Vis enkel innførsel

dc.contributor.authorSeifi, M
dc.contributor.authorCorteen, NL
dc.contributor.authorVan der Want, Johannes
dc.contributor.authorMetzger, F
dc.contributor.authorSwinny, JD
dc.date.accessioned2019-11-08T07:40:40Z
dc.date.available2019-11-08T07:40:40Z
dc.date.created2014-11-03T15:32:59Z
dc.date.issued2014
dc.identifier.issn1662-5129
dc.identifier.urihttp://hdl.handle.net/11250/2627272
dc.description.abstractThe locus coeruleus (LC) nucleus modulates adaptive behavioral responses to stress and dysregulation of LC neuronal activity is implicated in stress-induced mental illnesses. The LC is composed primarily of noradrenergic neurons together with various glial populations. A neuroglia cell-type largely unexplored within the LC is the NG2 cell. NG2 cells serve primarily as oligodendrocyte precursor cells throughout the brain. However, some NG2 cells are in synaptic contact with neurons suggesting a role in information processing. The aim of this study was to neurochemically and anatomically characterize NG2 cells within the rat LC. Furthermore, since NG2 cells have been shown to proliferate in response to traumatic brain injury, we investigated whether such NG2 cells plasticity also occurs in response to emotive insults such as stress. Immunohistochemistry and confocal microscopy revealed that NG2 cells were enriched within the pontine region occupied by the LC. Close inspection revealed that a sub-population of NG2 cells were located within unique indentations of LC noradrenergic somata and were immunoreactive for the neuronal marker NeuN whilst NG2 cell processes formed close appositions with clusters immunoreactive for the inhibitory synaptic marker proteins gephyrin and the GABA-A receptor alpha3-subunit, on noradrenergic dendrites. In addition, LC NG2 cell processes were decorated with vesicular glutamate transporter 2 immunoreactive puncta. Finally, 10 days of repeated restraint stress significantly increased the density of NG2 cells within the LC. The study demonstrates that NG2 IR cells are integral components of the LC cellular network and they exhibit plasticity as a result of emotive challenges.nb_NO
dc.language.isoengnb_NO
dc.publisherFrontiers Medianb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleLocalization of NG2 immunoreactive neuroglia cells in the rat locus coeruleus and their plasticity in response to stressnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.volume8nb_NO
dc.source.journalFrontiers in Neuroanatomynb_NO
dc.source.issueMAYnb_NO
dc.identifier.doi10.3389/fnana.2014.00031
dc.identifier.cristin1169448
dc.description.localcodeCopyright © 2014 Seifi, Corteen, van der Want, Metzger and Swinny. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY).nb_NO
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal