• Are there predilection sites for intracranial meningioma? A population-based atlas 

      Hosainey, Sayied Abdol Mohieb; Bouget, David; Reinertsen, Ingerid; Sagberg, Lisa Millgård; Torp, Sverre Helge; Jakola, Asgeir Store; Solheim, Ole (Peer reviewed; Journal article, 2021)
      Meningioma is the most common benign intracranial tumor and is believed to arise from arachnoid cap cells of arachnoid granulations. We sought to develop a population-based atlas from pre-treatment MRIs to explore the ...
    • Depression and ability to work after vestibular schwannoma surgery: a nationwide registry-based matched cohort study on antidepressants, sedatives, and sick leave 

      Thurin, Erik; Förander, Petter; bartek, Jiri Jr.; Gulati, Sasha; Rydén, Isabelle; Smits, Anja; Hesselager, Göran; Salvesen, Øyvind; Jakola, Asgeir Store (Peer reviewed; Journal article, 2021)
      Background In patients with vestibular schwannomas (VS), tumor control is often achieved, and life expectancy is relatively good. The main risks of surgical treatment are hearing loss and facial nerve function. The occurrence ...
    • Determinants for Effective ALECSAT Immunotherapy Treatment on Autologous Patient-Derived Glioblastoma Stem Cells 

      Wenger, Anna; Werlenius, Katja; Hallner, Alexander; Fredrik Bergh, Thoren; Farahmand, Dan; Tisell, Magnus; Smits, Anja; Rydenhag, Bertil; Jakola, Asgeir Store; Caren, Helena (Peer reviewed; Journal article, 2018)
      Glioblastoma (GBM) is the most aggressive primary brain tumor with a median survival of less than 15 months, emphasizing the need for better treatments. Immunotherapy as a treatment for improving or aiding the patient’s ...
    • Development and external validation of a clinical prediction model for functional impairment after intracranial tumor surgery 

      Staartjes, Victor E.; Broggi, Morgan; Zattra, Costanza Maria; Vasella, Flavio; Velz, Julia; Schiavolin, Silvia; Serra, Carlo; Bartek, Jiri; Fletcher-Sandersjöö, Alexander; Förander, Petter; Kalasauskas, Darius; Renovanz, Mirjam; Ringel, Florian; Brawanski, Konstantin R.; Kerschbaumer, Johannes; Freyschlag, Christian F.; Jakola, Asgeir Store; Sjåvik, Kristin; Solheim, Ole; Schatlo, Bawarjan; Sachkova, Alexandra; Bock, Hans Christoph; Hussein, Abdelhalim; Rohde, Veit; Broekman, Marike L.D.; Nogarede, Claudine O.; Lemmens, Cynthia M.C.; Kernbach, Julius M.; Neuloh, Georg; Bozinov, Oliver; Krayenbühl, Niklaus; Sarnthein, Johannes; Ferroli, Paolo; Regli, Luca; Stienen, Martin N. (Peer reviewed; Journal article, 2021)
      OBJECTIVE Decision-making for intracranial tumor surgery requires balancing the oncological benefit against the risk for resection-related impairment. Risk estimates are commonly based on subjective experience and generalized ...
    • DNA methylation profiling for molecular classification of adult diffuse lower-grade gliomas 

      Ferreyra Vega, Sandra; Olsson Bontell, Thomas; Corell, Alba; Smits, Anja; Jakola, Asgeir Store; Carén, Helena (Peer reviewed; Journal article, 2021)
      Background - DNA methylation profiling has facilitated and improved the classification of a wide variety of tumors of the central nervous system. In this study, we investigated the potential utility of DNA methylation ...
    • Does risk of brain cancer increase with intracranial volume? A population-based case control study 

      Fyllingen, Even Hovig; Hansen, Tor Ivar; Jakola, Asgeir Store; Håberg, Asta; Salvesen, Øyvind; Solheim, Ole (Journal article; Peer reviewed, 2018)
      Background Glioma is the most common primary brain tumor and is believed to arise from glial stem cells. Despite large efforts, there are limited established risk factors. It has been suggested that tissue with more ...
    • Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients with Recurrent Glioblastoma: A Randomized Clinical Trial 

      Werlenius, Katja; Kinhult, Sara; Solheim, Tora S; Magelssen, Henriette; Löfgren, David; Mudaisi, Munila; Hylin, Sofia; Bartek, Jiri; Strandéus, Michael; Lindskog, Magnus; Rashid, Havyan Bahroz; Carstam, Louise; Gulati, Sasha; Solheim, Ole Skeidsvoll; Salvesen, Øyvind Olav; Jakola, Asgeir Store (Peer reviewed; Journal article, 2023)
      Importance Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for the treatment of glioblastoma. Objective To evaluate the efficacy and safety of ...
    • Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery: A Randomized Clinical Trial 

      Hara, Sozaburo; Andresen, Hege; Solheim, Ole; Carlsen, Sven Magnus; Sundstrøm, Terje; Lønne, Greger; Vangen-Lønne, Vetle; Taraldsen, Kristin; Tronvik, Erling Andreas; Øie, Lise Rystad; Gulati, Agnete Malm; Sagberg, Lisa Millgård; Jakola, Asgeir Store; Solberg, Tore; Nygaard, Øystein Petter; Salvesen, Øyvind; Gulati, Sasha (Peer reviewed; Journal article, 2022)
      Importance: The use of spinal cord stimulation for chronic pain after lumbar spine surgery is increasing, yet rigorous evidence of its efficacy is lacking. Objective: To investigate the efficacy of spinal cord burst ...
    • Functional outcome and survival following spontaneous intracerebral hemorrhage: A retrospective population-based study 

      Øie, Lise Rystad; Madsbu, Mattis Aleksander; Solheim, Ole; Jakola, Asgeir Store; Giannadakis, Charalampis; Vorhaug, Anders; Padayachy, Llewellyn; Jensberg, Heidi; Dodick, David W.; Salvesen, Øyvind; Gulati, Sasha (Journal article; Peer reviewed, 2018)
      Background Accurate and reliable clinical and radiological predictors of intracerebral hemorrhage (ICH) outcomes are needed to optimize treatment of ICH. The aim of this study was to investigate functional outcome and ...
    • Impact of meningioma surgery on use of antiepileptic, antidepressant, and sedative drugs: A Swedish nationwide matched cohort study 

      Thurin, Erik; Rydén, Isabelle; Skoglund, Thomas; Smits, Anja; Gulati, Sasha; Hesselager, Göran; Bartek, Jiri Jr.; Henriksson, Roger; Salvesen, Øyvind; Jakola, Asgeir Store (Peer reviewed; Journal article, 2021)
      Background: Meningioma is the most common primary intracranial tumor and surgery is the main treatment modality. As death from lack of tumor control is rare, other outcome measures like anxiety, depression and post-operative ...
    • Investigating survival, quality of life and cognition in PROton versus photon therapy for IDH- mutated diffuse grade 2 and 3 GLIOmas (PRO-GLIO): a randomised controlled trial in Norway and Sweden 

      Heggebø, Liv Cathrine; Borgen, Ida Maria Henriksen; Rylander, Hillevi; Kiserud, Cecilie E.; Nordenmark, Tonje Kristin Haug; Hellebust, Taran Annette Paulsen; Evensen, Morten Egeberg; Gustavsson, Magnus; Ramberg, Christina; Sprauten, Mette; Magelssen, Henriette; Blakstad, Hanne; Moorthy, Janani; Andersson, Karin; Raunert, Ingela; Henry, Thomas; Moe, Cecilie; Granlund, Carin; Goplen, Dorota; Brekke, Jorunn; Johannessen, Tor-Christian Aase; Solheim, Tora S; Marienhagen, Kirsten; Humberset, Øyvind; Bergström, Per; Agrup, Måns; Dahl, Ludvig; Gubanski, Michael; Gojon, Helene; Brahme, Carl-Johan; Rydén, Isabelle; Jakola, Asgeir Store; Vik-Mo, Einar O.; Lie, Hanne Cathrine; Asphaug, Lars; Hervani, Maziar; Kristensen, Ingrid; Rüegg, Corina Silvia; Olsen, Inge Christoffer; Ledal, Rolf J; Degsell, Eskil; Werlenius, Katja; Blomstrand, Malin; Brandal, Petter (Peer reviewed; Journal article, 2023)
      Abstract Introduction The use of proton therapy increases globally despite a lack of randomised controlled trials demonstrating its efficacy and safety. Proton therapy enables sparing of non-neoplastic tissue from ...
    • Is intracranial volume a risk factor for IDH-mutant low-grade glioma? A case-control study 

      Sagberg, Lisa Millgård; Fyllingen, Even Hovig; Hansen, Tor Ivar; Strand, Per Sveino; Håvik, Aril Løge; Sundstrøm, Terje; Corell, Alba; Jakola, Asgeir Store; Salvesen, Øyvind; Solheim, Ole (Peer reviewed; Journal article, 2022)
      Purpose Risk of cancer has been associated with body or organ size in several studies. We sought to investigate the relationship between intracranial volume (ICV) (as a proxy for lifetime maximum brain size) and risk of ...
    • Long-term follow up of patients with WHO grade 2 oligodendroglioma 

      Carstam, Louise; Latini, Francesco; Solheim, Ole Skeidsvoll; Bartek, Jiri; Pedersen, Lars Kjelsberg; Zetterling, Maria; Beniaminov, Stanislav; Sjåvik, Kristin; Ryttlefors, Mats; Jensdottir, Margret; Rydenhag, Bertil; Smits, Anja; Jakola, Asgeir Store (Peer reviewed; Journal article, 2023)
      Purpose Since the introduction of the molecular definition of oligodendrogliomas based on isocitrate dehydrogenase (IDH)-status and the 1p19q-codeletion, it has become increasingly evident how this glioma entity differs ...
    • Neurosurgical treatment and outcome patterns of meningioma in Sweden: a nationwide registry-based study 

      Corell, Alba; Thurin, Erik; Skoglund, Thomas; Farahmand, Dan; Henriksson, Roger; Rydenhag, Bertil; Gulati, Sasha; Bártek, Jiří; Jakola, Asgeir Store (Peer reviewed; Journal article, 2019)
      Background Surgery is the main treatment modality for intracranial meningiomas, but data on short-term surgical outcome are limited. The aim of this Swedish nationwide registry-based study was to benchmark the 30-day ...
    • Prognostic markers for survival in patients with oligodendroglial tumors; a single-institution review of 214 cases 

      Zetterling, Maria; Berhane, Luwane; Alafuzoff, Irina; Jakola, Asgeir Store; Smits, Anja (Peer reviewed; Journal article, 2017)
      Background: In the 2016 WHO classification, the diagnosis of oligodendroglioma has been restricted to IDH mutated, 1p19q codeleted tumors (IDHmut-codel). IDHmut oligoastrocytoma is now classified either as oligodendroglioma ...
    • Psychotropic and anti-epileptic drug use, before and after surgery, among patients with low-grade glioma: a nationwide matched cohort study 

      Rydén, Isabelle; Thurin, Erik; Carstam, Louise; Smits, Anja; Gulati, Sasha; Henriksson, Roger; Salvesen, Øyvind; Jakola, Asgeir Store (Journal article; Peer reviewed, 2021)
      Background: Low-grade glioma (LGG) is a relatively rare type of brain tumour. The use of antidepressant, sedative and anti-epileptic drugs can reflect the burden of the disease. While epilepsy is well-described in patients ...
    • Return to work following meningioma surgery: a Swedish nationwide registry-based matched cohort study 

      Thurin, Erik; Corell, Alba; Gulati, Sasha; Smits, Anja; Henriksson, Roger; Bartek, Jiri Jr.; Salvesen, Øyvind; Jakola, Asgeir Store (Peer reviewed; Journal article, 2020)
      Background Meningioma is the most common primary intracranial tumor. It is usually slow growing and benign, and surgery is the main treatment modality. There are limited data on return to work following meningioma ...
    • Risk of intracranial hemorrhage (RICH) in users of oral antithrombotic drugs: Nationwide pharmacoepidemiological study 

      Gulati, Sasha; Solheim, Ole; Carlsen, Sven Magnus; Øie, Lise Rystad; Jensberg, Heidi; Gulati, Agnete Malm; Madsbu, Mattis Aleksander; Giannadakis, Charalampis; Jakola, Asgeir Store; Salvesen, Øyvind (Journal article; Peer reviewed, 2018)
      Background The risks of intracranial haemorrhage (ICH) associated with antithrombotic drugs outside clinical trials are gaining increased attention. The aim of this nationwide study was to investigate the risk of ICH ...
    • Segmentation of glioblastomas in early post-operative multi-modal MRI with deep neural networks 

      Helland, Ragnhild Holden; Ferles, Alexandros; Pedersen, Andre; Kommers, Ivar; Ardon, Hilko; Barkhof, Frederik; Bello, Lorenzo; Berger, Mitchel S.; Dunås, Tora; Nibali, Marco Conti; Furtner, Julia; Hervey-Jumper, Shawn; Idema, Albert J. S.; Kiesel, Barbara; Tewari, Rishi Nandoe; Mandonnet, Emmanuel; Müller, Domenique M. J.; Robe, Pierre A.; Rossi, Marco; Sagberg, Lisa Millgård; Sciortino, Tommaso; Aalders, Tom; Wagemakers, Michiel; Widhalm, Georg; Witte, Marnix G.; Zwinderman, Aeilko H.; Majewska, Paulina Luiza; Jakola, Asgeir Store; Solheim, Ole Skeidsvoll; Hamer, Philip C. De Witt; Reinertsen, Ingerid; Eijgelaar, Roelant S.; Bouget, David Nicolas Jean-Marie (Peer reviewed; Journal article, 2023)
      Extent of resection after surgery is one of the main prognostic factors for patients diagnosed with glioblastoma. To achieve this, accurate segmentation and classification of residual tumor from post-operative MR images ...
    • Spinal cord compression in relation to clinical symptoms in patients with spinal meningiomas 

      Corell, Alba; Cerbach, Charlotte; Hoefling, Nickoleta; Björkman-Burtscher, Isabella M.; Jakola, Asgeir Store (Peer reviewed; Journal article, 2021)
      Objective: Spinal meningiomas are common primary tumors of the spinal canal and the resulting spinal cord compression (SCC) is intrinsically related to symptoms and outcome, but literature concerning this association is ...