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dc.contributor.authorZotcheva, Ekaterina
dc.contributor.authorPintzka, Carl Wolfgang Schøyen
dc.contributor.authorSalvesen, Øyvind
dc.contributor.authorSelbæk, Geir
dc.contributor.authorHåberg, Asta
dc.contributor.authorErnstsen, Linda
dc.identifier.citationFrontiers in Behavioral Neuroscience. 2019, 13 1-9.nb_NO
dc.description.abstractObjective: We investigated the independent and joint associations of changes in estimated cardiorespiratory fitness (eCRF) and symptoms of anxiety and depression with brain volumes in individuals from the general population. Method: 751 participants (52% women, aged 50–67 years) from the Nord-Trøndelag Health Study (HUNT) MRI cohort were included. eCRF obtained from a non-exercise algorithm and symptoms of anxiety and depression were assessed twice; at HUNT2 (1995–97) and HUNT3 (2006–08). Brain MRI was performed shortly after HUNT3. Brain parenchymal fraction (BPF), bilateral hippocampal and total cortical volume were extracted from brain MRI obtained at 1.5T, using FreeSurfer and Statistical Parametric Mapping. Results: Multiple regression revealed that participants whose eCRF increased had larger BPF (β = 0.09, 95% CI 0.02, 0.16) and larger hippocampal volume (β = 0.09, 95% CI 0.03, 0.16) compared to participants whose eCRF remained low. Participants whose eCRF remained high had larger BPF (β = 0.15, 95% CI 0.07, 0.22) and larger cortical volume (β = 0.05, 95% CI 0.01, 0.09). Participants whose anxiety symptoms worsened had smaller BPF (β = −0.09, 95% CI −0.15, −0.02) and cortical volume (β = −0.05, −0.08, −0.01) than participants whose anxiety symptoms remained low. Each ml/kg/min increase in eCRF was associated with larger cortical volume among individuals with worsening of anxiety symptoms (β = 0.13, 95% CI 0.001, 0.27), and larger BPF among individuals whose depressive symptoms improved (β = 0.28, 95% CI 0.02, 0.53). Conclusion: Promoting exercise intended to improve eCRF may be an important public health initiative aimed at maintaining brain health among middle-aged individuals with and without changing psychological symptoms.nb_NO
dc.publisherFrontiers Medianb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleAssociations of Changes in Cardiorespiratory Fitness and Symptoms of Anxiety and Depression With Brain Volumes: The HUNT Studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalFrontiers in Behavioral Neurosciencenb_NO
dc.description.localcodeCopyright © 2019 Zotcheva, Pintzka, Salvesen, Selbæk, Håberg and Ernstsen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.nb_NO
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.unitnameMH fakultetsadministrasjon
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap

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Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal