dc.contributor.author | Vardaxis, Ioannis | |
dc.contributor.author | Drabløs, Finn | |
dc.contributor.author | Rye, Morten Beck | |
dc.contributor.author | Lindqvist, Bo Henry | |
dc.date.accessioned | 2019-04-26T08:21:34Z | |
dc.date.available | 2019-04-26T08:21:34Z | |
dc.date.created | 2019-02-02T22:29:46Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1465-4644 | |
dc.identifier.uri | http://hdl.handle.net/11250/2595623 | |
dc.description.abstract | We present model-based analysis for ChIA-PET (MACPET), which analyzes paired-end read sequences provided by ChIA-PET for finding binding sites of a protein of interest. MACPET uses information from both tags of each PET and searches for binding sites in a two-dimensional space, while taking into account different noise levels in different genomic regions. MACPET shows favorable results compared with MACS in terms of motif occurrence and spatial resolution. Furthermore, significant binding sites discovered by MACPET are involved in a higher number of significant three-dimensional interactions than those discovered by MACS. MACPET is freely available on Bioconductor. ChIA-PET; MACPET; Model-based clustering; Paired-end tags; Peak-calling algorithm. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Oxford University Press | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | MACPET: model-based analysis for ChIA-PET | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.journal | Biostatistics | nb_NO |
dc.identifier.doi | 10.1093/biostatistics/kxy084 | |
dc.identifier.cristin | 1672665 | |
dc.description.localcode | © The Author 2019. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Supplementary data | nb_NO |
cristin.unitcode | 194,63,15,0 | |
cristin.unitcode | 194,65,15,0 | |
cristin.unitname | Institutt for matematiske fag | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |