Blar i Publikasjoner fra Cristin - St. Olavs hospital på tittel

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    • Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease 

      Egiazarian, Milena Armenovna; Strømstad, Silje; Sakshaug, Teri; Nunez-Nescolarde, Ana; Bethge, Nicole; Bjørås, Magnar; Scheffler, Katja (Peer reviewed; Journal article, 2022)
      Oxidative stress generating DNA damage has been shown to be a key characteristic in Alzheimer's disease (AD). However, how it affects the pathogenesis of AD is not yet fully understood. Neil3 is a DNA glycosylase initiating ...

    • Age-of-onset information helps identify 76 genetic variants associated with allergic disease 

      Ferreira, Manuel A R; Vonk, Judith M.; Baurecht, Hansjörg; Marenholz, Ingo; Tian, Chao; Hoffman, Joshua D.; Helmer, Quinta; Tillander, Annika; Ullemar, Vilhelmina; Lu, Yi; Grosche, Sarah; Ruschendorf, Franz; Granell, Raquel; Brumpton, Ben Michael; Fritsche, Lars; Bhatta, Laxmi; Gabrielsen, Maiken Elvestad; Nielsen, Jonas Bille; Zhou, Wei; Hveem, Kristian; Langhammer, Arnulf; Holmen, Oddgeir; Løset, Mari; Abecasis, Goncalo; Willer, Cristen J.; Emami, Nima C.; Cavazos, Taylor B.; Witte, John S.; Szwajda, Agnieszka; 23andMe Research Team, ,; collaborators of SHARE study, ,; Hinds, David A.; Hubner, Norbert; Weidinger, Stephan; Magnusson, Patrik KE; Jorgenson, Eric; Karlsson, Robert; Paternoster, Lavinia; Boomsma, Dorret I.; Almqvist, Catarina; Lee, Young-Ae; Koppelman, Gerard H.; Esparza-Gordillo, Jorge; Hummel, Oliver; Hottenga, Jouke-Jan; Willemsen, Gonneke; Rodríguez, Elke; Hotze, Melanie; Franke, Andre; Matheson, Melanie C.; Dharmage, Shyamali Chandrika; Arnold, Andreas; Homuth, Georg; Schmidt, Carsten O; Thompson, Philip J.; Martin, Nicholas G; Duffy, David L.; Novak, Natalija; Schulz, Holger; Karrasch, Stefan; Gieger, Christian; Strauch, Konstantin; Melles, Ronald B (Peer reviewed; Journal article, 2020)
      Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which ...

    • AI-driven attenuation correction for brain PET/MRI: Clinical evaluation of a dementia cohort and importance of the training group size 

      Ladefoged, Claes Nøhr; Hansen, Adam Espe; Henriksen, Otto Mølby; Bruun, Frederik Jager; Eikenes, Live; Øen, Silje Kjærnes; Karlberg, Anna Maria; Højgaard, Liselotte; Law, Ian; Andersen, Flemming Littrup (Peer reviewed; Journal article, 2020)
      Introduction Robust and reliable attenuation correction (AC) is a prerequisite for accurate quantification of activity concentration. In combined PET/MRI, AC is challenged by the lack of bone signal in the MRI from which ...

    • Aids to management of headache disorders in primary care (2nd edition): On behalf of the European Headache Federation and Lifting the Burden: The Global Campaign against Headache 

      Steiner, Timothy J.; Jensen, Rigmor Højland; Katsarava, Zaza; Linde, Mattias; MacGregor, E. Anne; Osipova, Vera; Paemeleire, Koen; Olesen, Jes; Peters, Michele; Martelletti, Paolo (Journal article; Peer reviewed, 2019)
      The Aids to Management are a product of the Global Campaign against Headache, a worldwide programme of action conducted in official relations with the World Health Organization. Developed in partnership with the European ...

    • Akutt lungesviktsyndrom hos covid-19-pasient med negative nasofarynksprøver 

      Hauge, Marit Teigen; Nilsen, Einar; Nordseth, Trond (Peer reviewed; Journal article, 2020)
      En kvinne i 40-årene som ble innlagt etter tre ukers sykehistorie med luftveisinfeksjon, utviklet alvorlig akutt lungesviktsyndrom. Nasofarynksprøver tatt dag 1 og 3 etter innleggelse var negative for sars-CoV-2-viruset, ...

    • Akutte laparotomier ved St. Olavs hospital 

      Wangen, Endre; Gillund, Even Westgaard; Reinholdtsen, Eirik Midtgaard; Henriksveen, Kristian Jostad; van Duinen, Aalke Johan; Faqiri, Mirwais; Ystgaard, Brynjulf; Bolkan, Håkon Angell (Peer reviewed; Journal article, 2023)
      BAKGRUNN Akutte laparotomier er assosiert med høyere mortalitet og lengre sykehusopphold enn elektive laparotomier. Formålet med denne studien var å kartlegge pasientkarakteristika, sykehusforløp og mortalitet for dem som ...

    • Alendronate and omeprazole in combination reduce angiogenic and growth signals from osteoblasts 

      Kruger, Tormod Bjartveit; Herlofson, Bente Brokstad; Lian, Aina-Mari; Syversen, Unni; Reseland, Janne Elin (Peer reviewed; Journal article, 2021)
      Objective: Due to gastrointestinal side effects of oral bisphosphonates (BPs), proton pump inhibitors (PPIs) are often prescribed. PPIs may enhance the risk of osteonecrosis of the jaw, a rare side effect of BPs. Therefore, ...

    • ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA 

      Wollen, Kristian Lied; Hagen, Lars; Vågbø, Cathrine Broberg; Rabe, Renana; Iveland, Tobias Solli; Aas, Per Arne; Sharma, Animesh; Sporsheim, Bjørnar; Erlandsen, Hilde O.; Palibrk, Vuk; Bjørås, Magnar; Fonseca, Davi de Miranda; Mosammaparast, Nima; Slupphaug, Geir (Peer reviewed; Journal article, 2021)
      Background: Reversible enzymatic methylation of mammalian mRNA is widespread and serves crucial regulatory functions, but little is known to what degree chemical alkylators mediate overlapping modifcations and whether cells ...

    • An alternative approach to establishing unbiased colorectal cancer risk estimation in Lynch syndrome 

      Suerink, Manon; Rodriguez-Girondo, Mar; van der Klift, Heleen M.; Colas, Chrystelle; Brugieres, Laurence; Lavoine, Noémie; Jongmans, Marjolijn; Munar, Gabriel Capellá; Evans, D. Gareth; Farrell, Michael P.; Genuardi, Maurizio; Goldberg, Yael; Gomez-Garcia, Encarna; Heinimann, Karl; Hoell, Jessica I.; Aretz, Stefan; Jasperson, Kory W.; Kedar, Inbal; Modi, Mitul B.; Nikolaev, Sergey; van Os, Theo A.M.; Ripperger, Tim; Rueda, Daniel; Senter, Leigha; Sjursen, Wenche; Sunde, Lone; Therkildsen, Christina; Tibiletti, Maria G.; Trainer, Alison H.; Vos, Yvonne J.; Wagner, Anja; Winship, Ingrid; Wimmer, Katharina; Zimmermann, Stefanie Y.; Vasen, Hans F.; van Asperen, Christi J.; Houwing-Duistermaat, Jeanine J.; ten Broeke, Sanne W.; Nielsen, Maartje (Peer reviewed; Journal article, 2019)
      Purpose Biallelic pathogenic variants in the mismatch repair (MMR) genes cause a recessive childhood cancer predisposition syndrome known as constitutional mismatch repair deficiency (CMMRD). Family members with a ...

    • Amongst Norwegian paediatricians there is little agreement in management of cases of suspected child maltreatment 

      Vollmer-Sandholm, Mary Jo; Myhre, Arne Kristian; Otterman, Gabriel; Lydersen, Stian; Stray-Pedersen, Arne (Peer reviewed; Journal article, 2021)
      Aim Child maltreatment is not unusual in our society but little is known about the medical management of cases in the Nordic countries. This study investigated physician knowledge and practice in cases of suspected physical ...

    • Amoxicillin did not Reduce Modic Change Oedema in Patients with Chronic Low Back pain - subgroup Analyses of a Randomised Trial (the AIM study) 

      Kristoffersen, Per Martin; Vetti, Nils; Grøvle, Lars; Brox, Jens Ivar; Bråten, Lars Christian Haugli; Grotle, Margreth; Haugen, Anne Julsrud; Rolfsen, Mads Peder; Froholdt, Anne; Skouen, Jan Sture; Lutro, Olav; Marchand, Gunn Hege; Anke, Audny Gabriele Wagner; Zwart, John Anker Henrik; Storheim, Kjersti; Assmus, Jörg; Espeland, Ansgar (Peer reviewed; Journal article, 2022)
      Study Design - Exploratory subgroup analyses of a randomised trial [Antibiotics in Modic changes (AIM) study]. Objective - The aim was to assess the effect of amoxicillin versus placebo in reducing Modic change (MC) edema ...

    • Amsterdam Complex Pelvic Pain Symptom Scale with subscales: Based on a Norwegian translation, psychometric assessment and modification of the Amsterdam Hyperactive Pelvic Floor scale 

      Saga, Susan; Stafne, Signe Nilssen; Dons, Vilde; Bratlie, Ingvild; Spetalen, Siri; Hagemann, Cecilie Therese (Peer reviewed; Journal article, 2023)
      Introduction Women with an abnormally high pelvic floor muscle tone may have a clinical presentation that is complex, involving urinary, anorectal and/or sexual dysfunction, genital/pelvic pain and psychological distress. ...

    • An in-hospital clinical care pathway with integrated decision support for cancer pain management reduced pain intensity and needs for hospital stay 

      Løhre, Erik Torbjørn; Thronæs, Morten; Brunelli, Cinzia; Kaasa, Stein; Klepstad, Pål (Journal article; Peer reviewed, 2019)
      Purpose A clinical care pathway for pain management in a palliative care unit was studied with outcomes related to patients, physicians, and health care service. Mandatory use of patient-reported outcome measures (PROMs) ...

    • Analyses of Increased Mortality in New and Known Diabetes in Patients with Coronary Disease Enrolled in the NORSTENT Randomized Study 

      Mølstad, Per; Nordrehaug, Jan Erik; Steigen, Terje; Wilsgaard, Tom; Wiseth, Rune; Bønaa, Kaare Harald (Peer reviewed; Journal article, 2021)
      Background: NORSTENT trial randomized 9,013 patients to percutaneous coronary intervention with drug-eluting stents (DES) or bare-metal stents (BMS) with a 5-year follow-up. Among the patients, 5,512 had measured either ...

    • Anatomical variations in the circle of Willis are associated with increased odds of intracranial aneurysms: The Tromsø study 

      Hindenes, Lars Bakke; Ingebrigtsen, Tor; Isaksen, Jørgen Gjernes; Håberg, Asta; Johnsen, Liv-Hege; Herder, Marit; Mathiesen, Ellisiv B.; Vangberg, Torgil Riise (Peer reviewed; Journal article, 2023)
      Purpose Studies on patients suggest an association between anatomical variations in the Circle of Willis (CoW) and intracranial aneurysms (IA), but it is unclear whether this association is present in the general population. ...

    • Anbefalingene for antibiotikabehandling av sepsis diskuteres, særlig bruken av aminoglykosider. Utkast til reviderte anbefalinger er lagt ut til åpen høring. 

      Wæhre, Torgun; Waagsbø, Bjørn; Jordal, Stina; Indrebø, Eirik Müller; Wang, Hege; Akselsen, Per Espen (Peer reviewed; Journal article, 2022)
      Nasjonal faglig retningslinje for antibiotikabruk i sykehus er under oppdatering (1). Så langt er åtte reviderte terapikapitler publisert. Kapittelet med anbefalinger for antibiotikabehandling ved sepsis og mistenkt sepsis ...

    • Anbefalinger om bruk av rotavirusvaksine i Norge 

      Døllner, Henrik; Flem, elmira; Realfsen, Astrid; Rojahn, Astrid; Steenberg, Dianne; Sandbu, Synne; Vainio, Kirsti; Willbergh, Kine (rapport Nasjonalt folkehelseinstitutt;, Research report, 2013)
      Rotavirus smitter vanligvis ved nærkontakt og gir magesyke (gastroenteritt) som rammer praktisk talt alle barn i verden før de fyller fem år. Globalt er dette en viktig dødsårsak for spedbarn. I Norge er rotavirussykdom ...

    • The ANeED study – ambroxol in new and early dementia with Lewy bodies (DLB): protocol for a phase IIa multicentre, randomised, double-blinded and placebo-controlled trial 

      Chwiszczuk, Luiza; Breitve, Monica Haraldseid; Kirsebom, Bjørn-Eivind; Selnes, Per; Fløvig, John Christian Jøraholmen; Knapskog, Anne Brita; Skogseth, Ragnhild Eide; Hubbers, Jessica; Holst-Larsen, Elin; Rongve, Arvid (Peer reviewed; Journal article, 2023)
      Background: Currently, there are no disease-modifying pharmacological treatment options for dementia with Lewy bodies (DLB). The hallmark of DLB is pathological alpha-synuclein (aS) deposition. There are growing amounts ...

    • Anesthesia for Cesarean Delivery: A Cross-Sectional Survey of Provincial, District, and Mission Hospitals in Zimbabwe 

      Lonnee, Herman; Madzimbamuto, Farai; Erlandsen, Ole RM; Vassenden, Astrid; Chikumba, Edson; Dimba, Rutendo; Myhre, Arne Kristian; Ray, Sunanda (Journal article; Peer reviewed, 2017)
      Abstract BACKGROUND: Cesarean delivery is the most common surgical procedure in low- and middle-income countries, so provision of anesthesia services can be measured in relation to it. This study aimed to assess the type ...

    • Animal models to study the role of long-term hypergastrinemia in gastric carcinogenesis 

      Fossmark, Reidar; Qvigstad, Gunnar; Martinsen, Tom Christian; Hauso, Øyvind; Waldum, Helge (Journal article; Peer reviewed, 2011)
      Patients with chronic hypergastrinemia due to chronic atrophic gastritis or gastrinomas have an increased risk of developing gastric malignancy, and it has been questioned whether also patients with hypergastrinemia caused ...