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dc.contributor.authorNeupane, Sudan Prasad
dc.contributor.authorLien, Lars
dc.contributor.authorMartinez, Priscilla
dc.contributor.authorAukrust, Pål
dc.contributor.authorUeland, Thor
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorHestad, Knut
dc.contributor.authorBramness, Jørgen Gustav
dc.identifier.citationCNS Neuroscience & Therapeutics. 2014, 20 (10), 898-904.nb_NO
dc.description.abstractAs major depression (MD) is often comorbid with alcohol-use disorders (AUD) and alcohol itself modulates the immune system, we examined serum levels of interleukin (IL)-6, IL-10, tumor necrosis factor (TNF), and interferon (IFN)-γ in AUD patients with and without MD. Putative interactions between alcohol variables and MD on cytokine levels were also assessed. A consecutive sample of inpatients with AUD (N = 176) from eight alcohol treatment centers in Kathmandu, Nepal, was assessed for alcohol use and depression by administering fully structured psychiatric interviews. Serum cytokine levels were determined using multiplex technology. Alcohol-use disorders patients with a positive history of MD had higher levels of the inflammatory cytokines IL-6 (P = 0.019), TNF (P = 0.020), and IFN-γ (P = 0.001), but not of IL-10 (P = 0.853). AUD patients with MD had higher concentrations of cytokines compared with those without, regardless of the severity of the alcohol problem, but the difference was greater among those drinking in lower frequency and intensity. These findings provide evidence for altered functioning of the immune system in AUD patients with comorbid MD. However, frequent and intense drinking may attenuate the difference in the cytokine profiles between AUD patients with and without MDnb_NO
dc.description.abstractHigh frequency and intensity of drinking may attenuate increased inflammatory cytokine levels of major depression in alcohol-use disordersnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleHigh frequency and intensity of drinking may attenuate increased inflammatory cytokine levels of major depression in alcohol-use disordersnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.subject.nsiVDP::Samfunnsmedisin, sosialmedisin: 801nb_NO
dc.subject.nsiVDP::Community medicine, social medicine: 801nb_NO
dc.source.journalCNS Neuroscience & Therapeuticsnb_NO
dc.description.localcodeOpen Access CC-BYnb_NO
cristin.unitnameInstitutt for psykologi

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal