dc.contributor.author | Bukhari, Syed Majid | |
dc.contributor.author | Feuerherm, Astrid Jullumstrø | |
dc.contributor.author | Tunset, Hanna Maja | |
dc.contributor.author | Isaksen, Stian Moe | |
dc.contributor.author | Sæther, Mari | |
dc.contributor.author | Thvedt, Thor Håkon Krane | |
dc.contributor.author | Villa Gonzalez, Susana | |
dc.contributor.author | Schmid, Rudolf | |
dc.contributor.author | Brunsvik, Anders | |
dc.contributor.author | Fuglseth, Erik | |
dc.contributor.author | Zlatković, Bojan | |
dc.contributor.author | Johansen, Berit | |
dc.contributor.author | Simic, Nebojsa | |
dc.date.accessioned | 2019-09-18T14:14:57Z | |
dc.date.available | 2019-09-18T14:14:57Z | |
dc.date.created | 2014-05-13T13:22:16Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Journal of the Serbian Chemical Society. 2016, 81 (1), 1-12. | nb_NO |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | http://hdl.handle.net/11250/2617495 | |
dc.description.abstract | The activation of phospholipase A2 (PLA2) by means of pro-inflammatory cytokines results in the subsequent release of arachidonic acid (AA) and generates eicosanoids, which further propagate inflammation. Through cyclooxygenases (COX1/2) responsible for the enzymatic conversion of AA to eicosanoids, non-steroidal anti-inflammatory drugs are effective in relieving the pain and discomfort of inflammation. Using the AA release assay as a guide for biological and anti-inflammatory activity, the novel compound 1-O- -(3-O-linolenoyl-6-deoxy-6-sulfo-α-D-glucopyranosyl)glycerol (1) together with five known compounds, i.e., isovitexin, byzantionoside B, tricin 4′-O- -(erythro-β-guaiacylglyceryl) ether 7-O-β-glucopyranoside, 1-O-feruloylglycerol and tricin 7-glucoside, isolated from the methanol extract of the aerial parts of Sclerochloa dura using LC techniques (Sephadex LH-20 column chromatography, preparative HPLC and semi-preparative HPLC), were evaluated. All the isolated compounds were identified using spectroscopic methods, i.e., NMR spectroscopy and MS spectrometry. The novel compound 1 was found to be an effective inhibitor of AA release with an IC50 value of 0.09±0.03 mg mL-1. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Serbian Chemical Society | nb_NO |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | A novel compound isolated from Sclerochloa dura has anti-inflammatory effects | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1-12 | nb_NO |
dc.source.volume | 81 | nb_NO |
dc.source.journal | Journal of the Serbian Chemical Society | nb_NO |
dc.source.issue | 1 | nb_NO |
dc.identifier.doi | 10.2298/JSC150119055B | |
dc.identifier.cristin | 1132527 | |
dc.description.localcode | licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (CC BY NC ND) | nb_NO |
cristin.unitcode | 194,66,25,0 | |
cristin.unitcode | 194,66,10,0 | |
cristin.unitcode | 194,17,0,0 | |
cristin.unitname | Institutt for kjemi | |
cristin.unitname | Institutt for biologi | |
cristin.unitname | Prorektor for nyskaping | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |