• Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study. 

      Fenstad, Mona H.; Ravlo, Erlend; Ianevski, Aleksandr; Starheim, Eirin Johannessen; Wang, Wei; Lysvand, Hilde; Smura, Teemu; Ji, Ping; Kivi, Gaily; Voolaid, Maia-Liisa; Plaan, Kati; Ustav, Mart; Ustav, Mart; Žusinaite, Eva; Tenson, Tanel; Kurg, Reet; Oksenych, Valentyn; Walstad, Kirsti; Nordbø, Svein Arne; Kaarbø, Mari; Ernits, Karin; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2023)
      Vaccinated convalescents do not develop severe COVID-19 after infection with new SARS-CoV-2 variants. We questioned how messenger RNA (mRNA) vaccination of convalescents provides protection from emerging virus variants. ...
    • Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis 

      Ianevski, Aleksandr; Kulesskiy, Evgeny; Krpina, Klara; Lou, Guofeng; Aman, Yahyah; Bugai, Andrii; Aasumets, Koit; Akimov, Yevhen; Bulanova, Daria; Gildemann, Kiira; Arutyunyan, Albert F.; Susova, Olga Yu.; Zhuze, Alexei L.; Ji, Ping; Wang, Wei; Holien, Toril; Bugge, Marit; Zusinaite, Eva; Oksenych, Valentyn; Lysvand, Hilde; Gerhold, Joachim M.; Bjørås, Magnar; Johansen, Pål; Waage, Anders; Heckman, Caroline A.; Fang, Evandro Fei; Kainov, Denis (Journal article; Peer reviewed, 2020)
      Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected or RNA/DNA-transfected cells provides rationale for investigating these apoptotic inducers further. We hypothesized that ...
    • Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer 

      Rabben, Hanne-Line; Andersen, Gøran Troseth; Ianevski, Aleksandr; Olsen, Magnus Kringstad; Kainov, Denis; Grønbech, Jon Erik; Wang, Timothy Cragin; Chen, Duan; Zhao, Chun-Mei (Peer reviewed; Journal article, 2021)
      Objective: The aim of the present study was repositioning of ivermectin in treatment of gastric cancer (GC) by computational prediction based on gene expression profiles of human and mouse model of GC and validations with ...
    • Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses 

      Ladner, Jason T.; Henson, Sierra N.; Boyle, Annalee S.; Engelbrektson, Anna L.; Fink, Zane W.; Rahee, Fatima; D'ambrozio, Jonathan; Schaecher, Kurt E.; Stone, Mars; Dong, Wenjuan; Dadwal, Sanjeet; Yu, Jianhua; Caligiuri, Michael A.; Cieplak, Piotr; Bjørås, Magnar; Fenstad, Mona H.; Nordbø, Svein Arne; Kainov, Denis; Muranaka, Norihito; Chee, Mark S.; Shiryaev, Sergey A.; Altin, John A. (Peer reviewed; Journal article, 2021)
      The SARS-CoV-2 proteome shares regions of conservation with endemic human coronaviruses (CoVs), but it remains unknown to what extent these may be cross-recognized by the antibody response. Here, we study cross-reactivity ...
    • Identification and Tracking of Antiviral Drug Combinations 

      Ianevski, Aleksandr; Yao, Rouan; Biza, Svetlana; Zusinaite, Eva; Mannik, Andres; Kivi, Gaily; Planken, Anu; Kurg, Kristiina; Tombak, Eva-Maria; Ustav, Mart Jr; Shtaida, Nastassia; Kulesskiy, Evgeny; Jo, Eunji; Yang, Jaewon; Lysvand, Hilde; Løseth, Kirsti; Oksenych, Valentyn; Aas, Per Arne; Tenson, Tanel; Vitkauskienė, Astra; Windisch, Marc P; Fenstad, Mona H.; Nordbø, Svein Arne; Ustav, Mart; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2020)
      Combination therapies have become a standard for the treatment for HIV and hepatitis C virus (HCV) infections. They are advantageous over monotherapies due to better efficacy, reduced toxicity, as well as the ability to ...
    • Neural signaling modulates metabolism of gastric cancer 

      Rabben, Hanne-Line; Andersen, Gøran Troseth; Olsen, Magnus Kringstad; Øverby, Anders; Ianevski, Aleksandr; Kainov, Denis; Wang, Timothy Cragin; Lundgren, Steinar; Grønbech, Jon Erik; Chen, Duan; Zhao, Chun-Mei (Peer reviewed; Journal article, 2021)
      Tumors comprise cancer cells and the associated stromal and immune/inflammatory cells, i.e., tumor microenvironment (TME). Here, we identify a metabolic signature of human and mouse model of gastric cancer and show that ...
    • Novel Synergistic Anti-Enteroviral Drug Combinations 

      Ianevski, Aleksandr; Zusinaite, Eva; Tenson, Tanel; Oksenych, Valentyn; Wang, Wei; Afset, Jan Egil; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2022)
      Background: Enterovirus infections affect people around the world, causing a range of illnesses, from mild fevers to severe, potentially fatal conditions. There are no approved treatments for enterovirus infections. Methods: ...
    • Potential Antiviral Options against SARS-CoV-2 Infection. Viruses. 

      Ianevski, Aleksandr; Yao, Rouan; Fenstad, Mona H.; Biza, Svetlana; Zusinaite, Eva; Reisberg, Tuuli; Lysvand, Hilde; Løseth, Kirsti; Landsem, Veslemøy Malm; Fossum, Janne; Erlandsen, Sten Even; Aas, Per Arne; Hagen, Lars; Pettersen, Caroline Hild; Tenson, Tanel; Afset, Jan Egil; Nordbø, Svein Arne; Bjørås, Magnar; Kainov, Denis; Oksenych, Valentyn (Peer reviewed; Journal article, 2020)
      As of June 2020, the number of people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the World Health Organization (WHO) and United ...