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dc.contributor.authorSun, Yi-Qian
dc.contributor.authorBrumpton, Ben Michael
dc.contributor.authorLanghammer, Arnulf
dc.contributor.authorChen, Yue
dc.contributor.authorKvaløy, Kirsti
dc.contributor.authorMai, Xiao-Mei
dc.date.accessioned2019-10-29T07:58:14Z
dc.date.available2019-10-29T07:58:14Z
dc.date.created2019-10-28T14:50:56Z
dc.date.issued2019
dc.identifier.issn0040-6376
dc.identifier.urihttp://hdl.handle.net/11250/2624994
dc.description.abstractBackground We aimed to investigate the potential causal associations of adiposity with asthma overall, asthma by atopic status or by levels of symptom control in a large adult population and stratified by sex. We also investigated the potential for reverse causation between asthma and risk of adiposity. Methods We performed a bidirectional one-sample Mendelian randomisation (MR) study using the Norwegian Nord-Trøndelag Health Study population including 56 105 adults. 73 and 47 genetic variants were included as instrumental variables for body mass index (BMI) and waist-to-hip ratio (WHR), respectively. Asthma was defined as ever asthma, doctor-diagnosed asthma and doctor-diagnosed active asthma, and was further classified by atopic status or levels of symptom control. Causal OR was calculated with the Wald method. Results The ORs per 1 SD (4.1 kg/m2) increase in genetically determined BMI were ranged from 1.36 to 1.49 for the three asthma definitions and similar for women and men. The corresponding ORs for non-atopic asthma (range 1.42–1.72) appeared stronger than those for the atopic asthma (range 1.18–1.26), but they were similar for controlled versus partly controlled doctor-diagnosed active asthma (1.43 vs 1.44). There was no clear association between genetically predicted WHR and asthma risk or between genetically predicted asthma and the adiposity markers. Conclusions Our MR study provided evidence of a causal association of BMI with asthma in adults, particularly with non-atopic asthma. There was no clear evidence of a causal link between WHR and asthma or of reverse causation.nb_NO
dc.language.isoengnb_NO
dc.publisherBMJ Publishing Groupnb_NO
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titleAdiposity and asthma in adults: a bidirectional Mendelian randomization analysis of the HUNT Studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.journalThoraxnb_NO
dc.identifier.doi10.1136/thoraxjnl-2019-213678
dc.identifier.cristin1741275
dc.description.localcodeThis article has been accepted for publication following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/thoraxjnl-2019-213678 © Authors 2019. Reuse of this manuscript version (excluding any databases, tables, diagrams, photographs and other images or illustrative material included where a another copyright owner is identified) is permitted strictly pursuant to the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC-BY-NC 4.0) http://creativecommons.orgnb_NO
cristin.unitcode194,65,15,0
cristin.unitcode194,65,20,0
cristin.unitcode194,65,20,15
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.unitnameHelseundersøkelsen i Nord-Trøndelag
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2


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Navngivelse-Ikkekommersiell 4.0 Internasjonal
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