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dc.contributor.authorUeland, Thor
dc.contributor.authorKleveland, Ola
dc.contributor.authorMichelsen, Annika
dc.contributor.authorWiseth, Rune
dc.contributor.authorDamås, Jan Kristian
dc.contributor.authorHolven, Kirsten Bjørklund
dc.contributor.authorAukrust, Pål
dc.contributor.authorGullestad, Lars
dc.contributor.authorYndestad, Arne
dc.contributor.authorHalvorsen, Bente
dc.date.accessioned2019-07-08T11:54:44Z
dc.date.available2019-07-08T11:54:44Z
dc.date.created2018-08-03T15:02:13Z
dc.date.issued2018
dc.identifier.citationInternational Journal of Cardiology. 2018, .nb_NO
dc.identifier.issn0167-5273
dc.identifier.urihttp://hdl.handle.net/11250/2603744
dc.description.abstractBackground The IL-6 receptor antagonist tocilizumab has been shown to attenuate the proatherogenic lipoprotein a [Lp(a)] in rheumatoid arthritis. We evaluated if a single dose of tocilizumab reduced Lp(a) in patients with non-ST-elevation myocardial infarction (NSTEMI). Methods Lp(a) was assessed by immunoassay (n = 117 patients) at 7 consecutive time-points between day 1 and 3 and at 3 and 6 months follow-up. Results Tocilizumab did not affect Lp(a) at any time-point during the study and was not associated with cardiovascular risk factors. Conclusions Short-time inhibition of IL-6 with tocilizumab in patients with NSTEMI did not influence Lp(a) levels.nb_NO
dc.language.isoengnb_NO
dc.publisherElseviernb_NO
dc.titleSerum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarctionnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber3nb_NO
dc.source.journalInternational Journal of Cardiologynb_NO
dc.identifier.doi10.1016/j.ijcard.2018.06.093
dc.identifier.cristin1599678
dc.description.localcodeThis article will not be available due to copyright restrictions (c) 2018 by Elseviernb_NO
cristin.unitcode194,65,25,0
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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