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dc.contributor.authorHaugland, Kamilla Gjerland
dc.contributor.authorSugar, Jørgen
dc.contributor.authorWitter, Menno
dc.identifier.citationEuropean Journal of Neuroscience. 2019, 1-21.nb_NO
dc.description.abstractThe rat hippocampal formation (HF), parahippocampal region (PHR), and retrosplenial cortex (RSC) play critical roles in spatial processing. These regions are interconnected, and functionally dependent. The neuronal networks mediating this reciprocal dependency are largely unknown. Establishing the developmental timing of network formation will help to understand the emergence of this dependency. We questioned whether the long‐range outputs from HF‐PHR to RSC in Long Evans rats develop during the same time periods as previously reported for the intrinsic HF‐PHR connectivity and the projections from RSC to HF‐PHR. The results of a series of retrograde and anterograde tracing experiments in rats of different postnatal ages show that the postnatal projections from HF‐PHR to RSC display low densities around birth, but develop during the first postnatal week, reaching adult‐like densities around the time of eye‐opening. Developing projections display a topographical organization similar to adult projections. We conclude that the long‐range projections from HF‐PHR to RSC develop in parallel with the intrinsic circuitry of HF‐PHR and the projections of RSC to HF‐PHR.nb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleDevelopment and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortexnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalEuropean Journal of Neurosciencenb_NO
dc.relation.projectNorges forskningsråd: Centre for Neural Computation 223262nb_NO
dc.relation.projectNorges forskningsråd: NORBRAIN 1 197467nb_NO
dc.relation.projectUniversitetet i Tromsø: The Arctic University of Norway 227769nb_NO
dc.description.localcode© 2019 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution Licensenb_NO
cristin.unitnameKavliinstitutt for nevrovitenskap

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Navngivelse 4.0 Internasjonal
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