Blar i St. Olavs hospital på forfatter "Carlsen, Sven Magnus"
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The Artificial Pancreas: Two Alternative Approaches to Achieve a Fully Closed Loop System with Optimal Glucose Control
Åm, Marte Kierulf; Teigen, Ingrid Anna; Riaz, Misbah; Fougner, Anders Lyngvi; Christiansen, Sverre Christian; Carlsen, Sven Magnus (Peer reviewed; Journal article, 2023)Introduction Diabetes mellitus type 1 is a chronic disease that implies mandatory external insulin delivery. The patients must monitor their blood glucose levels and administer appropriate insulin boluses to keep their ... -
Basic lifestyle advice to individuals at high risk of type 2 diabetes: a 2-year population-based diabetes prevention study. The DE-PLAN intervention in the HUNT Study, Norway
Jølle, Anne; Åsvold, Bjørn Olav; Holmen, Jostein; Carlsen, Sven Magnus; Tuomilehto, Jaakko; Bjørngaard, Johan Håkon; Midthjell, Kristian (Journal article; Peer reviewed, 2018)Objective Among individuals at high risk for diabetes identified through a population survey, we performed an intervention study with basic lifestyle advice aiming to prevent diabetes. Research design and methods Among ... -
The effect of glucagon on local subcutaneous blood flow in non-diabetic volunteers; a proof-of-concept study
Åm, Marte Kierulf; Munkerud, Erlend Yttersian; Berge, Mathilde Hallem; Christiansen, Sverre Christian; Carlsen, Sven Magnus (Peer reviewed; Journal article, 2022)Introduction Glucagon and insulin are the two most important hormones for glucose metabolism and have been incorporated in the dual-hormonal artificial pancreas, a device for automated glucose regulation for people with ... -
Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery: A Randomized Clinical Trial
Hara, Sozaburo; Andresen, Hege; Solheim, Ole; Carlsen, Sven Magnus; Sundstrøm, Terje; Lønne, Greger; Vangen-Lønne, Vetle; Taraldsen, Kristin; Tronvik, Erling Andreas; Øie, Lise Rystad; Gulati, Agnete Malm; Sagberg, Lisa Millgård; Jakola, Asgeir Store; Solberg, Tore; Nygaard, Øystein Petter; Salvesen, Øyvind; Gulati, Sasha (Peer reviewed; Journal article, 2022)Importance: The use of spinal cord stimulation for chronic pain after lumbar spine surgery is increasing, yet rigorous evidence of its efficacy is lacking. Objective: To investigate the efficacy of spinal cord burst ... -
HbA1c as screening for gestational diabetes mellitus in women with polycystic ovary syndrome
Odsæter, Ingrid Hov; Åsberg, Arne; Vanky, Eszter; Carlsen, Sven Magnus (Journal article; Peer reviewed, 2015)Background Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes such as preeclampsia and macrosomia. Women with polycystic ovary syndrome (PCOS) are at increased risk of developing GDM. ... -
Hemoglobin A1c as screening for gestational diabetes mellitus in Nordic Caucasian women
Odsæter, Ingrid Hov; Åsberg, Arne; Vanky, Eszter; Mørkved, Siv; Stafne, Signe Nilssen; Salvesen, Kjell Å; Carlsen, Sven Magnus (Peer reviewed; Journal article, 2016)Background Gestational diabetes mellitus (GDM) increases the risk for preeclampsia and macrosomia. GDM is conventionally diagnosed by an oral glucose tolerance test (OGTT). Hemoglobin A1c (HbA1c) is a marker for the ... -
Incidence and Case Fatality of Aneurysmal Subarachnoid Hemorrhage Admitted to Hospital Between 2008 and 2014 in Norway
Øie, Lise Rystad; Solheim, Ole; Majewska, Paulina Luiza; Nordseth, Trond; Müller, Tomm Brostrup; Carlsen, Sven Magnus; Jensberg, Heidi; Salvesen, Øyvind; Gulati, Sasha (Peer reviewed; Journal article, 2020)Background To provide age- and sex-specific incidence and case fatality rates for non-traumatic aneurysmal subarachnoid hemorrhage (aSAH) in Norway. We also studied time trends in incidence and case fatality, as well as ... -
Intraperitoneal insulin administration in pigs: Effect on circulating insulin and glucose levels
Dirnena-Fusini, Ilze; Åm, Marte Kierulf; Fougner, Anders Lyngvi; Carlsen, Sven Magnus; Christiansen, Sverre Christian (Peer reviewed; Journal article, 2021)Introduction The effect of intraperitoneal insulin infusion has limited evidence in the literature. Therefore, the aim of the study was to investigate the pharmacokinetics and pharmacodynamics of different intraperitoneal ... -
Maternal PCOS status and metformin in pregnancy: Steroid hormones in 5–10 years old children from the PregMet randomized controlled study
Hanem, Liv Guro Engen; Salvesen, Øyvind; Madsen, Andre; Sagen, Jørn Vegard; Mellgren, Gunnar; Juliusson, Petur Benedikt; Carlsen, Sven Magnus; Vanky, Eszter; Ødegård, Rønnaug (Peer reviewed; Journal article, 2021)Objective Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with potential effects on offspring both genetically and through altered intrauterine environment. Metformin, which ameliorate hormonal disturbances ... -
Metformin in Pregnancy Study (MiPS): protocol for a systematic review with individual patient data meta-analysis
Mousa, Aya; Løvvik, Tone Shetelig; Ijas, Hilkka; Carlsen, Sven Magnus; Morin-Papunen, Laure; Tertti, Kristiina; Rönnema, Tapani; Syngelaki, Argyro; Nicolaides, Kypros; Shehata, Hassan; Burden, Chirsty; Rowan, Janet; Norman, Jane E.; Dodd, Jodie M.; Hague, William; Vanky, Eszter; Teede, Helena J. (Peer reviewed; Journal article, 2020)Introduction: Gestational diabetes mellitus (GDM) is a common disorder of pregnancy and contributes to adverse pregnancy outcomes. Metformin is often used for the prevention and management of GDM; however, its use in ... -
Pharmacokinetics of Intraperitoneally Delivered Glucagon in Pigs: A Hypothesis of First Pass Metabolism
Teigen, Ingrid Anna; Åm, Marte Kierulf; Carlsen, Sven Magnus; Christiansen, Sverre Christian (Peer reviewed; Journal article, 2021)Background and Objective Artificial pancreases administering low-dose glucagon in addition to insulin have the scope to improve glucose control in patients with diabetes mellitus type 1. If such a device were to deliver ... -
Physiological effects of intraperitoneal versus subcutaneous insulin infusion in patients with diabetes mellitus type 1: A systematic review and meta-analysis
Dirnena-Fusini, Ilze; Åm, Marte Kierulf; Fougner, Anders Lyngvi; Carlsen, Sven Magnus; Christiansen, Sverre Christian (Peer reviewed; Journal article, 2021)The intraperitoneal route of administration accounts for less than 1% of insulin treatment regimes in patients with diabetes mellitus type 1 (DM1). Despite being used for decades, a systematic review of various physiological ... -
Risk of intracranial hemorrhage (RICH) in users of oral antithrombotic drugs: Nationwide pharmacoepidemiological study
Gulati, Sasha; Solheim, Ole; Carlsen, Sven Magnus; Øie, Lise Rystad; Jensberg, Heidi; Gulati, Agnete Malm; Madsbu, Mattis Aleksander; Giannadakis, Charalampis; Jakola, Asgeir Store; Salvesen, Øyvind (Journal article; Peer reviewed, 2018)Background The risks of intracranial haemorrhage (ICH) associated with antithrombotic drugs outside clinical trials are gaining increased attention. The aim of this nationwide study was to investigate the risk of ICH ... -
Severe bradycardia and hypotension in anaesthetized pigs: Possible interaction between octreotide, xylazine, and atropine: A case series
Åm, Marte Kierulf; Teigen, Ingrid Anna; Carlsen, Sven Magnus; Christiansen, Sverre Christian (Peer reviewed; Journal article, 2023)Pigs are common animal models in diabetes research. Streptozotocin-induced destruction of pancreatic β-cells is used to induce diabetes in conscious pigs. However, in short-term non-recovery experiments, suppression of ... -
Surgery for herniated lumbar disc in private vs public hospitals: A pragmatic comparative effectiveness study
Madsbu, Mattis Aleksander; Salvesen, Øyvind; Carlsen, Sven Magnus; Westin, Steinar; Onarheim, Kristian; Nygaard, Øystein Petter; Solberg, Tore; Gulati, Sasha (Peer reviewed; Journal article, 2020)Background There is limited evidence on the comparative performance of private and public healthcare. Our aim was to compare outcomes following surgery for lumbar disc herniation (LDH) in private versus public hospitals. ... -
Uterine artery Doppler in pregnancy: Women with PCOS compared to healthy controls
Stridsklev, Solhild; Salvesen, Øyvind; Salvesen, Kjell Å; Carlsen, Sven Magnus; Vanky, Eszter (Journal article; Peer reviewed, 2018)The objective of this study was to investigate possible differences in uterine artery pulsatility index (UtAPI) between pregnant women with PCOS and healthy controls and to explore possible effects of metformin on UtAPI. ... -
Vasodilatory effects of glucagon: A possible new approach to enhanced subcutaneous insulin absorption in artificial pancreas devices
Teigen, Ingrid Anna; Riaz, Misbah; Åm, Marte Kierulf; Christiansen, Sverre Christian; Carlsen, Sven Magnus (Peer reviewed; Journal article, 2022)Patients with diabetes mellitus type 1 depend on exogenous insulin to keep their blood glucose concentrations within the desired range. Subcutaneous bihormonal artificial pancreas devices that can measure glucose concentrations ...