Blar i St. Olavs hospital på forfatter "Yurchenko, Mariya"
-
Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivo
Nilsen, Kaja Elisabeth; Zhang, Boyao; Skjesol, Astrid; Ryan, Liv; Vagle, Hilde; Bøe, Maren Helene; Orning, Pontus; Kim, Hera; Bakke, Siril Skaret; Elamurugan, Kirusika; Mestvedt, Ingvild Bergdal; Stenvik, Jørgen; Husebye, Harald; Lien, Egil; Espevik, Terje; Yurchenko, Mariya (Peer reviewed; Journal article, 2023)Inflammation plays a crucial role in the development and progression of many diseases, and is often caused by dysregulation of signalling from pattern recognition receptors, such as TLRs. Inhibition of key protein–protein ... -
The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes
Kastnes, Martin Haugrud; Aass, Kristin Roseth; Bouma, Siri Anshushaug; Årseth, Charlotte; Zahoor, Muhammad; Yurchenko, Mariya; Standal, Therese (Peer reviewed; Journal article, 2023)IL-32 is a pro-inflammatory cytokine expressed by several types of cancer cells and immune cells. Currently, no treatment targeting IL-32 is available, and its intracellular and exosomal localization make IL-32 less ... -
The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2
Skjesol, Astrid; Yurchenko, Mariya; Bösl, Korbinian; Gravastrand, Caroline S.; Nilsen, Kaja Elisabeth; Grøvdal, Lene Melsæther; Agliano, Federica; Patane, Francesco; Lentini, Germana; Kim, Hera; Teti, Giuseppe; Sharma, Aditya Kumar; Kandasamy, Richard Kumaran; Sporsheim, Bjørnar; Starheim, Kristian K.; Golenbock, Douglas T.; Stenmark, Harald; McCaffrey, Mary; Espevik, Terje; Husebye, Harald (Journal article; Peer reviewed, 2019)Phagocytosis is a complex process that eliminates microbes and is performed by specialised cells such as macrophages. Toll-like receptor 4 (TLR4) is expressed on the surface of macrophages and recognizes Gram-negative ... -
TIRAP/Mal Positively Regulates TLR8‐Mediated Signaling via IRF5 in Human Cells
Nilsen, Kaja Elisabeth; Skjesol, Astrid; Kojen, June Frengen; Espevik, Terje; Stenvik, Jørgen; Yurchenko, Mariya (Peer reviewed; Journal article, 2022)Toll-like receptor 8 (TLR8) recognizes single-stranded RNA of viral and bacterial origin as well as mediates the secretion of pro-inflammatory cytokines and type I interferons by human monocytes and macrophages. TLR8, as ... -
The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2
Skjesol, Astrid; Yurchenko, Mariya; Bösl, Korbinian; Gravastrand, Caroline S.; Nilsen, Kaja Elisabeth; Grøvdal, Lene Melsæther; Agliano, Federica; Patane, Francesco; Lentini, Germana; Kim, Hera; Teti, Giuseppe; Sharma, Aditya Kumar; Kandasamy, Richard Kumaran; Sporsheim, Bjørnar; Starheim, Kristian K.; Golenbock, Douglas T.; Stenmark, Harald; McCaffrey, Mary; Espevik, Terje; Husebye, Harald (Peer reviewed; Journal article, 2019)Phagocytosis is a complex process that eliminates microbes and is performed by specialised cells such as macrophages. Toll-like receptor 4 (TLR4) is expressed on the surface of macrophages and recognizes Gram-negative ...