dc.contributor.author | Gulati, Agnete Malm | |
dc.contributor.author | Salvesen, Øyvind | |
dc.contributor.author | Thomsen, Ruth Stoklund | |
dc.contributor.author | Kavanaugh, Arthur | |
dc.contributor.author | Semb, Anne Grete | |
dc.contributor.author | Rollefstad, Silvia Christin Hellerud | |
dc.contributor.author | Haugeberg, Glenn | |
dc.contributor.author | Hoff, Mari | |
dc.date.accessioned | 2019-08-30T08:41:07Z | |
dc.date.available | 2019-08-30T08:41:07Z | |
dc.date.created | 2018-09-26T13:37:18Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | RMD Open. 2018, 4 (1), 1-6. | nb_NO |
dc.identifier.issn | 2056-5933 | |
dc.identifier.uri | http://hdl.handle.net/11250/2611773 | |
dc.description.abstract | Objectives
The aim of this population-based study was to compare changes in cardiovascular (CV) risk factors over a decade-long period in patients who developed psoriatic arthritis (PsA) and the background population.
Methods
Patients diagnosed with PsA (n=151) between 1998 and 2008 and matched controls (n=755) who participated in both the Nord-Trøndelag Health Study (HUNT) 2 (1995–1997) and HUNT3 (2006–2008) were included. Mixed linear and logistic models were used to analyse the difference in mean change between HUNT2 and HUNT3 in patients and controls for body mass index (BMI), total cholesterol (TC), triglycerides, low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c) and blood pressure (BP).
Results
At baseline (HUNT2), the patients who developed PsA compared with controls had higher BMI (27.2 vs 25.9 kg/m2, p<0.001) and lower HDL-c (1.32 vs 1.40 mmol/L, p<0.03) and more were smokers (41.1 vs 28.5%, p<0.01). Seventy-eight per cent had skin psoriasis. The mean PsA disease duration at HUNT3 was 4.8 (+/–3.0) years. The patients who developed PsA gained less weight from HUNT2 to HUNT3 compared with the control group (2.1 vs 3.9 kg, difference in mean change −1.8 kg, 95% CI −3.9 to −0.5, p<0.01). TC, triglycerides, LDL-c or HDL-c values and BP declined in both groups, with no significant differences between groups. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | BMJ Publishing Group | nb_NO |
dc.rights | Navngivelse-Ikkekommersiell 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/deed.no | * |
dc.subject | Kardiovaskulær medisin | nb_NO |
dc.subject | Cardiovascular medicine | nb_NO |
dc.title | Change in cardiovascular risk factors in patients who develop psoriatic arthritis: longitudinal data from the Nord-Trøndelag Health Study (HUNT) | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.subject.nsi | VDP::Reumatologi: 759 | nb_NO |
dc.subject.nsi | VDP::Rheumatology: 759 | nb_NO |
dc.source.pagenumber | 1-6 | nb_NO |
dc.source.volume | 4 | nb_NO |
dc.source.journal | RMD Open | nb_NO |
dc.source.issue | 1 | nb_NO |
dc.identifier.doi | 10.1136/rmdopen-2017-000630 | |
dc.identifier.cristin | 1614045 | |
dc.description.localcode | © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ | nb_NO |
cristin.unitcode | 1920,9,0,0 | |
cristin.unitcode | 194,65,30,0 | |
cristin.unitcode | 194,65,1,0 | |
cristin.unitcode | 194,65,20,0 | |
cristin.unitname | Klinikk for ortopedi, revmatologi og hudsykdommer | |
cristin.unitname | Institutt for nevromedisin og bevegelsesvitenskap | |
cristin.unitname | MH fakultetsadministrasjon | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |