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dc.contributor.authorStunes, Astrid Kamilla
dc.contributor.authorWestbroek, Irene
dc.contributor.authorFossmark, Reidar
dc.contributor.authorBerge, Rolf Kristian
dc.contributor.authorReseland, Janne Elin
dc.contributor.authorSyversen, Unni
dc.date.accessioned2019-10-11T06:24:25Z
dc.date.available2019-10-11T06:24:25Z
dc.date.created2012-01-03T15:05:22Z
dc.date.issued2011
dc.identifier.citationPPAR Research. 2011, 2011 .nb_NO
dc.identifier.issn1687-4757
dc.identifier.urihttp://hdl.handle.net/11250/2621485
dc.description.abstractThis study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), were given TTA or vehicle daily for 4 months. Bone markers in plasma, whole body and femoral bone mineral density and content (BMD and BMC), and body composition were examined. Histomorphometric and biomechanical analyses (Study I) and biomechanical and μCT analyses (Study II) of the femur were performed. Normal rats fed TTA had higher femoral BMD and increased total and cortical area in femur compared to controls. The ovariectomized groups had decreased BMD and impaired microarchitecture parameters compared to SHAM. However, the TTA OVX group maintained femoral BMC, trabecular thickness in the femoral head, and cortical volume in the femoral metaphysis as SHAM. TTA might increase BMD and exert a light preventive effect on estrogen-related bone loss in rats.nb_NO
dc.language.isoengnb_NO
dc.publisherHindawinb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleSkeletal effects of the saturated 3-thia fatty acid tetradecylthioacetic acid in ratsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber10nb_NO
dc.source.volume2011nb_NO
dc.source.journalPPAR Researchnb_NO
dc.identifier.doi10.1155/2011/436358
dc.identifier.cristin875780
dc.description.localcodeCopyright © 2011 Astrid Kamilla Stunes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.nb_NO
cristin.unitcode194,65,15,0
cristin.unitcode1920,15,0,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameMedisinsk klinikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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