dc.contributor.author | Grent-’t-Jong, Tineke | |
dc.contributor.author | Gross, Joachim | |
dc.contributor.author | Goense, Jozien | |
dc.contributor.author | Wibral, Michael | |
dc.contributor.author | Gajwani, Ruchika | |
dc.contributor.author | Gumley, Andrew I. | |
dc.contributor.author | Lawrie, Stephen M. | |
dc.contributor.author | Schwannauer, Matthias | |
dc.contributor.author | Schultze-Lutter, Frauke | |
dc.contributor.author | Navarro Schröder, Tobias | |
dc.contributor.author | Koethe, Dagmar | |
dc.contributor.author | Leweke, Markus | |
dc.contributor.author | Singer, Wolf | |
dc.contributor.author | Uhlhaas, Peter J. | |
dc.date.accessioned | 2019-09-19T08:26:46Z | |
dc.date.available | 2019-09-19T08:26:46Z | |
dc.date.created | 2019-01-18T11:33:08Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | eLIFE. 2018, 7 1-19. | nb_NO |
dc.identifier.issn | 2050-084X | |
dc.identifier.uri | http://hdl.handle.net/11250/2617593 | |
dc.description.abstract | We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were obtained in CHR-participants and matched controls. Magnetoencephalographic (MEG) resting-state activity was examined at source level and MEG-data were correlated with neuropsychological scores and clinical symptoms. CHR-participants were characterized by increased 64–90 Hz power. In contrast, FEP- and ScZ-patients showed aberrant spectral power at both low- and high gamma-band frequencies. MRS-data showed a shift in E/I-balance toward increased excitation in CHR-participants, which correlated with increased occipital gamma-band power. Finally, neuropsychological deficits and clinical symptoms in FEP and ScZ-patients were correlated with reduced gamma band-activity, while elevated psychotic symptoms in the CHR group showed the opposite relationship. The current study suggests that resting-state gamma-band power and altered Glx/GABA ratio indicate changes in E/I-balance parameters across illness stages in ScZ. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | eLife Sciences Publications | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1-19 | nb_NO |
dc.source.volume | 7 | nb_NO |
dc.source.journal | eLIFE | nb_NO |
dc.identifier.doi | 10.7554/eLife.37799 | |
dc.identifier.cristin | 1660076 | |
dc.description.localcode | Copyright Grent-’t-Jong et al. This article is distributed under the terms of the Creative Commons Attribution License | nb_NO |
cristin.unitcode | 194,65,60,0 | |
cristin.unitname | Kavliinstitutt for nevrovitenskap | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |