• Cardiovascular outcomes at recommended blood pressure targets in middle-aged and elderly patients with type 2 diabetes mellitus compared to all middle-aged and elderly hypertensive study patients with high cardiovascular risk 

      Olsen, Erik; Holzhauer, Björn; Julius, Stevo; Kjeldsen, Sverre; Larstorp, Anne Cecilie Kjeldsen; Mancia, Giuseppe; Mehlum, Maria Hollund; Mo, Rune; Rostrup, Morten; Søraas, Camilla Lund; Zappe, Dion H.; Weber, Michael A. (Peer reviewed; Journal article, 2021)
      Purpose Event-based clinical outcome trials have shown limited evidence to support guidelines recommendations to lower blood pressure (BP) to <130/80 mmHg in middle-aged and elderly hypertensive patients with diabetes ...
    • Care transitions in the first 6 months following traumatic brain injury: Lessons from the CENTER-TBI study 

      Borgen, Ida Maria Henriksen; Røe, Cecilie; Brunborg, Cathrine; Tenovuo, Olli; Azouvi, Philippe; Dawes, Helen; Majdan, Marek; Ranta, Jukka; Rusnak, Martin; Wiegers, E; Tverdal, Cathrine Buaas; Jacob, Louis; Cogne, Melanie; von Steinbuechel, Nicole; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røise, Olav; Skandsen, Toril; Vik, Anne; Åkerlund, Cecilia; Amrein, Krisztina; Antoni, Anna; Audibert, Gerard; Azzolini, Maria Luisa; Bartels, Ronald; Barzo, Pal; Beauvais, Romuald; Beer, Ronny; Bellander, Bo-Michael; Belli, Antonio; Benali, Habib; Berardino, Maurizio; Beretta, Luigi; Blaabjerg, Morten; Bragge, Peter; Brazinova, Alexandra; Brinck, Vibeke; Brooker, Joanne; Brorsson, Camilla; Buki, Andras; Bullinger, Monika; Cabeleira, Manuel; Caccioppola, Alessio; Calappi, Emiliana; Calvi, Maria Rosa; Cameron, Peter; Lozano, Guillermo Carbayo (Peer reviewed; Journal article, 2021)
      Background: No large international studies have investigated care transitions during or after acute hospitalisations for traumatic brain injury (TBI). Objectives: To characterise various TBI-care pathways and the number ...
    • Caregiving, Participation, and Quality of Life of Closest Next of Kin of Persons Living with Spinal Cord Injury in Norway 

      Halvorsen, Annette; Pape, Kristine; Post, Marcel; Biering-Sørensen, Fin; Engelsjord, Monica; Steinsbekk, Aslak (Peer reviewed; Journal article, 2022)
      Objectives: To investigate how next of kin of persons with spinal cord injury (SCI) experience various life areas in terms of caregiving, participation, and quality of life, and the impact of personal characteristics of ...
    • Carfilzomib and dexamethasone maintenance following salvage ASCT in multiple myeloma: A randomised phase 2 trial by the Nordic Myeloma Study Group 

      Gregersen, Henrik; Peceliunas, Valdas; Remes, Kari; Schjesvold, Fredrik Hellem; Abildgaard, Niels; Nahi, Hareth; Andersen, Niels Frost; Vangsted, Annette Juul; Klausen, Tobias Wirenfeldt; Helleberg, Carsten; Carlson, Kristina; Frølund, Ulf Christian; Axelsson, Per; Stromberg, Olga; Blimark, Cecilie Hveding; Crafoord, Jacob; Tsykunova, Galina; Eshoj, Henrik Rode; Waage, Anders; Hansson, Markus; Gulbrandsen, Nina (Peer reviewed; Journal article, 2021)
      Objective We investigated the efficacy and safety of carfilzomib-containing induction before salvage high-dose melphalan with autologous stem-cell transplantation (salvage ASCT) and maintenance with carfilzomib and ...
    • Catastrophic expenditure and impoverishment after caesarean section in Sierra Leone: An evaluation of the free health care initiative 

      van Duinen, Aalke Johan; Westendorp, Josien; Ashley, Thomas; Hagander, Lars; Holmer, Hampus; Koroma, Alimamy P.; Leather, Andy J.M.; Shrime, Mark G.; Wibe, Arne; Bolkan, Håkon Angell (Peer reviewed; Journal article, 2021)
      Background Utilizing surgical services, including caesarean sections, can result in catastrophic expenditure and impoverishment. In 2010, Sierra Leone introduced the Free Health Care Initiative (FHCI), a national financial ...
    • CCND1 amplification in breast cancer -associations with proliferation, histopathological grade, molecular subtype and prognosis 

      Valla, Marit; Klæstad, Elise; Ytterhus, Borgny; Bofin, Anna M. (Peer reviewed; Journal article, 2022)
      CCND1 is located on 11q13. Increased CCND1 copy number (CN) in breast cancer (BC) is associated with high histopathological grade, high proliferation, and Luminal B subtype. In this study of CCND1 in primary BCs and ...
    • Cementless unicompartmental knee arthroplasty results in higher pain levels compared to the cemented technique: a prospective register study 

      Gifstad, Tone; Nordskar, Jørgen Jebens; Egeberg, Tarjei; Wik, Tina Strømdal; Winther, Siri Bjørgen (Peer reviewed; Journal article, 2021)
      Purpose In recent years, the preferred fxation method for unicompartmental knee arthroplasty (UKA) has changed from cemented to cementless. The aim of this study was to compare patient-reported outcome measures (PROMs) ...
    • CENIT (Impact of Cardiac Exercise Training on Lipid Content in Coronary Atheromatous Plaques Evaluated by Near-Infrared Spectroscopy): A Randomized Trial 

      Vesterbekkmo, Elisabeth Kleivhaug; Madssen, Erik; Aksetøy, Inger-Lise Aamot; Follestad, Turid; Nilsen, Hans-Olav; Hegbom, Knut; Wisløff, Ulrik; Wiseth, Rune (Peer reviewed; Journal article, 2022)
      Background The effect of physical exercise on lipid content of coronary artery plaques is unknown. With near infrared spectroscopy we measured the effect of high intensity interval training (HIIT) on lipid content in ...
    • Central Pathology Review in SENTIX, A Prospective Observational International Study on Sentinel Lymph Node Biopsy in Patients with Early-Stage Cervical Cancer (ENGOT-CX2) 

      Nemejcova, Kristyna; Kocian, Roman; Kohler, Christhardt; Jarkovsky, Jiri; Klat, Jaroslav; Berjon, Alberto; Pilka, Radovan; Sehnal, Borek; Gil-Ibanez, Blanca; Lupo, Ezequiel; Petiz, Almerinda; Sanchez, Octavio Arencibia; Kascak, Peter; Martinelli, Fabio; Buda, Alessandro; Presl, Jiri; Barahona, Marc; van Lonkhuijzen, Luc; Szatkowski, Wiktor; Minar, Lubos; Pakiz, Maja; Havelka, Pavel; Zorrero, Christina; Misiek, Marcin; Snyman, Leon Cornelius; Wydra, Dariusz; Vergote, Ignace; Vinnytska, Alla; Redecha, Mikulas; Michal, Martin; Tingulstad, Solveig Kristi; Kipp, Barbara; Szewczyk, Grzegorz; Toth, Robert; de Santiago Garcia, Francisco Javier; Coronado Martin, Pluvio Jesus; Poka, Robert; Tamussino, Karl; Luyckx, Mathieu; Fastrez, Maxime; Staringer, Juan Carlos; Germanova, Anna; Plaikner, Andrea; Bajsova, Sylva; Dundr, Pavel; Mallmann-Gottschalk, Nina; Cibula, David (Peer reviewed; Journal article, 2020)
      The quality of pathological assessment is crucial for the safety of patients with cervical cancer if pelvic lymph node dissection is to be replaced by sentinel lymph node (SLN) biopsy. Central pathology review of SLN ...
    • The central role of gastrin in gastric cancer 

      Waldum, Helge; Mjønes, Patricia Gjertrud (Peer reviewed; Journal article, 2023)
      The prevalence of gastric cancer has markedly declined, but due to the high mortality rates associated with gastric cancer, it is still a serious disease. The preferred classification of gastric cancer is according to ...
    • Centralizing a national pancreatoduodenectomy service: striking the right balance 

      Nymo, Linn Såve; Kleive, Dyre; Waardal, Kim; Bringeland, Erling Audun; Søreide, Jon Arne; Labori, Knut Jørgen; Mortensen, Kim Erlend; Søreide, Kjetil; Lassen, Kristoffer (Peer reviewed; Journal article, 2020)
      Background Centralization of pancreatic surgery is currently called for owing to superior outcomes in higher‐volume centres. Conversely, organizational and patient concerns speak for a moderation in centralization. Consensus ...
    • Cerebellar mutism syndrome in children with brain tumours of the posterior fossa 

      Wibroe, Morten; Cappelen, Johan; Castor, Charlotte; Clausen, Niels; Grillner, Pernilla; Gudrunardottir, Thora; Gupta, Ramneek; Gustavsson, Bengt; Heyman, Mats; Holm, Stefan; Karppinen, Atte; Klausen, Camilla; Lönnqvist, Tuula; Mathiasen, Rene; Nilsson, Pelle; Nysom, Karsten; Persson, Karin; Rask, Olof; Schmiegelow, Kjeld; Sehested, Astrid; Thomassen, Harald; Tonning-Olsson, Ingrid; Zetterqvist, Barbara; Juhler, Marianne (Peer reviewed; Journal article, 2017)
      Background: Central nervous system tumours constitute 25% of all childhood cancers; more than half are located in the posterior fossa and surgery is usually part of therapy. One of the most disabling late effects of posterior ...
    • Cerebral cortical dimensions in headache sufferers aged 50-66 years: a population-based imaging study in the Nord-Trondelag Health Study (HUNT-MRI) 

      Husøy, Andreas Kattem; Håberg, Asta Kristine; Rimol, Lars Morten; Hagen, Knut; Vangberg, Torgil Riise; Stovner, Lars Jacob (Journal article; Peer reviewed, 2019)
      Based on previous clinic-based magnetic resonance imaging studies showing regional differences in the cerebral cortex between those with and without headache, we hypothesized that headache sufferers have a decrease in ...
    • Cerebrospinal Fluid Concentration of Key Autophagy Protein Lamp2 Changes Little During Normal Aging 

      Loeffler, David A.; Klaver, Andrea C.; Coffey, Mary P.; Aasly, Jan (Peer reviewed; Journal article, 2018)
      Autophagy removes both functional and damaged intracellular macromolecules from cells via lysosomal degradation. Three autophagic mechanisms, namely macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy, ...
    • Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults 

      Hemminghyth, Mathilde Suhr; Chwiszczuk, Luiza; Breitve, Monica Haraldseid; Gisladottir, Berglind; Grøntvedt, Gøril Rolfseng; Nakling, Arne Exner; Rongve, Arvid; Fladby, Tormod; Kirsebom, Bjørn-Eivind Seljelid (Peer reviewed; Journal article, 2023)
      Multiple cognitive domains, including learning, memory, and psychomotor speed, show significant reductions with age. Likewise, several cerebrospinal fluid (CSF) neurodegenerative biomarkers, including total tau (t-tau, a ...
    • Cerebrospinal fluid sTREM2 in Alzheimer’s disease: comparisons between clinical presentation and AT classification 

      Knapskog, Anne Brita; Henjum, Kristi; Idland, Ane-Victoria; Eldholm, Rannveig Sakshaug; Persson, Karin Ester Torun; Saltvedt, Ingvild; Watne, Leiv; Engedal, Knut; Nilsson, Lars N.G. (Peer reviewed; Journal article, 2020)
      Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed by microglia. Its cleaved fragments, soluble TREM2 (sTREM2), can be measured in the cerebrospinal fluid (CSF). Previous studies ...
    • Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial 

      Østergaard, Mikkel; Van Vollenhoven, Ronald F; Rudin, Anna; Hetland, Merete Lund; Schrumpf, Marte; Nordström, Dan C; Nurmohamed, Michael T; Gudbjornsson, Bjorn; Ørnbjerg, Lykke Midtbøll; Bøyesen, Pernille; Lend, Kristina; Hørslev-Petersen, Kim; Uhlig, Till; Sokka, Tuulikki; Grondal, Gerdur; Krabbe, Simon; Lindqvist, Joakim; Gjertsson, Inger; Glinatsi, Daniel; Kapetanovic, Meliha Crnkic; Aga, Anna-Birgitte; Faustini, Francesca; Parmanne, Pinja; Lorenzen, Tove; Giovanni, Cagnotto; Back, Johan; Hendricks, Oliver; Vedder, Daisy; Rannio, Tuomas; Grenholm, Emma; Ljoså, Maud-Kristine Aga; Brodin, Eli; Lindegaard, Hanne; Söderbergh, Annika; Rizk, Milad; Kastbom, Alf; Larsson, Per; Uhrenholt, Line; Just, Søren Andreas; Stevens, David John; Bay Laurbjerg, Trine; Bakland, Gunnstein; Olsen, Inge Christoffer; Haavardsholm, Espen A.; Lampa, Jon (Peer reviewed; Journal article, 2023)
      Background - The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with ...
    • Challenges with benchmarking of MDMA-assisted psychotherapy 

      Halvorsen, Joar Øveraas; Naudet, Florian; Cristea, Ioana A. (Peer reviewed; Journal article, 2021)
      To represent a treatment breakthrough, 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder (PTSD) should be evaluated against first-line psychological interventions or for ...
    • Change in Headache Suffering and Predictors of Headache after Mild Traumatic Brain Injury: A Population-Based, Controlled, Longitudinal Study with Twelve-Month Follow-Up 

      Nordhaug, Lena Hoem; Linde, Mattias; Follestad, Turid; skandsen, øystein njølstad; Bjarkø, Vera Vik; Skandsen, Toril; Vik, Anne (Journal article; Peer reviewed, 2019)
      Headache attributed to traumatic injury to the head (HAIH) is claimed to be the most common sequela following mild traumatic brain injury (MTBI), but epidemiological evidence is scarce. We explored whether patients with ...
    • Change in interpersonal problems and metacognitive beliefs as predictors of improvement in patients with generalized anxiety disorder 

      Strand, Eivind Rauø; Hjemdal, Odin; Anyan, Frederick; Nordahl, Henrik; Nordahl, Hans Morten (Peer reviewed; Journal article, 2023)
      Introduction Generalized anxiety disorder (GAD) is characterized by persistent worry and anxiety, often with a chronic course. We tested the role of two suggested underlying factors in GAD, interpersonal problems and ...