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dc.contributor.authorWaldum, Helge
dc.contributor.authorÖberg, Kjell
dc.contributor.authorSørdal, Øystein Finset
dc.contributor.authorSandvik, Arne Kristian
dc.contributor.authorGustafsson, Björn
dc.contributor.authorMjønes, Patricia
dc.contributor.authorFossmark, Reidar
dc.identifier.citationTherapeutic Advances in Gastroenterology. 2018, 11 1-17.nb_NO
dc.description.abstractStem cells are considered the origin of neoplasms in general, and malignant tumours in particular, and the stage at which the stem cells stop their differentiation determines the degree of malignancy. However, there is increasing evidence supporting an alternative paradigm. Tumours may develop by dedifferentiation from mature cells able to proliferate. Studies of gastric carcinogenesis demonstrate that mature neuroendocrine (NE) cells upon long-term overstimulation may develop through stages of hyperplasia, dysplasia, and rather benign tumours, into highly malignant carcinomas. Dedifferentiation of cells may change the histological appearance and impede the identification of the cellular origin, as seen with gastric carcinomas, which in many cases are dedifferentiated neuroendocrine tumours. Finding the cell of origin is important to identify risk factors for cancer, prevent tumour development, and tailor treatment. In the present review, we focus not only on gastric tumours, but also evaluate the role of neuroendocrine cells in tumourigenesis in two other foregut-derived organs, the lungs and the pancreas, as well as in the midgut-derived small intestine.nb_NO
dc.publisherSage Publicationsnb_NO
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titleNot only stem cells, but also mature cells, particularly neuroendocrine cells, may develop into tumours: time for a paradigm shiftnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalTherapeutic Advances in Gastroenterologynb_NO
dc.description.localcodeThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameMedisinsk klinikk
cristin.unitnameLaboratoriemedisinsk klinikk

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
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