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dc.contributor.authorSun, Yi-Qian
dc.contributor.authorBurgess, Stephen
dc.contributor.authorStaley, James R.
dc.contributor.authorWood, Angela M.
dc.contributor.authorBell, Steven
dc.contributor.authorKaptoge, Stephen
dc.contributor.authorGuo, Qi
dc.contributor.authorBolton, Thomas R.
dc.contributor.authorMason, Amy M
dc.contributor.authorButterworth, Adam S.
dc.contributor.authorDi Angelantonio, Emanuele
dc.contributor.authorVie, Gunnhild Åberge
dc.contributor.authorBjørngaard, Johan Håkon
dc.contributor.authorKinge, Jonas Minet
dc.contributor.authorChen, Yue
dc.contributor.authorMai, Xiao-Mei
dc.description.abstractObjective To investigate the shape of the causal relation between body mass index (BMI) and mortality. Design Linear and non-linear mendelian randomisation analyses. Setting Nord-Trøndelag Health (HUNT) Study (Norway) and UK Biobank (United Kingdom). Participants Middle to early late aged participants of European descent: 56 150 from the HUNT Study and 366 385 from UK Biobank. Main outcome measures All cause and cause specific (cardiovascular, cancer, and non-cardiovascular non-cancer) mortality. Results 12 015 and 10 344 participants died during a median of 18.5 and 7.0 years of follow-up in the HUNT Study and UK Biobank, respectively. Linear mendelian randomisation analyses indicated an overall positive association between genetically predicted BMI and the risk of all cause mortality. An increase of 1 unit in genetically predicted BMI led to a 5% (95% confidence interval 1% to 8%) higher risk of mortality in overweight participants (BMI 25.0-29.9) and a 9% (4% to 14%) higher risk of mortality in obese participants (BMI ≥30.0) but a 34% (16% to 48%) lower risk in underweight (BMI <18.5) and a 14% (−1% to 27%) lower risk in low normal weight participants (BMI 18.5-19.9). Non-linear mendelian randomisation indicated a J shaped relation between genetically predicted BMI and the risk of all cause mortality, with the lowest risk at a BMI of around 22-25 for the overall sample. Subgroup analyses by smoking status, however, suggested an always-increasing relation of BMI with mortality in never smokers and a J shaped relation in ever smokers. Conclusions The previously observed J shaped relation between BMI and risk of all cause mortality appears to have a causal basis, but subgroup analyses by smoking status revealed that the BMI-mortality relation is likely comprised of at least two distinct curves, rather than one J shaped relation. An increased risk of mortality for being underweight was only evident in ever smokers.nb_NO
dc.publisherBMJ Publishing Groupnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleBody mass index and all cause mortality in HUNT and UK Biobank studies: linear and non-linear mendelian randomisation analysesnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.localcodeThis is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See:
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal