dc.contributor.author | Xie, Minli | |
dc.contributor.author | Magnus Østgård, Olderøy | |
dc.contributor.author | Zhang, Zhibing | |
dc.contributor.author | Andreassen, Jens-Petter | |
dc.contributor.author | Strand, Berit Løkensgard | |
dc.contributor.author | Sikorski, Pawel | |
dc.date.accessioned | 2019-10-11T08:31:36Z | |
dc.date.available | 2019-10-11T08:31:36Z | |
dc.date.created | 2012-02-16T08:47:35Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | RSC Advances. 2012, 2 (4), 1457-1465. | nb_NO |
dc.identifier.issn | 2046-2069 | |
dc.identifier.uri | http://hdl.handle.net/11250/2621504 | |
dc.description.abstract | This study set out to develop a biomimetic scaffold by incorporating osteoinductive hydroxyapatite (HA) particles into a porous alginate gel matrix via a cell-friendly pathway. Two types of alginate/calcium phosphate (Alg/CP) composites were prepared through alkaline phosphatase (ALP) mediated mineralization and counter-diffusion precipitation. Structural characteristics were analyzed by scanning electron microscopy (SEM) and scanning transmission electron microscopy (STEM). Thermal stability and mineral content were studied by means of thermogravimetric (TG) analysis. X-ray diffraction (XRD) and Rietveld refinement showed the presence of bone-like hydroxyapatite. Our studies suggested that the gradual nature of enzymatic process together with alginate matrices provide regulation of nanocrystalline hydroxyapatite formation. The ALP-mediated mineralization process has great advantages over counter-diffusion precipitation, providing homogenous mineral distributions, smaller crystal sizes, and increased apparent Young's moduli, which creates a better structure for bone defect repair scaffolds. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Royal Society of Chemistry | nb_NO |
dc.title | Biocomposites prepared by alkaline phosphatase mediated mineralization of alginate microbeads | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1457-1465 | nb_NO |
dc.source.volume | 2 | nb_NO |
dc.source.journal | RSC Advances | nb_NO |
dc.source.issue | 4 | nb_NO |
dc.identifier.doi | 10.1039/c1ra00750e | |
dc.identifier.cristin | 909877 | |
dc.description.localcode | Open Access | nb_NO |
cristin.unitcode | 194,66,20,0 | |
cristin.unitcode | 194,66,30,0 | |
cristin.unitcode | 194,66,15,0 | |
cristin.unitname | Institutt for fysikk | |
cristin.unitname | Institutt for kjemisk prosessteknologi | |
cristin.unitname | Institutt for bioteknologi og matvitenskap | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |