.authorSjodin, A
dc.contributor.authorJohansson, A
dc.contributor.authorForsman, M
dc.date.accessioned2019-11-13T09:55:35Z
dc.date.available2019-11-13T09:55:35Z
dc.date.created2015-07-01T09:01:46Z
dc.date.issued2015
dc.identifier.citationEurosurveillance. 2015, 20 (19), .nb_NO
dc.identifier.issn1025-496X
dc.identifier.urihttp://hdl.handle.net/11250/2628098
dc.description.abstractIn 2011, a nationwide outbreak of tularaemia occurred in Norway with 180 recorded cases. It was associated with the largest peak in lemming density seen in 40 years. Francisella tularensis was isolated from 18 patients. To study the geographical distribution of F. tularensis genotypes in Norway and correlate genotype with epidemiology and clinical presentation, we performed whole genome sequencing of patient isolates. All 18 genomes from the outbreak carried genetic signatures of F. tularensis subsp. holarctica and were assigned to genetic clades using canonical single nucleotide polymorphisms. Ten isolates were assigned to major genetic clade B.6 (subclade B.7), seven to clade B.12, and one to clade B.4. The B.6 subclade B.7 was most common in southern and central Norway, while clade B.12 was evenly distributed between the southern, central and northern parts of the country. There was no association between genotype and clinical presentation of tularaemia, time of year or specimen type. We found extensive sequence similarity with F. tularensis subsp. holarctica genomes from high-endemic tularaemia areas in Sweden. Finding nearly identical genomes across large geographical distances in Norway and Sweden imply a life cycle of the bacterium without replication between the outbreaks and raise new questions about long-range migration mechanisms.nb_NO
dc.language.isoengnb_NO
dc.publisherEuropean Centre for Disease Prevention and Controlnb_NO
dc.titlePhylogeographical pattern of Francisella tularensis in a nationwide outbreak of tularaemia in Norway, 2011nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber6nb_NO
dc.source.volume20nb_NO
dc.source.journalEurosurveillancenb_NO
dc.source.issue19nb_NO
dc.identifier.doi10.2807/1560-7917.ES2015.20.19.21125
dc.identifier.cristin1251831
dc.description.localcodeOpen Accessnb_NO
cristin.unitcode194,65,15,0
cristin.unitcode1920,14,0,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameLaboratoriemedisinsk klinikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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