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dc.contributor.authorLarsen, Eivind La Puebla
dc.contributor.authorRandeberg, Lise Lyngsnes
dc.contributor.authorOlstad, Elisabeth
dc.contributor.authorHaugen, Olav Anton
dc.contributor.authorAksnes, Astrid
dc.contributor.authorSvaasand, Lars O.
dc.date.accessioned2019-10-10T11:06:39Z
dc.date.available2019-10-10T11:06:39Z
dc.date.created2011-09-13T16:09:20Z
dc.date.issued2011
dc.identifier.citationJournal of Biomedical Optics. 2011, 16 (2), .nb_NO
dc.identifier.issn1083-3668
dc.identifier.urihttp://hdl.handle.net/11250/2621377
dc.description.abstractVulnerable plaques constitute a risk for serious heart problems, and are difficult to identify using existing methods. Hyperspectral imaging combines spectral- and spatial information, providing new possibilities for precise optical characterization of atherosclerotic lesions. Hyperspectral data were collected from excised aorta samples (n = 11) using both white-light and ultraviolet illumination. Single lesions (n = 42) were chosen for further investigation, and classified according to histological findings. The corresponding hyperspectral images were characterized using statistical image analysis tools (minimum noise fraction, K-means clustering, principal component analysis) and evaluation of reflectance/fluorescence spectra. Image analysis combined with histology revealed the complexity and heterogeneity of aortic plaques. Plaque features such as lipids and calcifications could be identified from the hyperspectral images. Most of the advanced lesions had a central region surrounded by an outer rim or shoulder-region of the plaque, which is considered a weak spot in vulnerable lesions. These features could be identified in both the white-light and fluorescence data. Hyperspectral imaging was shown to be a promising tool for detection and characterization of advanced atherosclerotic plaques in vitro. Hyperspectral imaging provides more diagnostic information about the heterogeneity of the lesions than conventional single point spectroscopic measurements.nb_NO
dc.language.isoengnb_NO
dc.publisherSociety of Photo-optical Instrumentation Engineers (SPIE)nb_NO
dc.titleHyperspectral imaging of atherosclerotic plaques in vitronb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber11nb_NO
dc.source.volume16nb_NO
dc.source.journalJournal of Biomedical Opticsnb_NO
dc.source.issue2nb_NO
dc.identifier.doi10.1117/1.3540657
dc.identifier.cristin839048
dc.description.localcode© (2011) Society of Photo-Optical Instrumentation Engineers (SPIE)nb_NO
cristin.unitcode194,63,35,0
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for elektroniske systemer
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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