• Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors 

      Olsen, Oddrun Elise; Hella, Hanne; Elsaadi, Samah; Jacobi, Carsten; Martinez-Hackert, Erik; Holien, Toril (Peer reviewed; Journal article, 2020)
      Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway. In some cases, activins also signal via the ...
    • Adherence to clinical guidelines for Barrett’s esophagus 

      Holmberg, Dag; Ness-Jensen, Eivind; Mattsson, Fredrik; Lagergren, Jesper (Journal article; Peer reviewed, 2019)
      Background and aim: Clinical guidelines recommend endoscopy surveillance at given intervals or endoscopic therapy for Barrett’s esophagus with low-grade dysplasia (LGD) and high-grade dysplasia (HGD). Whether these guidelines ...
    • Adiposity and risk of decline in glomerular filtration rate: Meta-analysis of individual participant data in a global consortium 

      Chang, Alex R.; Grams, Morgan E.; Ballew, Shoshana H.; Bilo, Henk; Correa, Adolfo; Evans, Marie; Gutierrez, Orlando M.; Hosseinpanah, Farhad; Iseki, Kunitoshi; Kenealy, Timothy; Klein, Barbara; Kronenberg, Florian; Lee, Brian J.; Li, Yuanying; Miura, Katsuyuki; Navaneethan, Sankar D.; Roderick, Paul J.; Valdivielso, Jose M.; Visseren, Frank L.J.; Zhang, Luxia; Gansevoort, Ron T.; Hallan, Stein; Levey, Andrew S.; Matsushita, Kunihiro; Shalev, Varda; Woodward, Mark (Journal article; Peer reviewed, 2019)
      Objective To evaluate the associations between adiposity measures (body mass index, waist circumference, and waist-to-height ratio) with decline in glomerular filtration rate (GFR) and with all cause mortality.Design ...
    • Admissions and surgery as indicators of hospital functions in Sierra Leone during the west-African Ebola outbreak 

      Bolkan, Håkon Angell; van Duinen, Aalke Johan; Samai, Mohammed; Bash-Taqi, Donald Alpha; Gassama, Ibarahim; Waalewijn, Bart; Wibe, Arne; von Schreeb, Johan (Journal article; Peer reviewed, 2018)
      Background In an attempt to assess the effects of the Ebola viral disease (EVD) on hospital functions in Sierra Leone, the aim of this study was to evaluate changes in provisions of surgery and non-Ebola admissions during ...
    • Adverse events of exercise therapy in randomised controlled trials: A systematic review and meta-analysis 

      Niemeijer, Andre; Lund, Hans; Stafne, Signe Nilssen; Ipsen, Thomas; Goldschmidt, Cathrine Luhaäär; Jørgensen, Claus Thomas; Juhl, Carsten B. (Journal article; Peer reviewed, 2019)
      Objective To evaluate the relative risk (RR) of serious and non-serious adverse events in patients treated with exercise therapy compared with those in a non-exercising control group. Design Systematic review and ...
    • Adverse events with fatal outcome associated with alemtuzumab treatment in multiple sclerosis 

      Holmøy, Trygve; Fevang, Børre; Olsen, David Benee; Spigset, Olav; Bø, Lars (Journal article; Peer reviewed, 2019)
      Objective Sporadic fatal adverse events have been reported during treatment of multiple sclerosis with alemtuzumab. To provide a systematic overview, we searched the centralized European Medicines Agency database of ...
    • Aerobic and cardiovascular autonomic adaptations to moderate intensity endurance exercise in patients with fibromyalgia 

      Bardal, Ellen Marie; Roeleveld, Karin; Mork, Paul Jarle (Journal article; Peer reviewed, 2015)
      Objective: To investigate whether moderate intensity endurance exercise has similar effects on cardiovascular fitness and autonomic function in patients with fibromyalgia and healthy controls. Design: Case-control ...
    • Age-of-onset information helps identify 76 genetic variants associated with allergic disease 

      Ferreira, Manuel A R; Vonk, Judith M.; Baurecht, Hansjörg; Marenholz, Ingo; Tian, Chao; Hoffman, Joshua D.; Helmer, Quinta; Tillander, Annika; Ullemar, Vilhelmina; Lu, Yi; Grosche, Sarah; Ruschendorf, Franz; Granell, Raquel; Brumpton, Ben Michael; Fritsche, Lars; Bhatta, Laxmi; Gabrielsen, Maiken Elvestad; Nielsen, Jonas Bille; Zhou, Wei; Hveem, Kristian; Langhammer, Arnulf; Holmen, Oddgeir; Løset, Mari; Abecasis, Goncalo; Willer, Cristen J.; Emami, Nima C.; Cavazos, Taylor B.; Witte, John S.; Szwajda, Agnieszka; 23andMe Research Team, ,; collaborators of SHARE study, ,; Hinds, David A.; Hubner, Norbert; Weidinger, Stephan; Magnusson, Patrik KE; Jorgenson, Eric; Karlsson, Robert; Paternoster, Lavinia; Boomsma, Dorret I.; Almqvist, Catarina; Lee, Young-Ae; Koppelman, Gerard H.; Esparza-Gordillo, Jorge; Hummel, Oliver; Hottenga, Jouke-Jan; Willemsen, Gonneke; Rodríguez, Elke; Hotze, Melanie; Franke, Andre; Matheson, Melanie C.; Dharmage, Shyamali Chandrika; Arnold, Andreas; Homuth, Georg; Schmidt, Carsten O; Thompson, Philip J.; Martin, Nicholas G; Duffy, David L.; Novak, Natalija; Schulz, Holger; Karrasch, Stefan; Gieger, Christian; Strauch, Konstantin; Melles, Ronald B (Peer reviewed; Journal article, 2020)
      Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which ...
    • Age-related change in peak oxygen uptake and change of cardiovascular risk factors. The HUNT Study 

      Letnes, Jon Magne; Dalen, Håvard; Aspenes, Stian Thoresen; Salvesen, Øyvind; Wisløff, Ulrik; Nes, Bjarne (Peer reviewed; Journal article, 2020)
      Background Large longitudinal studies on change in directly measured peak oxygen uptake (VO2peak) is lacking, and its significance for change of cardiovascular risk factors is uncertain. We aimed to assess ten-year ...
    • Aids to management of headache disorders in primary care (2nd edition): On behalf of the European Headache Federation and Lifting the Burden: The Global Campaign against Headache 

      Steiner, Timothy J.; Jensen, Rigmor Højland; Katsarava, Zaza; Linde, Mattias; MacGregor, E. Anne; Osipova, Vera; Paemeleire, Koen; Olesen, Jes; Peters, Michele; Martelletti, Paolo (Journal article; Peer reviewed, 2019)
      The Aids to Management are a product of the Global Campaign against Headache, a worldwide programme of action conducted in official relations with the World Health Organization. Developed in partnership with the European ...
    • Airway segmentation and centerline extraction from thoracic CT - Comparison of a new method to state of the art commercialized methods 

      Reynisson, Pall Jens; Scali, Marta; Smistad, Erik; Hofstad, Erlend Fagertun; Leira, Håkon Olav; Lindseth, Frank; Hernes, Toril A. Nagelhus; Amundsen, Tore; Sorger, Hanne; Langø, Thomas (Peer reviewed; Journal article, 2015)
      Introduction Our motivation is increased bronchoscopic diagnostic yield and optimized preparation, for navigated bronchoscopy. In navigated bronchoscopy, virtual 3D airway visualization is often used to guide a bronchoscopic ...
    • Allocentric representation in the human amygdala and ventral visual stream 

      Evensmoen, Hallvard Røe; Rimol, Lars Morten; Winkler, Anderson M.; Betzel, Richard; Hansen, Tor Ivar; Nili, Hamid; Håberg, Asta (Peer reviewed; Journal article, 2021)
      The hippocampus and the entorhinal cortex are considered the main brain structures for allocentric representation of the external environment. Here, we show that the amygdala and the ventral visual stream are involved in ...
    • An alternative approach to establishing unbiased colorectal cancer risk estimation in Lynch syndrome 

      Suerink, Manon; Rodriguez-Girondo, Mar; van der Klift, Heleen M.; Colas, Chrystelle; Brugieres, Laurence; Lavoine, Noémie; Jongmans, Marjolijn; Munar, Gabriel Capellá; Evans, D. Gareth; Farrell, Michael P.; Genuardi, Maurizio; Goldberg, Yael; Gomez-Garcia, Encarna; Heinimann, Karl; Hoell, Jessica I.; Aretz, Stefan; Jasperson, Kory W.; Kedar, Inbal; Modi, Mitul B.; Nikolaev, Sergey; van Os, Theo A.M.; Ripperger, Tim; Rueda, Daniel; Senter, Leigha; Sjursen, Wenche; Sunde, Lone; Therkildsen, Christina; Tibiletti, Maria G.; Trainer, Alison H.; Vos, Yvonne J.; Wagner, Anja; Winship, Ingrid; Wimmer, Katharina; Zimmermann, Stefanie Y.; Vasen, Hans F.; van Asperen, Christi J.; Houwing-Duistermaat, Jeanine J.; ten Broeke, Sanne W.; Nielsen, Maartje (Peer reviewed; Journal article, 2019)
      Purpose Biallelic pathogenic variants in the mismatch repair (MMR) genes cause a recessive childhood cancer predisposition syndrome known as constitutional mismatch repair deficiency (CMMRD). Family members with a ...
    • An in-hospital clinical care pathway with integrated decision support for cancer pain management reduced pain intensity and needs for hospital stay 

      Løhre, Erik Torbjørn; Thronæs, Morten; Brunelli, Cinzia; Kaasa, Stein; Klepstad, Pål (Journal article; Peer reviewed, 2019)
      Purpose A clinical care pathway for pain management in a palliative care unit was studied with outcomes related to patients, physicians, and health care service. Mandatory use of patient-reported outcome measures (PROMs) ...
    • Anbefalinger om bruk av rotavirusvaksine i Norge 

      Døllner, Henrik; Flem, elmira; Realfsen, Astrid; Rojahn, Astrid; Steenberg, Dianne; Sandbu, Synne; Vainio, Kirsti; Willbergh, Kine (rapport Nasjonalt folkehelseinstitutt;, Research report, 2013)
      Rotavirus smitter vanligvis ved nærkontakt og gir magesyke (gastroenteritt) som rammer praktisk talt alle barn i verden før de fyller fem år. Globalt er dette en viktig dødsårsak for spedbarn. I Norge er rotavirussykdom ...
    • Anesthesia for Cesarean Delivery: A Cross-Sectional Survey of Provincial, District, and Mission Hospitals in Zimbabwe 

      Lonnee, Herman; Madzimbamuto, Farai; Erlandsen, Ole RM; Vassenden, Astrid; Chikumba, Edson; Dimba, Rutendo; Myhre, Arne Kristian; Ray, Sunanda (Journal article; Peer reviewed, 2017)
      Abstract BACKGROUND: Cesarean delivery is the most common surgical procedure in low- and middle-income countries, so provision of anesthesia services can be measured in relation to it. This study aimed to assess the type ...
    • Animal models to study the role of long-term hypergastrinemia in gastric carcinogenesis 

      Fossmark, Reidar; Qvigstad, Gunnar; Martinsen, Tom Christian; Hauso, Øyvind; Waldum, Helge (Journal article; Peer reviewed, 2011)
      Patients with chronic hypergastrinemia due to chronic atrophic gastritis or gastrinomas have an increased risk of developing gastric malignancy, and it has been questioned whether also patients with hypergastrinemia caused ...
    • Animal study assessing safety of an acoustic coupling fluid that holds the potential to avoid surgically induced artifacts in 3D ultrasound guided operations 

      Jakola, Asgeir S; Jørgensen, Arve; Selbekk, Tormod; Michler, Ralf-Peter; Solheim, Ole; Torp, Sverre Helge; Sagberg, Lisa Millgård; Aadahl, Petter; Unsgård, Geirmund (Journal article; Peer reviewed, 2014)
      Background Use of ultrasound in brain tumor surgery is common. The difference in attenuation between brain and isotonic saline may cause artifacts that degrade the ultrasound images, potentially affecting resection grades ...
    • Antibiotic-loaded bone cement in prevention of periprosthetic joint infections in primary total knee arthroplasty: A register-based multicentre randomised controlled non-inferiority trial (ALBA trial) 

      Leta, Tesfaye Hordofa; Gjertsen, Jan-Erik; Dale, Håvard; Hallan, Geir; Lygre, Stein Håkon Låstad; Fenstad, Anne Marie; Dyrhovden, Gro Sævik; Westberg, Marianne; Wik, Tina Strømdal; Jakobsen, Rune Bruhn; Aamodt, Arild; Röhrl, Stephan Maximillian; Gøthesen, Øystein Johannes; Lindalen, Einar; Heir, Stig; Ludvigsen, Jarle; Bruun, Trond; Hansen, Ann Kristin; Aune, Knut Erik Moen; Warholm, Marianne; Skjetne, John Petter; Badawy, Mona; Høvding, Pål; Husby, Otto Schnell; Karlsen, Øystein Espeland; Furnes, Ove Nord (Peer reviewed; Journal article, 2021)
      Introduction The current evidence on the efficacy of antibiotic-loaded bone cement (ALBC) in reducing the risk of periprosthetic joint infections (PJI) after primary joint reconstruction is insufficient. In several European ...
    • Anxiety and depression in Nepal: Prevalence, comorbidity and associations 

      Risal, Ajay; Manandhar, Kedar; Linde, Mattias; Steiner, Timothy J.; Holen, Are (Peer reviewed; Journal article, 2016)
      Background Anxiety and depression are two important contributors to the global burden of disease. In many developing countries, including Nepal, their prevalences are yet to be assessed. Methods A nationwide ...