• Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity 

      Hotz, Adriana L.; Jamali, Ahmed; Rieser, Nicolas N.; Niklaus, Stephanie; Aydin, Ecem; Myren-Svelstad, Sverre; Lalla, Laetitia Noelle Patricia; Jurisch-Yaksi, Nathalie; Yaksi, Emre; Neuhauss, Stephan C.F. (Peer reviewed; Journal article, 2021)
      Astroglial excitatory amino acid transporter 2 (EAAT2, GLT-1, and SLC1A2) regulates the duration and extent of neuronal excitation by removing glutamate from the synaptic cleft. Hence, an impairment in EAAT2 function could ...
    • Past, present and future of zebrafish in epilepsy research 

      Yaksi, Emre; Jamali, Ahmed; Diaz Verdugo, Carmen; Jurisch-Yaksi, Nathalie (Journal article; Peer reviewed, 2021)
      Animal models contribute greatly to our understanding of brain development and function as well as its dysfunction in neurological diseases. Epilepsy research is a very good example of how animal models can provide us with ...
    • The spectrum of pyridoxine dependent epilepsy across the age span: A nationwide retrospective observational study 

      Jamali, Ahmed; Kristensen, Erle; Tangeraas, Trine; Arntsen, Vibeke; Sikric, Alma; Kupliauskiene, Guste; Myren-Svelstad, Sverre; Berland, Siren; Sejersted, Yngve; Gerstner, Thorsten Alfons; Hassel, Bjørnar; Bindoff, Laurence Albert; Brodtkorb, Eylert August (Peer reviewed; Journal article, 2023)
      Background Pyridoxine-dependent epilepsy (PDE) is a rare seizure disorder usually presenting with neonatal seizures. Most cases are caused by biallelic pathogenic ALDH7A1variants. While anti-seizure medications are ...