• ACL Reconstruction Patients Have Increased Risk of Knee Arthroplasty at 15 Years of Follow-up : Data from the Norwegian Knee Ligament Register and the Norwegian Arthroplasty Register from 2004 to 2020 

      Visnes, Håvard; Gifstad, Tone; Persson, Andreas; Lygre, Stein Håkon Låstad; Engebretsen, Lars; Drogset, Jon Olav; Furnes, Ove Nord (Peer reviewed; Journal article, 2022)
      Background:  Anterior cruciate ligament (ACL) injury is considered a risk factor for osteoarthritis. The primary aim of the present study was to investigate the cumulative risk of, and risk factors associated with, a ...
    • Active conventional treatment and three different biological treatments in early rheumatoid arthritis: Phase IV investigator initiated, randomised, observer blinded clinical trial 

      Hetland, Merete Lund; Haavardsholm, Espen A.; Rudin, Anna; Nordström, Dan C.; Nurmohamed, Michael; Gudbjornsson, Bjorn; Lampa, Jon; Hørslev-Petersen, Kim; Uhlig, Till; Grondal, Gerdur; Østergaard, Mikkel; Schrumpf, Marte; Twisk, Jos; Lend, Kristina; Krabbe, Simon; Hyldstrup, Lise; Lindqvist, Joakim; Hultgård Ekwall, Anna-Karin; Grøn, Kathrine Lederballe; Kapetanovic, Meliha C.; Faustini, Francesca; Tuompo, Riitta; Lorenzen, Tove; Cagnotto, Giovanni; Baecklund, Eva; Hendricks, Oliver; Vedder, Daisy; Sokka-Isler, Tuulikki; Husmark, Tomas; Ljoså, Maud-Kristine Aga; Brodin, Eli; Ellingsen, Torkell; Söderbergh, Annika; Rizk, Milad; Olsson, Åsa Reckner; Larsson, Per; Uhrenholt, Line; Just, Søren Andreas; Stevens, David John; Laurberg, Trine Bay; Bakland, Gunnstein; Olsen, Inge Christoffer; Vollenhoven, Ronald F. (Peer reviewed; Journal article, 2020)
      Objective To evaluate and compare benefits and harms of three biological treatments with different modes of action versus active conventional treatment in patients with early rheumatoid arthritis. Design Investigator ...
    • Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors 

      Olsen, Oddrun Elise; Hella, Hanne; Elsaadi, Samah; Jacobi, Carsten; Martinez-Hackert, Erik; Holien, Toril (Peer reviewed; Journal article, 2020)
      Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway. In some cases, activins also signal via the ...
    • Acute Diffusion Tensor and Kurtosis Imaging and Outcome following Mild Traumatic Brain Injury 

      Stenberg, Jonas; Eikenes, Live; Moen, Kent Gøran; Vik, Anne; Håberg, Asta; Skandsen, Toril (Peer reviewed; Journal article, 2021)
      In this prospective cohort study, we investigated associations between acute diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) metrics and persistent post-concussion symptoms (PPCS) 3 months after mild ...
    • Acute kidney injury in patients with COVID-19 in the intensive care unit: Evaluation of risk factors and mortality in a national cohort 

      Aukland, Eirik Aasen; Klepstad, Pål; Aukland, Stein Magnus; Zamanzad Ghavidel, Fatemeh; Buanes, Eirik Alnes (Peer reviewed; Journal article, 2022)
      Objectives Acute kidney injury (AKI) is a frequent complication among critical ill patients with COVID-19, but the actual incidence is unknown as AKI-incidence varies from 25% to 89% in intensive care unit (ICU) populations. ...
    • Admissions and surgery as indicators of hospital functions in Sierra Leone during the west-African Ebola outbreak 

      Bolkan, Håkon Angell; van Duinen, Aalke Johan; Samai, Mohammed; Bash-Taqi, Donald Alpha; Gassama, Ibarahim; Waalewijn, Bart; Wibe, Arne; von Schreeb, Johan (Journal article; Peer reviewed, 2018)
      Background In an attempt to assess the effects of the Ebola viral disease (EVD) on hospital functions in Sierra Leone, the aim of this study was to evaluate changes in provisions of surgery and non-Ebola admissions during ...
    • Adolescent siblings of children with cancer: a qualitative study from a salutogenic health promotion perspective 

      Løkkeberg, Birgit; Sollesnes, Ragnhild; Hestvik, Jorun; Langeland, Eva (Peer reviewed; Journal article, 2020)
      Purpose: To explore the experiences of adolescents with a sibling suffering from cancer from a salutogenic health promotion perspective. Methods: Seven female siblings aged 13–17 years were interviewed. The interviews ...
    • Adverse childhood experiences and their association with substance use disorders in adulthood: A general population study (Young-HUNT) 

      Broekhof, Rosalie; Nordahl, Hans Morten; Tanum, Lars Håkon Reiestad; Selvik, Sara Germans (Peer reviewed; Journal article, 2023)
      Aim To investigate the association of adverse childhood experiences (ACEs) and substance use disorders (alcohol and illicit drug use disorders), specifically by gender, in a large longitudinal non-clinical population ...
    • Adverse events of exercise therapy in randomised controlled trials: A systematic review and meta-analysis 

      Niemeijer, Andre; Lund, Hans; Stafne, Signe Nilssen; Ipsen, Thomas; Goldschmidt, Cathrine Luhaäär; Jørgensen, Claus Thomas; Juhl, Carsten B. (Journal article; Peer reviewed, 2019)
      Objective To evaluate the relative risk (RR) of serious and non-serious adverse events in patients treated with exercise therapy compared with those in a non-exercising control group. Design Systematic review and ...
    • Adverse events with fatal outcome associated with alemtuzumab treatment in multiple sclerosis 

      Holmøy, Trygve; Fevang, Børre; Olsen, David Benee; Spigset, Olav; Bø, Lars (Journal article; Peer reviewed, 2019)
      Objective Sporadic fatal adverse events have been reported during treatment of multiple sclerosis with alemtuzumab. To provide a systematic overview, we searched the centralized European Medicines Agency database of ...
    • Adverse pregnancy outcomes among women in Norway with gestational diabetes using three diagnostic criteria 

      Rai, Anam Shakil; Sletner, Line; Jenum, Anne Karen; Øverby, Nina Cecilie; Stafne, Signe Nilssen; Qvigstad, Elisabeth; Pripp, Are Hugo; Sagedal, Linda (Peer reviewed; Journal article, 2023)
      Introduction The aim of this study was to examine the risk of adverse perinatal outcomes in women diagnosed with GDM by the World Health Organization (WHO) 1999 criteria, and in those retrospectively identified by the ...
    • Aerobic high-intensity intervals improve V̇O2max more than supramaximal sprint intervals in females, similar to males 

      Helgerud, Jan; Hov, Håkon; Mehus, Håkon Andre; Balto, Bård; Boye, Anders Johan Nesheim; Finsås, Lars; Hoff, Jan; Wang, Eivind (Journal article; Peer reviewed, 2023)
      Introduction: Maximal oxygen uptake (V̇O2max) is a pivotal factor for aerobic endurance performance. Recently, aerobic high-intensity interval training (HIIT) was documented to be superior to sprint interval training (SIT) ...
    • Age at Menarche, age at Natural Menopause, and Risk of Lung and Colorectal Cancers: A Mendelian Randomization Study 

      Dénos, Marion Nicole Marie; Sun, Yi-Qian; Jiang, Lin; Brumpton, Ben Michael; Mai, Xiao-Mei (Peer reviewed; Journal article, 2023)
      Background: The roles of age at menarche and age at menopause in the etiology of lung and colorectal cancers are unclear. Objective: We aimed to investigate potential causal associations between age at menarche, age at ...
    • Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease 

      Egiazarian, Milena Armenovna; Strømstad, Silje; Sakshaug, Teri; Nunez-Nescolarde, Ana; Bethge, Nicole; Bjørås, Magnar; Scheffler, Katja (Peer reviewed; Journal article, 2022)
      Oxidative stress generating DNA damage has been shown to be a key characteristic in Alzheimer's disease (AD). However, how it affects the pathogenesis of AD is not yet fully understood. Neil3 is a DNA glycosylase initiating ...
    • Age-of-onset information helps identify 76 genetic variants associated with allergic disease 

      Ferreira, Manuel A R; Vonk, Judith M.; Baurecht, Hansjörg; Marenholz, Ingo; Tian, Chao; Hoffman, Joshua D.; Helmer, Quinta; Tillander, Annika; Ullemar, Vilhelmina; Lu, Yi; Grosche, Sarah; Ruschendorf, Franz; Granell, Raquel; Brumpton, Ben Michael; Fritsche, Lars; Bhatta, Laxmi; Gabrielsen, Maiken Elvestad; Nielsen, Jonas Bille; Zhou, Wei; Hveem, Kristian; Langhammer, Arnulf; Holmen, Oddgeir; Løset, Mari; Abecasis, Goncalo; Willer, Cristen J.; Emami, Nima C.; Cavazos, Taylor B.; Witte, John S.; Szwajda, Agnieszka; 23andMe Research Team, ,; collaborators of SHARE study, ,; Hinds, David A.; Hubner, Norbert; Weidinger, Stephan; Magnusson, Patrik KE; Jorgenson, Eric; Karlsson, Robert; Paternoster, Lavinia; Boomsma, Dorret I.; Almqvist, Catarina; Lee, Young-Ae; Koppelman, Gerard H.; Esparza-Gordillo, Jorge; Hummel, Oliver; Hottenga, Jouke-Jan; Willemsen, Gonneke; Rodríguez, Elke; Hotze, Melanie; Franke, Andre; Matheson, Melanie C.; Dharmage, Shyamali Chandrika; Arnold, Andreas; Homuth, Georg; Schmidt, Carsten O; Thompson, Philip J.; Martin, Nicholas G; Duffy, David L.; Novak, Natalija; Schulz, Holger; Karrasch, Stefan; Gieger, Christian; Strauch, Konstantin; Melles, Ronald B (Peer reviewed; Journal article, 2020)
      Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which ...
    • AI-driven attenuation correction for brain PET/MRI: Clinical evaluation of a dementia cohort and importance of the training group size 

      Ladefoged, Claes Nøhr; Hansen, Adam Espe; Henriksen, Otto Mølby; Bruun, Frederik Jager; Eikenes, Live; Øen, Silje Kjærnes; Karlberg, Anna Maria; Højgaard, Liselotte; Law, Ian; Andersen, Flemming Littrup (Peer reviewed; Journal article, 2020)
      Introduction Robust and reliable attenuation correction (AC) is a prerequisite for accurate quantification of activity concentration. In combined PET/MRI, AC is challenged by the lack of bone signal in the MRI from which ...
    • Aids to management of headache disorders in primary care (2nd edition): On behalf of the European Headache Federation and Lifting the Burden: The Global Campaign against Headache 

      Steiner, Timothy J.; Jensen, Rigmor Højland; Katsarava, Zaza; Linde, Mattias; MacGregor, E. Anne; Osipova, Vera; Paemeleire, Koen; Olesen, Jes; Peters, Michele; Martelletti, Paolo (Journal article; Peer reviewed, 2019)
      The Aids to Management are a product of the Global Campaign against Headache, a worldwide programme of action conducted in official relations with the World Health Organization. Developed in partnership with the European ...
    • Akutt lungesviktsyndrom hos covid-19-pasient med negative nasofarynksprøver 

      Hauge, Marit Teigen; Nilsen, Einar; Nordseth, Trond (Peer reviewed; Journal article, 2020)
      En kvinne i 40-årene som ble innlagt etter tre ukers sykehistorie med luftveisinfeksjon, utviklet alvorlig akutt lungesviktsyndrom. Nasofarynksprøver tatt dag 1 og 3 etter innleggelse var negative for sars-CoV-2-viruset, ...
    • Akutte laparotomier ved St. Olavs hospital 

      Wangen, Endre; Gillund, Even Westgaard; Reinholdtsen, Eirik Midtgaard; Henriksveen, Kristian Jostad; van Duinen, Aalke Johan; Faqiri, Mirwais; Ystgaard, Brynjulf; Bolkan, Håkon Angell (Peer reviewed; Journal article, 2023)
      BAKGRUNN Akutte laparotomier er assosiert med høyere mortalitet og lengre sykehusopphold enn elektive laparotomier. Formålet med denne studien var å kartlegge pasientkarakteristika, sykehusforløp og mortalitet for dem som ...
    • Alendronate and omeprazole in combination reduce angiogenic and growth signals from osteoblasts 

      Kruger, Tormod Bjartveit; Herlofson, Bente Brokstad; Lian, Aina-Mari; Syversen, Unni; Reseland, Janne Elin (Peer reviewed; Journal article, 2021)
      Objective: Due to gastrointestinal side effects of oral bisphosphonates (BPs), proton pump inhibitors (PPIs) are often prescribed. PPIs may enhance the risk of osteonecrosis of the jaw, a rare side effect of BPs. Therefore, ...