Blar i St. Olavs hospital på forfatter "Davies, Catharina de Lange"
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A Comparative Analysis of Orthotopic and Subcutaneous Pancreatic Tumour Models: Tumour Microenvironment and Drug Delivery
Lage Fernandez, Jessica; Årbogen, Sara Beate Stjern; Sadeghinia, Mohammadjavad; Haram, Karin Margrete; Snipstad, Sofie; Torp, Sverre Helge; Einen, Caroline; Mühlenpfordt, Melina; Maardalen, Matilde; Vikedal, Krister; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy, mainly due to its resistance to chemotherapy and its complex tumour microenvironment characterised by stromal desmoplasia. There is a need for new ... -
Intraperitoneal administration of cabazitaxel-loaded nanoparticles in peritoneal metastasis models
Hyldbakk, Astrid; Fleten, Karianne Giller; Snipstad, Sofie; Åslund, Andreas; Davies, Catharina de Lange; Flatmark, Kjersti; Mørch, Ýrr Asbjørg (Peer reviewed; Journal article, 2023)Colorectal and ovarian cancers frequently develop peritoneal metastases with few treatment options. Intraperitoneal chemotherapy has shown promising therapeutic effects, but is limited by rapid drug clearance and systemic ... -
Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models
Sulheim, Einar; Kim, Jana; van Wamel, Annemieke; Kim, Eugene; Snipstad, Sofie; Vidic, Igor; Grimstad, Ingeborg; Widerøe, Marius; Torp, Sverre Helge; Lundgren, Steinar; Waxman, David J.; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased ... -
Multi-timescale microscopy methods for the characterization of fluorescently-labeled microbubbles for ultrasound-triggered drug release
Nawijn, Charlotte; Segers, Tim; Lajoinie, Guillaume; Mørch, Ýrr Asbjørg; Berg, Sigrid; Snipstad, Sofie; Davies, Catharina de Lange; Versluis, Michel (Peer reviewed; Journal article, 2021)Microbubble contrast agents hold great promise for drug delivery applications with ultrasound. Encapsulating drugs in nanoparticles reduces systemic toxicity and increases circulation time of the drugs. In a novel approach ... -
Sonopermeation Enhances Uptake and Therapeutic Effect of Free and Encapsulated Cabazitaxel
Snipstad, Sofie; Mørch, Ýrr; Sulheim, Einar; Åslund, Andreas; Pedersen, André; Hansen, Rune; Davies, Catharina de Lange; Berg, Sigrid (Peer reviewed; Journal article, 2021)Delivery of drugs and nanomedicines to tumors is often heterogeneous and insufficient and, thus, of limited efficacy. Microbubbles in combination with ultrasound have been found to improve delivery to tumors, enhancing ... -
Sonopermeation with nanoparticle-stabilized microbubbles reduces solid stress and improves nanomedicine delivery to tumors
Sulheim, Einar; Hanson, Ingunn; Snipstad, Sofie; Vikedal, Krister; Mørch, Ýrr Asbjørg; Boucher, Yves; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)Drug delivery to tumors is challenging due to biological barriers obstructing effective delivery. Sonopermeation with ultrasound and microbubbles has been shown to improve therapeutic effect of many classes of drugs, but ... -
Ultrasound and Microbubbles Increase the Uptake of Platinum in Murine Orthotopic Pancreatic Tumors
Haram, Karin Margrete; Snipstad, Sofie; Berg, Sigrid; Mjønes, Patricia; Rønne, Elin; Lage Fernandez, Jessica; Mühlenpfordt, Melina; Davies, Catharina de Lange (Peer reviewed; Journal article, 2023)Objective Currently available cytotoxic treatments have limited effect on pancreatic ductal adenocarcinoma (PDAC) because desmoplastic stroma limits drug delivery. Efforts have been made to overcome these barriers by drug ... -
Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine
Snipstad, Sofie; Vikedal, Krister; Maardalen, Matilde; Kurbatskaya, Anna; Sulheim, Einar; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)Successful delivery of drugs and nanomedicine to tumors requires a functional vascular network, extravasation across the capillary wall, penetration through the extracellular matrix, and cellular uptake. Nanomedicine has ... -
Ultrasound and microbubbles to beat barriers in tumors: Improving delivery of nanomedicine
Snipstad, Sofie; Vikedal, Krister; Maardalen, Matilde; Kurbatskaya, Anna; Sulheim, Einar; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)Successful delivery of drugs and nanomedicine to tumors requires a functional vascular network, extravasation across the capillary wall, penetration through the extracellular matrix, and cellular uptake. Nanomedicine has ... -
Ultrasound-Mediated Delivery of Chemotherapy into the Transgenic Adenocarcinoma of the Mouse Prostate Model
Fagerland, Stein-Martin Tilrum; Berg, Sigrid; Hill, Deborah Katherine; Snipstad, Sofie; Sulheim, Einar; Hyldbakk, Astrid; Kim, Jana; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)Ultrasound (US) in combination with microbubbles (MB) has had promising results in improving delivery of chemotherapeutic agents. However, most studies are done in immunodeficient mice with xenografted tumors. We used two ...