Blar i Publikasjoner fra Cristin - St. Olavs hospital på forfatter "Damås, Jan Kristian"
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Association of Genetically Predicted Insomnia with Risk of Sepsis: A Mendelian Randomization Study
Thorkildsen, Marianne Thorkildsen; Gustad, Lise Tuset; Mohus, Randi Marie; Burgess, Stephen; Nilsen, Tom Ivar Lund; Damås, Jan Kristian; Rogne, Tormod (Peer reviewed; Journal article, 2023)Importance Insomnia has been associated with altered inflammatory response as well as increased risk of infections and sepsis in observational studies. However, these studies are prone to bias, such as residual confounding. ... -
Direct and indirect effects of socioeconomic status on sepsis risk and mortality: a mediation analysis of the HUNT Study
Stensrud, Vilde; Gustad, Lise Tuset; Damås, Jan Kristian; Solligård, Erik; Krokstad, Steinar; Nilsen, Tom Ivar Lund (Peer reviewed; Journal article, 2023)Background Socioeconomic status (SES) may influence risk of sepsis and sepsis-related mortality, but to what extent lifestyle and health-related factors mediate this effect is not known. Methods The study included 65 227 ... -
Epidemiological and clinical characteristics of immunocompromised patients infected with Pneumocystis jirovecii in a twelve-year retrospective study from Norway
Grønseth, Stine; Rogne, Tormod; Hannula, Raisa; Åsvold, Bjørn Olav; Afset, Jan Egil; Damås, Jan Kristian (Journal article; Peer reviewed, 2021) -
High levels of discordant antimicrobial therapy in hospital-acquired bloodstream infections is associated with increased mortality in an intensive care, low antimicrobial resistance setting
Waagsbø, Bjørn; Stuve, Nora; Afset, Jan Egil; Klepstad, Pål; Mo, Skule; Heggelund, Lars; Damås, Jan Kristian (Peer reviewed; Journal article, 2022)Background Bloodstream infections (BSI) occur frequently and are associated with severe outcomes. In this study we aimed to investigate proportions of patients that received discordant empirical antimicrobial therapy and ... -
The inflammatory response is related to circulatory failure after out-of-hospital cardiac arrest: A prospective cohort study
Langeland, Halvor Johannes Breivik; Damås, Jan Kristian; Mollnes, Tom Eirik; Ludviksen, Judith K; Ueland, Thor; Michelsen, Annika Elisabet; Løberg, Magnus; Bergum, Daniel; Nordseth, Trond; Skjærvold, Nils Kristian; Klepstad, Pål (Peer reviewed; Journal article, 2021)Background: Whole body ischemia and reperfusion injury after cardiac arrest leads to the massive inflammation clinically manifested in the post-cardiac arrest syndrome. Previous studies on the inflammatory effect on ... -
Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial
Huse, Camilla; Anstensrud, Anne Kristine; Michelsen, Annika Elisabet; Ueland, Thor; Broch, Kaspar; Woxholt, Sindre; Yang, Kuan; Sharma, Kapil Kishore; Tøllefsen, Ingvild Maria; Bendz, Bjørn; Amundsen, Brage H.; Damås, Jan Kristian; Berg, Erlend Sturle; Bjørkelund, Elisabeth; Quiles-Jiménez, Ana M T; Bjerkeli, Vigdis; Bendz, Christina; Kleveland, Ola; Stensæth, Knut Haakon; Opdahl, Anders; Kløw, Nils-Einar; Andersen, Geir Øystein; Wiseth, Rune; Halvorsen, Bente; Gullestad, Lars; Seljeflot, Ingebjørg; Aukrust, Pål; Osnes, Liv T. N.; Dahl, Tuva Børresdatter (Peer reviewed; Journal article, 2022)We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves myocardial salvage in ST-elevation myocardial infarction (STEMI). However, the mechanisms for this effect are not clear. Methods In this ... -
Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction
Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Yndestad, Arne; Broch, Kaspar; Holte, Espen; Ryan, Liv; Amundsen, Brage H.; Bendz, Bjørn; Aakhus, Svend; Espevik, Terje; Halvorsen, Bente; Mollnes, Tom Eirik; Wiseth, Rune; Gullestad, Lars; Aukrust, Pål; Damås, Jan Kristian (Journal article; Peer reviewed, 2018)Aim To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network in patients with acute non-ST-elevation myocardial infarction (NSTEMI). Methods 117 patients with acute NSTEMI were randomised ... -
Kodepraksis ved sepsis 2008–21
Skei, Nina Vibeche; Afset, Jan Egil; Ehrnström, Anna Greta Birgitta; Nessan, Bente Sofie; Damås, Jan Kristian; Nilsen, Tom Ivar Lund; Gustad, Lise Tuset (Journal article; Peer reviewed, 2024)Bakgrunn:Sepsis har høy insidens og mortalitet. For planlegging av helsetjenester og i forskning trengs presise data, og det er behov for å kartlegge kodepraksis i Norge. Materiale og metode: Alle personer over 17 år som ... -
Mycotic abdominal aortic aneurysm caused by Borrelia afzelii: a case report
Torsteinsen, Magne; Nilsen, Hans-Johnny; Damås, Jan Kristian; Stensvåg, Dordi; Nyrønning, Linn Ålstedt; Bergh, Kåre (Peer reviewed; Journal article, 2022)Background Inflammatory aneurysms and mycotic aneurysms make up a minority of abdominal aortic aneurysms. Mainly autoimmune mechanisms are proposed in the pathogenesis of inflammatory aneurysms, and it is not routine ... -
Predicting In-Hospital Death from Derived EHR Trajectory Features
Bopche, Rajeev; Gustad, Lise Tuset; Afset, Jan Egil; Damås, Jan Kristian; Nytrø, Øystein (Chapter, 2024)Medical histories of patients can provide insight into the immediate future of a patient. While most studies propose to predict survival from vital signs and hospital tests within one episode of care, we carry out selective ... -
Semiquantitative Real-Time PCR to Distinguish Pneumocystis Pneumonia from Colonization in a Heterogeneous Population of HIV-Negative Immunocompromised Patients
Grønseth, Stine; Rogne, Tormod; Hannula, Raisa; Åsvold, Bjørn Olav; Afset, Jan Egil; Damås, Jan Kristian (Peer reviewed; Journal article, 2021)Pneumocystis jirovecii is a threat to iatrogenically immunosuppressed individuals, a heterogeneous population at rapid growth. We assessed the ability of an in-house semiquantitative real-time PCR assay to discriminate ... -
Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction
Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Holven, Kirsten Bjørklund; Aukrust, Pål; Gullestad, Lars; Yndestad, Arne; Halvorsen, Bente (Journal article; Peer reviewed, 2018)Background The IL-6 receptor antagonist tocilizumab has been shown to attenuate the proatherogenic lipoprotein a [Lp(a)] in rheumatoid arthritis. We evaluated if a single dose of tocilizumab reduced Lp(a) in patients with ... -
Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction
Helseth, Ragnhild; Kleveland, Ola; Ueland, Thor; Wiseth, Rune; Damås, Jan Kristian; Broch, Kaspar; Michelsen, Annika Elisabet; Bendz, Bjørn; Gullestad, Lars; Aukrust, Pål; Seljeflot, Ingebjørg (Peer reviewed; Journal article, 2021)Objective Beyond reducing inflammation and troponin T (TnT) release, the interleukin-6 receptor antagonist tocilizumab reduces neutrophil counts in patients with non-ST segment elevation myocardial infarction (NSTEMI). It ... -
Trends in mortality after a sepsis hospitalization: a nationwide prospective registry study from 2008 to 2021
Skei, Nina Vibeche; Nilsen, Tom Ivar Lund; Mohus, Randi Marie; Prescott, Hallie C.; Lydersen, Stian; Solligård, Erik; Damås, Jan Kristian; Gustad, Lise Tuset (Peer reviewed; Journal article, 2023)Background Few studies have reported on mortality beyond one year after sepsis. We aim to describe trends in short- and long-term mortality among patients admitted with sepsis, and to describe the association between ... -
Use of peripheral venous catheters in two Norwegian hospitals.
Høvik, Lise Husby; Gjeilo, Kari Hanne; Lydersen, Stian; Solligård, Erik; Damås, Jan Kristian; Gustad, Lise Tuset (Peer reviewed; Journal article, 2020)BAKGRUNN De fleste pasienter ved norske sykehus får rutinemessig ett eller flere perifere venekatetre. Et perifert venekateter regnes som ufarlig, men kan gi lokal infeksjon, med blodstrømsinfeksjon og sepsis som følge. ... -
Variation in serum PCSK9 (proprotein convertase subtilisin/kexin type 9), cardiovascular disease risk, and an investigation of potential unanticipated effects of PCSK9 inhibition
Brumpton, Ben Michael; Fritsche, Lars; Zheng, Jie; Nielsen, Jonas Bille; Mannila, Maria Nastase; Surakka, Ida; Rasheed, Humaira; Vie, Gunnhild Åberge; Graham, Sarah E.; Gabrielsen, Maiken Elvestad; Laugsand, Lars Erik; Aukrust, Pål; Vatten, Lars Johan; Damås, Jan Kristian; Ueland, Thor; Janszky, Imre; Zwart, John-Anker; van't Hooft, Ferdinand M.; Seidah, Nabil Georges; Hveem, Kristian; Willer, Cristen; Smith, George Davey; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2019)PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors reduce serum LDL (low-density lipoprotein) cholesterol (LDL-C) by increasing uptake in the liver. Although some long-term trials have evaluated their safety, ...