dc.contributor.author | Ueland, Thor | |
dc.contributor.author | Kleveland, Ola | |
dc.contributor.author | Michelsen, Annika | |
dc.contributor.author | Wiseth, Rune | |
dc.contributor.author | Damås, Jan Kristian | |
dc.contributor.author | Holven, Kirsten Bjørklund | |
dc.contributor.author | Aukrust, Pål | |
dc.contributor.author | Gullestad, Lars | |
dc.contributor.author | Yndestad, Arne | |
dc.contributor.author | Halvorsen, Bente | |
dc.date.accessioned | 2019-07-08T11:54:44Z | |
dc.date.available | 2019-07-08T11:54:44Z | |
dc.date.created | 2018-08-03T15:02:13Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | International Journal of Cardiology. 2018, . | nb_NO |
dc.identifier.issn | 0167-5273 | |
dc.identifier.uri | http://hdl.handle.net/11250/2603744 | |
dc.description.abstract | Background
The IL-6 receptor antagonist tocilizumab has been shown to attenuate the proatherogenic lipoprotein a [Lp(a)] in rheumatoid arthritis. We evaluated if a single dose of tocilizumab reduced Lp(a) in patients with non-ST-elevation myocardial infarction (NSTEMI).
Methods
Lp(a) was assessed by immunoassay (n = 117 patients) at 7 consecutive time-points between day 1 and 3 and at 3 and 6 months follow-up.
Results
Tocilizumab did not affect Lp(a) at any time-point during the study and was not associated with cardiovascular risk factors.
Conclusions
Short-time inhibition of IL-6 with tocilizumab in patients with NSTEMI did not influence Lp(a) levels. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Elsevier | nb_NO |
dc.title | Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 3 | nb_NO |
dc.source.journal | International Journal of Cardiology | nb_NO |
dc.identifier.doi | 10.1016/j.ijcard.2018.06.093 | |
dc.identifier.cristin | 1599678 | |
dc.description.localcode | This article will not be available due to copyright restrictions (c) 2018 by Elsevier | nb_NO |
cristin.unitcode | 194,65,25,0 | |
cristin.unitcode | 194,65,15,0 | |
cristin.unitname | Institutt for sirkulasjon og bildediagnostikk | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |