Blar i St. Olavs hospital på forfatter "Sandvig, Axel"
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Bridging the gap between fluid biomarkers for Alzheimer’s disease, model systems, and patients
Bjorkli, Christiana; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2020)Alzheimer’s disease (AD) is a debilitating neurodegenerative disease characterized by the accumulation of two proteins in fibrillar form: amyloid-β (Aβ) and tau. Despite decades of intensive research, we cannot yet pinpoint ... -
Combined targeting of pathways regulating synaptic formation and autophagy attenuates Alzheimer’s disease pathology in mice
Bjorkli, Christiana; Hemler, Mary Elizabeth; Julian, Joshua B; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2022)All drug trials completed to date have fallen short of meeting the clinical endpoint of significantly slowing cognitive decline in Alzheimer’s disease (AD) patients. In this study, we repurposed two FDA-approved drugs, ... -
Connectomics of morphogenetically engineered neurons as a predictor of functional integration in the ischemic brain
Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2019)Recent advances in cell reprogramming technologies enable the in vitro generation of theoretically unlimited numbers of cells, including cells of neural lineage and specific neuronal subtypes from human, including ... -
Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks
Valderhaug, Vibeke Devold; Heiney, Kristine; Huse Ramstad, Ola; Bråthen, Geir; Kuan, Wei-Li; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)A patterned spread of proteinopathy represents a common characteristic of many neurodegenerative diseases. In Parkinson’s disease (PD), misfolded forms of α-synuclein proteins accumulate in hallmark pathological inclusions ... -
Hallmarks of Criticality in Neuronal Networks Depend on Cell Type and the Temporal Resolution of Neuronal Avalanches
Heiney, Kristine; Valderhaug, Vibeke Devold; Huse Ramstad, Ola; Sandvig, Ioanna; Sandvig, Axel; Nichele, Stefano (Peer reviewed; Journal article, 2021)The human brain has a remarkable capacity for computation, and it has been theorized that this capacity arises from the brain self-organizing into the critical state, a dynamical state poised between ordered and dis- ordered ... -
In Vivo Microdialysis in Mice Captures Changes in Alzheimer´s Disease Cerebrospinal Fluid Biomarkers Consistent with Developing Pathology
Bjorkli, Christiana; Louet, Claire; Flo, Trude Helen; Hemler, Mary Elizabeth; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)Background: Preclinical models of Alzheimer’s disease (AD) can provide valuable insights into the onset and progression of the disease, such as changes in concentrations of amyloid-β (Aβ) and tau in cerebrospinal fluid ... -
Selective inhibition of excitatory synaptic transmission alters the emergent bursting dynamics of in vitro neural networks
Weir, Janelle Shari; Christiansen, Nicholas; Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2023) -
Silencing of activity during hypoxia improves functional outcomes in motor neuron networks in vitro
Fiskum, Vegard; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)The effects of hypoxia, or reduced oxygen supply, to brain tissue can be disastrous, leading to extensive loss of function. Deoxygenated tissue becomes unable to maintain healthy metabolism, which leads to increased ... -
Structuring a multi-nodal neural network in vitro within a novel design microfluidic chip
van de Wijdeven, Rosanne; Huse Ramstad, Ola; Bauer, Ulrich Stefan; Halaas, Øyvind; Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2018)Neural network formation is a complex process involving axon outgrowth and guidance. Axon guidance is facilitated by structural and molecular cues from the surrounding microenvironment. Micro-fabrication techniques can be ...