Show simple item record

dc.contributor.authorRimol, Lars Morten
dc.contributor.authorBotellero, Violeta NL
dc.contributor.authorBjuland, Knut Jørgen
dc.contributor.authorLøhaugen, Gro
dc.contributor.authorLydersen, Stian
dc.contributor.authorEvensen, Kari Anne Indredavik
dc.contributor.authorBrubakk, Ann-Mari
dc.contributor.authorEikenes, Live
dc.contributor.authorIndredavik, Marit Sæbø
dc.contributor.authorMartinussen, Marit
dc.contributor.authorYendiki, Anastasia
dc.contributor.authorHåberg, Asta
dc.contributor.authorSkranes, Jon Sverre
dc.identifier.citationNeuroImage. 2018, 188 217-227.nb_NO
dc.description.abstractDevelopment of the cerebral cortex may be affected by aberrant white matter development. Preterm birth with very low birth weight (VLBW) has been associated with reduced fractional anisotropy of white matter and changes in cortical thickness and surface area. We use a new methodological approach to combine white and gray matter data and test the hypothesis that white matter injury is primary, and acts as a mediating factor for concomitant gray matter aberrations, in the developing VLBW brain. T1 and dMRI data were obtained from 47 young adults born preterm with VLBW and 73 term-born peers (mean age = 26). Cortical thickness was measured across the cortical mantle and compared between the groups, using the FreeSurfer software suite. White matter pathways were reconstructed with the TRACULA software and projected to their cortical end regions, where cortical thickness was averaged. In the VLBW group, cortical thickness was increased in anteromedial frontal, orbitofrontal, and occipital regions, and fractional anisotropy (FA) was reduced in frontal lobe pathways, indicating compromised white matter integrity. Statistical mediation analyses demonstrated that increased cortical thickness in the frontal regions was mediated by reduced FA in the corpus callosum forceps minor, consistent with the notion that white matter injury can disrupt frontal lobe cortical development. Combining statistical mediation analysis with pathway projection onto the cortical surface offers a powerful novel tool to investigate how cortical regions are differentially affected by white matter injury.nb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleReduced white matter fractional anisotropy mediates cortical thickening in adults born preterm with very low birthweight.nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.identifier.doi10.1016/j.neuroimage. 2018.11.050
dc.description.localcode© 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( ).nb_NO
cristin.unitnameInstitutt for psykologi
cristin.unitnameRKBU Midt-Norge - Regionalt kunnskapssenter for barn og unge - psykisk helse og barnevern
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal