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dc.contributor.authorPhilips, Elise M
dc.contributor.authorKahn, Linda G
dc.contributor.authorJaddoe, Vincent WV
dc.contributor.authorShao, Yongzhao
dc.contributor.authorAsimakopoulos, Alexandros
dc.contributor.authorKannan, Kurunthachalam
dc.contributor.authorSteegers, Eric A.P.
dc.contributor.authorTrasande, Leonardo
dc.date.accessioned2019-03-22T09:06:56Z
dc.date.available2019-03-22T09:06:56Z
dc.date.created2019-01-19T00:11:57Z
dc.date.issued2018
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism. 2018, 103 (9), 3540-3547.nb_NO
dc.identifier.issn0021-972X
dc.identifier.urihttp://hdl.handle.net/11250/2591234
dc.description.abstractBackground Increasing evidence suggests that exposure to synthetic chemicals such as bisphenols and phthalates can influence fecundability. The current study describes associations of first trimester urinary concentrations of bisphenol A (BPA), BPA analogs, and phthalate metabolites with time to pregnancy (TTP). Methods Among 877 participants in the population-based Generation R pregnancy cohort, we measured first trimester urinary concentrations of bisphenols and phthalates [median gestational age, 12.9 weeks (interquartile range, 12.1, 14.4)]. We used fitted covariate-adjusted Cox proportional hazard models to examine associations of bisphenol and phthalate concentrations with TTP. Participants who conceived using infertility treatment were censored at 12 months. Biologically plausible effect measure modification by folic acid supplement use was tested. Results In the main models, bisphenol and phthalate compounds were not associated with fecundability. In stratified models, total bisphenols and phthalic acid were associated with longer TTP among women who did not use folic acid supplements preconceptionally [respective fecundability ratios per each natural log increase were 0.90 (95% CI, 0.81 to 1.00) and 0.88 (95% CI, 0.79 to 0.99)]. Using an interaction term for the exposure and folic acid supplement use showed additional effect measure modification by folic acid supplement use for high-molecular-weight phthalate metabolites. Conclusions We found no associations of bisphenols and phthalates with fecundability. Preconception folic acid supplementation seems to modify effects of bisphenols and phthalates on fecundability. Folic acid supplements may protect against reduced fecundability among women exposed to these chemicals. Further studies are needed to replicate these findings and investigate potential mechanisms.nb_NO
dc.language.isoengnb_NO
dc.publisherOxford University Pressnb_NO
dc.titleFirst Trimester Urinary Bisphenol and Phthalate Concentrations and Time to Pregnancy: A Population-Based Cohort Analysisnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber3540-3547nb_NO
dc.source.volume103nb_NO
dc.source.journalJournal of Clinical Endocrinology and Metabolismnb_NO
dc.source.issue9nb_NO
dc.identifier.doi10.1210/jc.2018-00855
dc.identifier.cristin1660767
dc.description.localcodeThis article will not be available due to copyright restrictions (c) 2018 by Oxford University Pressnb_NO
cristin.unitcode194,66,25,0
cristin.unitnameInstitutt for kjemi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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