Blar i St. Olavs hospital på forfatter "Afset, Jan Egil"

Viser treff 1-19 av 19

    • Detailed stratified GWAS analysis for severe COVID-19 in four European populations 

      Degenhardt, Frauke; Ellinghaus, David; Juzenas, Simonas; Lerga-Jaso, Jon; Wendorff, Mareike; Maya-Miles, Douglas; Uellendahl-Werth, Florian; ElAbd, Hesham; Lenning, Ole Bernt; Myhre, Ronny; Vadla, May Sissel; Holten, Aleksander Rygh; Kildal, Anders Benjamin; Lind, Andreas; Dyrhol-Riise, Anne Ma; Hoff, Dag Arne Lihaug; Müller, Fredrik; Solligård, Erik; Holter, Jan Cato; Afset, Jan Egil; Damås, Jan Kristian; Bergan, Jonas; Risnes, Kari; Muller, Karl Erik; Tonby, Kristian; Heggelund, Lars; Gustad, Lise Tuset; Grimsrud, Marit Mæhle; Dudman, Susanne Gjeruldsen; Folseraas, Trine; Skogen, Vegard; Hov, Johannes Espolin Roksund; Karlsen, Tom Hemming; Rühlemann, Malte C.; Arora, Jatin; Özer, Onur; Wacker, Eike Matthias; Wienbrandt, Lars; Ortiz, Aron Blandino; de Salazar, Adolfo; Chercoles, Adolfo Garrido; Palom, Adriana; Ruiz, Agustin; Garzia-Fernandez, Alba-Estela; Blanco-Grau, Albert; Mantovani, Alberto; Zanella, Alberto; Mayer, Alena; Bandera, Alessandra; Franke, Andre (Peer reviewed; Journal article, 2022)
      Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease ...

    • Epidemiological and clinical characteristics of immunocompromised patients infected with Pneumocystis jirovecii in a twelve-year retrospective study from Norway 

      Grønseth, Stine; Rogne, Tormod; Hannula, Raisa; Åsvold, Bjørn Olav; Afset, Jan Egil; Damås, Jan Kristian (Journal article; Peer reviewed, 2021)

    • High levels of discordant antimicrobial therapy in hospital-acquired bloodstream infections is associated with increased mortality in an intensive care, low antimicrobial resistance setting 

      Waagsbø, Bjørn; Stuve, Nora; Afset, Jan Egil; Klepstad, Pål; Mo, Skule; Heggelund, Lars; Damås, Jan Kristian (Peer reviewed; Journal article, 2022)
      Background Bloodstream infections (BSI) occur frequently and are associated with severe outcomes. In this study we aimed to investigate proportions of patients that received discordant empirical antimicrobial therapy and ...

    • Incidence of invasive Group B Streptococcal infection and the risk of infant death and cerebral palsy: a Norwegian Cohort Study 

      Mynarek, Maren; Bjellmo, Solveig; Lydersen, Stian; Afset, Jan Egil; Andersen, Guro Lillemoen; Vik, Torstein (Peer reviewed; Journal article, 2020)
      Background Group B Streptococcus (GBS) is the leading cause of invasive neonatal infection worldwide. In high-income countries mortality rates are 4–10%, and among survivors of GBS meningitis 30–50% have neurodevelopmental ...

    • Kodepraksis ved sepsis 2008–21 

      Skei, Nina Vibeche; Afset, Jan Egil; Ehrnström, Anna Greta Birgitta; Nessan, Bente Sofie; Damås, Jan Kristian; Nilsen, Tom Ivar Lund; Gustad, Lise Tuset (Journal article; Peer reviewed, 2024)
      Bakgrunn:Sepsis har høy insidens og mortalitet. For planlegging av helsetjenester og i forskning trengs presise data, og det er behov for å kartlegge kodepraksis i Norge. Materiale og metode: Alle personer over 17 år som ...

    • Mapping the human genetic architecture of COVID-19 

      Niemi, Mari E.K.; Karjalainen, Juha; Liao, Rachel G.; Neale, Benjamin M.; Daly, Mark; Ganna, Andrea; Pathak, Gita A.; Andrews, Shea J.; Kanai, Masahiro; Veerapen, Kumar; Fernandez-Cadenas, Israel; Schulte, Eva C.; Striano, Pasquale; Afset, Jan Egil; Solligård, Erik; Damås, Jan Kristian; Risnes, Kari; Bettini, Laura Rachele; Gustad, Lise Tuset; Holter, Jan Cato; Hov, Johannes Espolin Roksund; Karlsen, Tom Hemming; Folseraas, Trine; Holten, Aleksander Rygh; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Lind, Andreas; Müller, Fredrik; Dudman, Susanne Gjeruldsen; Grimsrud, Marit Mæhle; Vadla, May Sissel; Myhre, Ronny; Kildal, Anders Benjamin; Hoff, Dag Arne Lihaug; Muller, Karl Erik; Heggelund, Lars; Bergan, Jonas; Skogen, Vegard (Journal article; Peer reviewed, 2021)
      The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity ...

    • Mortality and neurodevelopmental outcome after invasive group B streptococcal infection in infants 

      Mynarek, Maren; Vik, Torstein; Andersen, Guro Lillemoen; Brigtsen, Anne Karin; Hollung, Sandra Julsen; Larose, Tricia L; Lydersen, Stian; Olsen, Lene Christin; Strøm, Marianne; Afset, Jan Egil (Peer reviewed; Journal article, 2023)
      Aim: To assess case fatality rate (CFR), infant mortality, and long-term neurodevelopmental disorders (NDDs) after invasive group B streptococcal (GBS; Streptococcus agalactiae) infection in infants. Method: Children born ...

    • Novel Synergistic Anti-Enteroviral Drug Combinations 

      Ianevski, Aleksandr; Zusinaite, Eva; Tenson, Tanel; Oksenych, Valentyn; Wang, Wei; Afset, Jan Egil; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2022)
      Background: Enterovirus infections affect people around the world, causing a range of illnesses, from mild fevers to severe, potentially fatal conditions. There are no approved treatments for enterovirus infections. Methods: ...

    • Outbreak of tularaemia in central Norway, January to March 2011 

      Larssen, Kjersti Wik; Afset, Jan Egil; Heier, Berit Tafjord; Krogh, Truls; Handeland, Kjell; Vikøren, Turid; Bergh, Kåre (Journal article; Peer reviewed, 2011)
      From January to March 2011, 39 cases of tularaemia were diagnosed in three counties in central Norway: 21 cases of oropharyngeal type, 10 cases of glandular/ulceroglandular type, two of respiratory and two of typhoid type. ...

    • Phenotypic and genotypic characterisation of thymine auxotrophy in Escherichia coli isolated from a patient with recurrent bloodstream infection 

      Jakovljev, Aleksandra; Afset, Jan Egil; Haugum, Kjersti; Steinum, Harald Otto; Rønning, Torunn Gresdal; Samuelsen, Ørjan; Ås, Christina Gabrielsen (Peer reviewed; Journal article, 2022)
      Introduction Thymine auxotrophic in vitro mutants of Escherichia coli were first reported in the mid-20th century. Later, thymine-dependent clinical strains of E. coli as well as other Enterobacterales, Enterococcus ...

    • Phylogeographical pattern of Francisella tularensis in a nationwide outbreak of tularaemia in Norway, 2011 

      Afset, Jan Egil; Larssen, Kjersti Wik; Bergh, Kåre; Lärkeryd, A; Sjodin, A; Johansson, A; Forsman, M (Journal article; Peer reviewed, 2015)
      In 2011, a nationwide outbreak of tularaemia occurred in Norway with 180 recorded cases. It was associated with the largest peak in lemming density seen in 40 years. Francisella tularensis was isolated from 18 patients. ...

    • Potential Antiviral Options against SARS-CoV-2 Infection. Viruses. 

      Ianevski, Aleksandr; Yao, Rouan; Fenstad, Mona H.; Biza, Svetlana; Zusinaite, Eva; Reisberg, Tuuli; Lysvand, Hilde; Løseth, Kirsti; Landsem, Veslemøy Malm; Fossum, Janne; Erlandsen, Sten Even; Aas, Per Arne; Hagen, Lars; Pettersen, Caroline Hild; Tenson, Tanel; Afset, Jan Egil; Nordbø, Svein Arne; Bjørås, Magnar; Kainov, Denis; Oksenych, Valentyn (Peer reviewed; Journal article, 2020)
      As of June 2020, the number of people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the World Health Organization (WHO) and United ...

    • Predicting In-Hospital Death from Derived EHR Trajectory Features 

      Bopche, Rajeev; Gustad, Lise Tuset; Afset, Jan Egil; Damås, Jan Kristian; Nytrø, Øystein (Chapter, 2024)
      Medical histories of patients can provide insight into the immediate future of a patient. While most studies propose to predict survival from vital signs and hospital tests within one episode of care, we carry out selective ...

    • Prelabor rupture of membranes and the association with cerebral palsy in term born children: A national registry-based cohort study. 

      Mynarek, Maren; Bjellmo, Solveig; Lydersen, Stian; Strand, Kristin Melheim; Afset, Jan Egil; Andersen, Guro Lillemoen; Vik, Torstein (Journal article; Peer reviewed, 2020)
      Background Guidelines regarding management of prelabor rupture of membranes (PROM) at term vary between immediate induction and expectant management. A long interval between PROM and delivery increases the risk for ...

    • Quality of care for peripheral intravenous catheters (PIVCs) in Nepal: A cross-sectional study on feasibility and inter-rater agreement of the Peripheral Intravenous Catheters-mini Questionnaire (PIVC-miniQ) in a tertiary care hospital 

      Shrestha, Sulekha; Vieler, Johannes; Haug, Nikolai Juliussen; Afset, Jan Egil; Høvik, Lise Husby; Lydersen, Stian; Gustad, Lise Tuset (Peer reviewed; Journal article, 2021)
      Objectives There is a lack of data regarding the quality of peripheral intravenous catheter (PIVC)-related care from low-income and middle-income countries, even though the use of PIVCs may lead to local or severe systemic ...

    • Role of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort 

      Grønseth, Stine; Rogne, Tormod; Heggelund, Lars; Åsvold, Bjørn Olav; Afset, Jan Egil; Damås, Jan Kristian (Peer reviewed; Journal article, 2023)
      Objectives This study aimed to explore the role of fungal burden in risk stratification of patients without HIV-negative patients with Pneumocystis pneumonia (PCP). Methods This was a retrospective analysis of the ...

    • Semiquantitative Real-Time PCR to Distinguish Pneumocystis Pneumonia from Colonization in a Heterogeneous Population of HIV-Negative Immunocompromised Patients 

      Grønseth, Stine; Rogne, Tormod; Hannula, Raisa; Åsvold, Bjørn Olav; Afset, Jan Egil; Damås, Jan Kristian (Peer reviewed; Journal article, 2021)
      Pneumocystis jirovecii is a threat to iatrogenically immunosuppressed individuals, a heterogeneous population at rapid growth. We assessed the ability of an in-house semiquantitative real-time PCR assay to discriminate ...

    • The Streptococcus agalactiae R3 surface protein is encoded by sar5 

      Basson, Adelle; Olaisen, Camilla; Selvik, Linn-Karina M.; Lyng, Randi Valsø; Lysvand, Hilde; Gidon, Alexandre; Ås, Christina Gabrielsen; Afset, Jan Egil; Dragset, Marte Singsås (Peer reviewed; Journal article, 2022)
      Streptococcus agalactiae (group B streptococcus; GBS) is an important human pathogen causing pneumonia, sepsis and meningitis in neonates, as well as infections in pregnant women, immunocompromised individuals, and the ...

    • Use of Sysmex UF-5000 flow cytometry in rapid diagnosis of urinary tract infection and the importance of validating carryover rates against bacterial count cut-off 

      Haugum, Kjersti; Haugan, Maria Schei; Skage, Jannicke; Tetik, Mariann Havdahl; Jakovljev, Aleksandra; Nilsen, Hans-Johnny; Afset, Jan Egil (Peer reviewed; Journal article, 2021)
      Introduction. Urinary tract infections are common bacterial infections worldwide. Urine culture is the gold standard method to identify and quantify the presence or absence of bacteria in urine. Flow cytometry, which can ...