Browsing Publikasjoner fra Cristin - St. Olavs hospital by Title
Now showing items 853-872 of 1657
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Intraperitoneal administration of cabazitaxel-loaded nanoparticles in peritoneal metastasis models
(Peer reviewed; Journal article, 2023)Colorectal and ovarian cancers frequently develop peritoneal metastases with few treatment options. Intraperitoneal chemotherapy has shown promising therapeutic effects, but is limited by rapid drug clearance and systemic ... -
Intratumor DNA methylation heterogeneity in glioblastoma: Implications for DNA methylation-based classification
(Peer reviewed; Journal article, 2019)Background. A feature of glioblastoma (GBM) is cellular and molecular heterogeneity, both within and between tumors. This variability causes a risk for sampling bias and potential tumor escape from future targeted therapy. ... -
Intraventricular Vector Flow Imaging with Blood Speckle Tracking in Adults: Feasibility, Normal Physiology and Mechanisms in Healthy Volunteers
(Peer reviewed; Journal article, 2021)This study examines the feasibility of blood speckle tracking for vector flow imaging in healthy adults and describes the physiologic flow pattern and vortex formation in relation to the wall motion in the left ventricle. ... -
Introducing fairness in Norwegian air ambulance base location planning
(Peer reviewed; Journal article, 2021)Background A primary task of the Norwegian helicopter emergency medical services (HEMS) is to provide advanced medical care to the critical ill and injured outside of hospitals. Where HEMS bases are located, directly ... -
Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health
(Peer reviewed; Journal article, 2021)Observational epidemiological studies have reported that higher maternal blood pressure (BP) during pregnancy is associated with increased future risk of offspring cardiometabolic disease. However, it is unclear whether ... -
Investigating causal relations between sleep traits and risk of breast cancer in women: Mendelian randomisation study
(Peer reviewed; Journal article, 2019)Objective To examine whether sleep traits have a causal effect on risk of breast cancer. Design Mendelian randomisation study. Setting UK Biobank prospective cohort study and Breast Cancer Association Consortium ... -
Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study
(Peer reviewed; Journal article, 2021)Background Sedentary behaviour is associated with disease, but the molecular mechanisms are not understood. Valid biomarkers with predictive and explanatory properties are required. Therefore, we have investigated traditional ... -
Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial
(Peer reviewed; Journal article, 2019)Aims To compare outcomes of glucagon‐stimulated C‐peptide tests (GSCTs) in people with latent autoimmune diabetes in adults (LADA) after a 21‐month intervention with either insulin or the dipeptidyl peptidase‐4 inhibitor ... -
Investigating the causal interplay between sleep traits and risk of acute myocardial infarction: a Mendelian randomization study
(Peer reviewed; Journal article, 2023)Background Few studies have investigated the joint effects of sleep traits on the risk of acute myocardial infarction (AMI). No previous study has used factorial Mendelian randomization (MR) which may reduce confounding, ... -
Investigating the effect of sex and ketosis on weight-loss-induced changes in appetite
(Peer reviewed; Journal article, 2019)Background Diet-induced weight loss (WL) is usually accompanied by increased appetite, a response that seems to be absent when ketogenic diets are used. It remains unknown if sex modulates the appetite suppressant effect ... -
Iodine status and determinants in adults in Norway – results from a population-based health examination survey (The HUNT Study)
(Journal article; Peer reviewed, 2024)Background: In Norway, there is a lack of knowledge about the iodine status in the general and older adult population, and there is no established national monitoring programme for iodine. Several studies have indicated ... -
Irisin reduces orthodontic tooth movement in rats by promoting the osteogenic potential in the periodontal ligament
(Peer reviewed; Journal article, 2023)Objectives Positive effects of irisin on osteogenic differentiation of periodontal ligament (PDL) cells have been identified previously, this study aims to examine its effect on orthodontic tooth movement (OTM) in ... -
Is long-bout sedentary behaviour associated with long-Term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study
(Peer reviewed; Journal article, 2020)Background and purpose Sedentary behaviour is a risk factor for vascular disease and stroke patients are more sedentary than their age-matched peers. The association with glucose levels, as a potential mediator, is unclear, ... -
Is pituitary MRI screening necessary in cluster headache?
(Peer reviewed; Journal article, 2021)Objective To determine the prevalence and clinical predictors of pituitary adenomas in cluster headache patients, in order to determine the necessity of performing dedicated pituitary magnetic resonance imaging in patients ... -
Is police investigation of rape biased by characteristics of victims?
(Peer reviewed; Journal article, 2020)Aim To explore differences in police investigations between cases of rape against women with and without vulnerability factors. Methods Retrospective, descriptive study of cases of rape against women ≥16 years of age. ... -
Is the anatomical distribution of low-grade gliomas linked to regions of gliogenesis?
(Peer reviewed; Journal article, 2020)Introduction According to the stem cell theory, two neurogenic niches in the adult human brain may harbor cells that initiate the formation of gliomas: The larger subventricular zone (SVZ) and the subgranular zone (SGZ) ... -
Is there a causal relationship between stress and migraine? Current evidence and implications for management
(Peer reviewed; Journal article, 2021)Background The purpose of this narrative review is to examine the literature investigating a causal relationship between stress and migraine and evaluate its implications for managing migraine. Methods PubMed, PsycINFO and ... -
Is there a genetic cause of appetite loss? - An explorative study in 1853 cancer patients
(Journal article; Peer reviewed, 2012)Background Appetite loss has a major impact on cancer patients. It is exceedingly prevalent, is a prognostic indicator and is associated with inferior quality of life. Cachexia is a multi‐factorial syndrome defined by a ... -
Is there a relationship between the stratum corneum thickness and that of the viable parts of tumour cells in basal cell carcinoma?
(Journal article; Peer reviewed, 2016)Basal cell carcinoma (BCC) is an invasive epithelial skin tumour. The thickness of the outermost epidermal layer of the skin, the stratum corneum (SC), influences drug uptake and penetration into tumour and may thereby ... -
Is there a U-shaped relationship between physical activity in leisure time and risk of chronic low back pain? A follow-up in the HUNT Study
(Journal article; Peer reviewed, 2016)Background Physical activity in leisure time is often considered to have favourable effects on the risk of low back pain (LBP), but demonstrating a definite association in epidemiological studies has proven difficult. The ...