Blar i St. Olavs hospital på forfatter "Sandvik, Arne Kristian"
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Comprehensive protocols for culturing and molecular biological analysis of IBD patient-derived colon epithelial organoids
Gopalakrishnan, Shreya; Bakke, Ingunn; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Granlund, Atle van Beelen; Sandvik, Arne Kristian; Bruland, Torunn (Journal article; Peer reviewed, 2023) -
Deep learning-based image analysis reveals significant differences in the number and distribution of mucosal CD3 and γδ T cells between Crohn's disease and ulcerative colitis
Røyset, Elin Synnøve; Pettersen, Henrik Sahlin; Xu, Weili; Larbi, Anis; Sandvik, Arne Kristian; Steigen, Sonja Eriksson; Catalan-Serra, Ignacio; Bakke, Ingunn (Peer reviewed; Journal article, 2022)Colon mucosae of ulcerative colitis (UC) and Crohn's disease (CD) display differences in the number and distribution of immune cells that are difficult to assess by eye. Deep learning-based analysis on whole slide images ... -
Host-Viral Interactions in the Pathogenesis of Ulcerative Colitis
Bruland, Torunn; Østvik, Ann Elisabet; Sandvik, Arne Kristian; Hansen, Marianne Dore (Peer reviewed; Journal article, 2021)Ulcerative colitis is characterized by relapsing and remitting colonic mucosal inflammation. During the early stages of viral infection, innate immune defenses are activated, leading to the rapid release of cytokines and ... -
The ileal fungal microbiota is altered in Crohn's disease and is associated with the disease course
Olaisen, Maya; Richard, Mathias L.; Beisvag, Vidar; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Rué, Olivier; Martinsen, Tom Christian; Sandvik, Arne Kristian; Sokol, Harry; Fossmark, Reidar (Peer reviewed; Journal article, 2022)Introduction: Fungal microbiota's involvement in the pathogenesis of Crohn's disease (CD) is incompletely understood. The terminal ileum is a predilection site both for primary involvement and recurrences of CD. We, ... -
Intestinal epithelial cells express immunomodulatory ISG15 during active ulcerative colitis and Crohn's disease
Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Skovdahl, Helene Kolstad; Bakke, Ingunn; Thorsvik, Silje; Afroz, Wahida; Walaas, Gunnar Andreas; Mollnes, Tom Eirik; Gustafsson, Björn; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2020)Background and Aims Intestinal epithelial cells [IECs] secrete cytokines that recruit immune cells to the mucosa and regulate immune responses that drive inflammation in inflammatory bowel disease [IBD]. However, experiments ... -
Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis
Olaisen, Maya; Spigset, Olav; Flatberg, Arnar; Granlund, Atle van Beelen; Brede, wenche Rødseth; Albrektsen, Grethe; Røyset, Elin Synnøve; Gilde, Bodil; Sandvik, Arne Kristian; Martinsen, Tom Christian; Fossmark, Reidar (Journal article; Peer reviewed, 2019)Background 5‐aminosalicylic acid (5‐ASA) is the first‐line therapy for ulcerative colitis (UC). 5‐ASA acts locally in the colonic mucosa by numerous proposed mechanisms, and is metabolised by N‐acetyltransferase (NAT). ... -
Mucosal and faecal neutrophil gelatinase-associated lipocalin as potential biomarkers for collagenous colitis
Bakke, Ingunn; Walaas, Gunnar Andreas; Bruland, Torunn; Røyset, Elin Synnøve; Granlund, Atle van Beelen; Escudero-Hernandez, Celia; Thorsvik, Silje; Münch, Andreas; Sandvik, Arne Kristian; Østvik, Ann Elisabet (Peer reviewed; Journal article, 2021)Background Collagenous colitis (CC) is an inflammatory bowel disease where chronic diarrhoea is the main symptom. Diagnostic markers distinguishing between CC and other causes of chronic diarrhoea remain elusive. This study ... -
Not only stem cells, but also mature cells, particularly neuroendocrine cells, may develop into tumours: time for a paradigm shift
Waldum, Helge; Öberg, Kjell; Sørdal, Øystein Finset; Sandvik, Arne Kristian; Gustafsson, Björn; Mjønes, Patricia; Fossmark, Reidar (Journal article; Peer reviewed, 2018)Stem cells are considered the origin of neoplasms in general, and malignant tumours in particular, and the stage at which the stem cells stop their differentiation determines the degree of malignancy. However, there is ... -
Patient derived colonoids as drug testing platforms-Critical importance of oxygen concentration
Skovdahl, Helene Kolstad; Gopalakrishnan, Shreya; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Bakke, Ingunn; Ginbot, Zekarias; Thorsvik, Silje; Flatberg, Arnar; Sporsheim, Bjørnar; Ostrop, Jenny; Mollnes, Tom Eirik; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2021)Treatment of inflammatory bowel disease (IBD) is challenging, with a series of available drugs each helping only a fraction of patients. Patients may face time-consuming drug trials while the disease is active, thus there ... -
Physiological hypoxia improves growth and functional differentiation of human intestinal epithelial organoids
Walaas, Gunnar Andreas; Gopalakrishnan, Shreya; Bakke, Ingunn; Skovdahl, Helene Kolstad; Flatberg, Arnar; Østvik, Ann Elisabeth; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2023)Background: The epithelium in the colonic mucosa is implicated in the pathophysiology of various diseases, including inflammatory bowel diseases and colorectal cancer. Intestinal epithelial organoids from the colon (colonoids) ... -
Profound gene expression changes in the epithelial monolayer of active ulcerative colitis and Crohn's disease
Sæterstad, Siri; Østvik, Ann Elisabet; Røyset, Elin Synnøve; Bakke, Ingunn; Sandvik, Arne Kristian; Granlund, Atle van Beelen (Peer reviewed; Journal article, 2022)In recent years it has become apparent that the epithelium is highly involved in inflammatory bowel disease (IBD) pathophysiology. The majority of gene expression studies of IBD are generated from heterogeneous biopsies, ... -
Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium
Gopalakrishnan, Shreya; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Roseth, Ingrid Aass; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Bakke, Ingunn; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2022)Major Histocompatibility Complex (MHC)-I and -II genes are upregulated in intestinal epithelial cells (IECs) during active inflammatory bowel diseases (IBD), but little is known about how IBD-relevant pro-inflammatory ... -
Transcriptomic Profiling of Collagenous Colitis Identifies Hallmarks of Nondestructive Inflammatory Bowel Disease
Escudero-hernandez, Celia; Granlund, Atle van Beelen; Bruland, Torunn; Sandvik, Arne Kristian; Koch, Stefan; Østvik, Ann Elisabet; Munch, Andreas (Peer reviewed; Journal article, 2021)Background and aims: The pathophysiology of the inflammatory bowel disease collagenous colitis (CC) is poorly described. Our aim was to use RNA sequencing of mucosal samples from patients with active CC, CC in remission, ... -
Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels
Thorsvik, Silje; Granlund, Atle van Beelen; Svendsen, Tarjei Dahl; Bakke, Ingunn; Røyset, Elin Synnøve; Flo, Trude Helen; Damås, Jan Kristian; Østvik, Ann Elisabet; Bruland, Torunn; Sandvik, Arne Kristian (Peer reviewed; Journal article, 2019)Neutrophil gelatinase‐associated lipocalin (NGAL), also known as Lipocalin 2, is an antimicrobial protein, encoded by the gene LCN2, strongly upregulated in inflammatory bowel disease (IBD) and a promising biomarker for ...