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dc.contributor.authorAmin, Faisal Mohammad
dc.contributor.authorAristeidou, Stavroula
dc.contributor.authorBaraldi, Carlo
dc.contributor.authorCzapinska-Ciepiela, Ewa K.
dc.contributor.authorAriadni, Daponte D.
dc.contributor.authorDi Lenola, Davide
dc.contributor.authorFenech, Cherilyn
dc.contributor.authorKampouris, Konstantinos
dc.contributor.authorKaragiorgis, Giorgos
dc.contributor.authorBraschinsky, Mark
dc.contributor.authorLinde, Mattias
dc.identifier.citationThe Journal of Headache and Pain. 2018, 19 1-9.nb_NO
dc.description.abstractBackground There is an unmet need of pharmacological and non-pharmacological treatment options for migraine patients. Exercise can be used in the treatment of several pain conditions, including. However, what exact role exercise plays in migraine prevention is unclear. Here, we review the associations between physical exercise and migraine from an epidemiological, therapeutical and pathophysiological perspective. Methods The review was based on a primary literature search on the PubMed using the search terms “migraine and exercise”. Results Low levels of physical exercise and high frequency of migraine has been reported in several large population-based studies. In experimental studies exercise has been reported as a trigger factor for migraine as well as migraine prophylaxis. Possible mechanisms for how exercise may trigger migraine attacks, include acute release of neuropeptides such as calcitonin gene-related peptide or alternation of hypocretin or lactate metabolism. Mechanisms for migraine prevention by exercise may include increased beta-endorphin, endocannabinoid and brain-derived neurotrophic factor levers in plasma after exercise. Conclusion In conclusion, it seems that although exercise can trigger migraine attacks, regular exercise may have prophylactic effect on migraine frequency. This is most likely due to an altered migraine triggering threshold in persons who exercise regularly. However, the frequency and intensity of exercise that is required is still an open question, which should be addressed in future studies to delineate an evidence-based exercise program to prevent migraine in sufferers.nb_NO
dc.publisherBioMed Centralnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleThe association between migraine and physical exercisenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalThe Journal of Headache and Painnb_NO
dc.description.localcodeOpen Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.nb_NO
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap
cristin.unitnameNasjonal kompetansetjeneste for hodepine

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal