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dc.contributor.authorXie, Minli
dc.contributor.authorMagnus Østgård, Olderøy
dc.contributor.authorZhang, Zhibing
dc.contributor.authorAndreassen, Jens-Petter
dc.contributor.authorStrand, Berit Løkensgard
dc.contributor.authorSikorski, Pawel
dc.date.accessioned2019-10-11T08:31:36Z
dc.date.available2019-10-11T08:31:36Z
dc.date.created2012-02-16T08:47:35Z
dc.date.issued2012
dc.identifier.citationRSC Advances. 2012, 2 (4), 1457-1465.nb_NO
dc.identifier.issn2046-2069
dc.identifier.urihttp://hdl.handle.net/11250/2621504
dc.description.abstractThis study set out to develop a biomimetic scaffold by incorporating osteoinductive hydroxyapatite (HA) particles into a porous alginate gel matrix via a cell-friendly pathway. Two types of alginate/calcium phosphate (Alg/CP) composites were prepared through alkaline phosphatase (ALP) mediated mineralization and counter-diffusion precipitation. Structural characteristics were analyzed by scanning electron microscopy (SEM) and scanning transmission electron microscopy (STEM). Thermal stability and mineral content were studied by means of thermogravimetric (TG) analysis. X-ray diffraction (XRD) and Rietveld refinement showed the presence of bone-like hydroxyapatite. Our studies suggested that the gradual nature of enzymatic process together with alginate matrices provide regulation of nanocrystalline hydroxyapatite formation. The ALP-mediated mineralization process has great advantages over counter-diffusion precipitation, providing homogenous mineral distributions, smaller crystal sizes, and increased apparent Young's moduli, which creates a better structure for bone defect repair scaffolds.nb_NO
dc.language.isoengnb_NO
dc.publisherRoyal Society of Chemistrynb_NO
dc.titleBiocomposites prepared by alkaline phosphatase mediated mineralization of alginate microbeadsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber1457-1465nb_NO
dc.source.volume2nb_NO
dc.source.journalRSC Advancesnb_NO
dc.source.issue4nb_NO
dc.identifier.doi10.1039/c1ra00750e
dc.identifier.cristin909877
dc.description.localcodeOpen Accessnb_NO
cristin.unitcode194,66,20,0
cristin.unitcode194,66,30,0
cristin.unitcode194,66,15,0
cristin.unitnameInstitutt for fysikk
cristin.unitnameInstitutt for kjemisk prosessteknologi
cristin.unitnameInstitutt for bioteknologi og matvitenskap
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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