• Hypogammaglobulinemia and risk of exacerbation and mortality in patients with COPD 

      Holm, Are Martin; Andreassen, Siw Lillevik; Christensen, Vivi Lycke; Kongerud, Johny; Almås, Øystein; Auråen, Henrik; Henriksen, Anne Hildur; Aaberge, Ingeborg Aase S.; Klingenberg, Olav; Rustøen, Tone (Peer reviewed; Journal article, 2020)
      Introduction: Chronic obstructive pulmonary disease (COPD) may, in some patients, be characterized by recurring acute exacerbations. Often these exacerbations are associated with airway infections. As immunoglobulins (Ig) ...
    • Hypoxia imaging and theranostic potential of [64Cu][Cu(ATSM)] and ionic Cu(II) salts: a review of current evidence and discussion of the retention mechanisms 

      Liu, Tengzhi; Karlsen, Morten; Karlberg, Anna Maria; Redalen, Kathrine (Peer reviewed; Journal article, 2020)
      Background Tumor hypoxia (low tissue oxygenation) is an adverse condition of the solid tumor environment, associated with malignant progression, radiotherapy resistance, and poor prognosis. One method to detect tumor ...
    • Hysterektomi i Norge 2008–18 

      Johanson, Maja Lieng; Dögl, Malin Andrea Elisabeth; Lieng, Marit (Peer reviewed; Journal article, 2020)
      Background: Hysterectomy is a common gynaecological procedure. No Norwegian guidelines for the choice of hysterectomy surgical method exist, but international guidelines recommend minimally invasive surgery. The objective ...
    • Hysterotomy level at cesarean section and occurrence of large scar defects: a randomized single-blind trial 

      Vikhareva, Olga; Skott Rickle, G; Lavesson, T; Nedopekina, E; Brandell, K; Salvesen, Kjell Å (Peer reviewed; Journal article, 2019)
      Objective To study the association between the level of Cesarean hysterotomy and the presence of large uterine scar defects 6–9 months after delivery. Methods This was a two-center, randomized, single-blind trial of ...
    • Høysensitiv troponin I-måling ved koronarsuspekte brystsmerter i akuttmottak 

      Graven, Torbjørn; Klykken, Bjørnar E.; Kleinau, Jens Olaf; Skjetne, Kyrre; Andersen, Garrett Newton; Dalen, Håvard (Journal article; Peer reviewed, 2021)
      BAKGRUNN Formålet med studien var å evaluere en ny algoritme basert på analyser av høysensitiv troponin I for rask avklaring ved koronarsuspekte brystsmerter. MATERIALE OG METODE To tidsperioder – før (1.10.2016–31.12.2016) ...
    • Høyt nivå av lipoprotein(a) – utredning og behandling 

      Svilaas, Tone; Klemsdal, Tor Ole; Bogsrud, Martin Prøven; Græsdal, Asgeir; Vesterbekkmo, Elisabeth Kleivhaug; Asprusten, Emil Andreas; Langslet, Gisle; Retterstøl, Kjetil (Peer reviewed; Journal article, 2022)
      Omtrent 5 % av befolkningen har betydelig forhøyet verdi av lipoprotein(a) (Lp(a)), som er en arvelig betinget risikofaktor for hjerte- og karsykdom. Måling av lipoprotein(a) kan bedre kardiovaskulær risikostratifisering ...
    • ‘I want to get back!’ A qualitative study of long-term critically ill patients’ inner strength and willpower: Back home after long-term intensive care 

      Alexandersen, Ingeborg; Haugdahl, Hege Selnes; Stjern, Berit; Paulsby, Tove Engan; Lund, Stine Borgen; Haugan, Gørill (Peer reviewed; Journal article, 2021)
      Aims and objectives To provide insights into what promotes and challenges inner strength and willpower in formerly critically ill patients back home after a long-term ICU stay. Background Critically ill patients demand ...
    • Identification and Tracking of Antiviral Drug Combinations 

      Ianevski, Aleksandr; Yao, Rouan; Biza, Svetlana; Zusinaite, Eva; Mannik, Andres; Kivi, Gaily; Planken, Anu; Kurg, Kristiina; Tombak, Eva-Maria; Ustav, Mart Jr; Shtaida, Nastassia; Kulesskiy, Evgeny; Jo, Eunji; Yang, Jaewon; Lysvand, Hilde; Løseth, Kirsti; Oksenych, Valentyn; Aas, Per Arne; Tenson, Tanel; Vitkauskienė, Astra; Windisch, Marc P; Fenstad, Mona H.; Nordbø, Svein Arne; Ustav, Mart; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2020)
      Combination therapies have become a standard for the treatment for HIV and hepatitis C virus (HCV) infections. They are advantageous over monotherapies due to better efficacy, reduced toxicity, as well as the ability to ...
    • Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant 

      Wang, Qiang; Martínez-Bonet, Marta; Kim, Taehyeung; Sparks, Jeffrey A.; Ishigaki, Kazuyoshi; Chen, Xiaoting; Sudman, Marc; Aguiar, Vitor; Sim, Sangwan; Hernandez, Marcos Chiñas; Chiu, Darren J.; Wactor, Alexandra; Wauford, Brian; Marion, Miranda C.; Gutierrez-Arcelus, Maria; Bowes, John; Eyre, Stephen; Nordal, Ellen Berit; Prahalad, Sampath; Rygg, Marite; Videm, Vibeke; Raychaudhuri, Soumya; Weirauch, Matthew T.; Langefeld, Carl D.; Thompson, Susan D.; Nigrovic, Peter A. (Peer reviewed; Journal article, 2023)
      TRAF1/C5 was among the first loci shown to confer risk for inflammatory arthritis in the absence of an associated coding variant, but its genetic mechanism remains undefined. Using Immunochip data from 3,939 patients with ...
    • Identification of exercise-regulated genes in mice exposed to cigarette smoke 

      Aakerøy, Lars; Cheng, Chew W.; Sustova, Pavla; Scrimgeour, Nathan Robert; Wahl, Sissel Gyrid Freim; Steinshamn, Sigurd Loe; Bowen, T Scott; Brønstad, Eivind (Peer reviewed; Journal article, 2022)
      Cigarette smoke (CS) is the major risk factor for COPD and is linked to cardiopulmonary dysfunction. Exercise training as part of pulmonary rehabilitation is recommended for all COPD patients. It has several physiological ...
    • Identification of gait domains and key gait variables following hip fracture 

      Thingstad, Pernille; Egerton, Thorlene; Ihlen, Espen Alexander F.; Taraldsen, Kristin; Moe-Nilssen, Rolf; Helbostad, Jorunn L. (Peer reviewed; Journal article, 2015)
      Background:Restoration of gait is an important goal of rehabilitation after hip fracture. Numerous spatial andtemporal gait variables have been reported in the literature, but beyond gait speed, there is little agreement ...
    • Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients 

      Colombo, Francesca; Pintarelli, Giulia; Galvan, Antonella; Noci, Sara; Corli, Oscar; Skorpen, Frank; Klepstad, Pål; Kaasa, Stein; Pigni, Alessandra; Brunelli, Cinzia; Roberto, Anna; Piazza, Rocco; Pirola, Alessandra; Gambacorti-Passerini, Carlo; Caraceni, Augusto Tomasso Giovanni (Peer reviewed; Journal article, 2020)
      Nausea and vomiting are often associated with opioid analgesia in cancer patients; however, only a subset of patients develop such side effects. Here, we tested the hypothesis that the occurrence of nausea and vomiting is ...
    • Identification of metastasis-associated metabolic profiles in tumors using 1H-HR-MAS-MRS 

      Gorad, Saurabh Sayajirao; Ellingsen, Christine; Bathen, Tone Frost; Mathiesen, Berit Synnøve; Moestue, Siver Andreas; Rofstad, Einar K (Journal article; Peer reviewed, 2015)
      Tumors develop an abnormal microenvironment during growth, and similar to the metastatic phenotype, the metabolic phenotype of cancer cells is tightly linked to characteristics of the tumor microenvironment (TME). In this ...
    • Identification of metastasis-associated microRNAs in serum from rectal cancer patients 

      Mjelle, Robin; Sellæg, Kjersti; Sætrom, Pål; Thommesen, Liv; Sjursen, Wenche; Hofsli, Eva (Peer reviewed; Journal article, 2017)
      MicroRNAs (miRNAs) are promising prognostic and diagnostic biomarkers due to their high stability in blood. Here we investigate the expression of miRNAs and other noncoding (nc) RNAs in serum of rectal cancer patients. ...
    • Identification of novel cyanoacrylate monomers for use in nanoparticle drug delivery systems prepared by miniemulsion polymerisation – A multistep screening approach 

      Hyldbakk, Astrid; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Åslund, Andreas; Klinkenberg, Geir; Nakstad, Vu; Wågbø, Ane Marit; Schmid, Ruth Baumberger; Molesworth, Peter Patrick (Peer reviewed; Journal article, 2022)
      Poly (alkyl cyanoacrylate) (PACA) polymeric nanoparticles (NPs) are promising drug carriers in drug delivery. However, the selection of commercially available alkyl cyanoacrylate (ACA) monomers is limited, because most ...
    • Identification of novel genetic variants associated with cardiorespiratory fitness 

      Bye, Anja; Klevjer, Marie; Ryeng, Einar; Silva, Gustavo Jose Justo; Moreira, Jose Bianco Nascimento; Stensvold, Dorthe; Wisløff, Ulrik (Peer reviewed; Journal article, 2020)
      Introduction Low maximal oxygen uptake (VO2max) is a strong and independent risk factor for all-cause and cardiovascular disease (CVD) mortality. For other CVD risk factors, numerous genetic association studies have been ...
    • Identification of the source of elevated hepatocyte growth factor levels in multiple myeloma patients 

      Rampa, Christoph Samuel; Tian, Erming; Våtsveen, Thea Kristin; Buene, Glenn; Slørdahl, Tobias Schmidt; Børset, Magne; Waage, Anders; Sundan, Anders (Journal article; Peer reviewed, 2014)
      Background Hepatocyte growth factor (HGF) is a pleiotropic cytokine which can lead to cancer cell proliferation, migration and metastasis. In multiple myeloma (MM) patients it is an abundant component of the bone marrow. ...
    • Identification of unhealthy alcohol use by self-report and phosphatidylethanol (PEth) blood concentrations in an acute psychiatric department 

      Finanger, Trine; Vaaler, Arne; Spigset, Olav; Aamo, Trond Oskar; Andreassen, Trine Naalsund; Gråwe, Rolf W.; Skråstad, Ragnhild Bergene (Peer reviewed; Journal article, 2022)
      Background The use of standard screening methods could improve the detection rate of unhealthy alcohol use in patients admitted to psychiatric acute and emergency departments. The aim of the present study was to investigate ...
    • Identifying possible biomarkers of lower urinary tract symptoms using metabolomics and partial least square regression 

      Hopland-Nechita, Florin Vasile; Andersen, John Roger; Rajalahti, Tarja; Andreassen, Trygve; Beisland, Christian (Peer reviewed; Journal article, 2023)
      Introduction The objective of this study was to explore potential novel biomarkers for moderate to severe lower urinary tract symptoms (LUTS) using a metabolomics-based approach, and statistical methods with significant ...
    • IFN-α with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia 

      Huuhtanen, Jani; Ilander, Mette; Yadav, Bhagwan; Dufva, Olli M.J.; Lähteenmäki, Hanna; Kasanen, Tiina; Klievink, Jay; Olsson-Strömberg, Ulla; Stentoft, Jesper; Richter, Johan; Koskenvesa, Perttu; Höglund, Martin; Söderlund, Stina; Dreimane, Arta; Porkka, Kimmo; Gedde-Dahl, Tobias; Gjertsen, Bjørn Tore; Stenke, Leif; Myhr-Eriksson, Kristina; Markevärn, Berit; Lübking, Anna; Dimitrijevic, Andreja; Udby, Lene; Bjerrum, Ole Weis; Hjorth-Hansen, Henrik; Mustjoki, Satu (Peer reviewed; Journal article, 2022)
      In chronic myeloid leukemia (CML), combination therapies with tyrosine kinase inhibitors (TKIs) aim to improve the achievement of deep molecular remission that would allow therapy discontinuation. IFN-α is one promising ...