dc.contributor.author | Sigurdardottir, Fjola Dogg | |
dc.contributor.author | Lyngbakken, Magnus Nakrem | |
dc.contributor.author | Holmen, Oddgeir Lingaas | |
dc.contributor.author | Dalen, Håvard | |
dc.contributor.author | Hveem, Kristian | |
dc.contributor.author | Røsjø, Helge | |
dc.contributor.author | Omland, Torbjørn | |
dc.date.accessioned | 2019-03-13T11:33:55Z | |
dc.date.available | 2019-03-13T11:33:55Z | |
dc.date.created | 2018-07-01T13:08:51Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | American Journal of Cardiology. 2018, 121 (8), 949-955. | nb_NO |
dc.identifier.issn | 0002-9149 | |
dc.identifier.uri | http://hdl.handle.net/11250/2589841 | |
dc.description.abstract | C-reactive protein and cardiac troponin I measured with high-sensitivity assays (high-sensitivity C-reactive protein [hs-CRP] and high-sensitivity troponin I [hs-TnI]) have been associated with risk of fatal and nonfatal cardiovascular events in the general population. The relative prognostic merits of hs-CRP and hs-TnI, and whether these markers of inflammation and subclinical myocardial injury provide incremental information to established cardiovascular risk prediction models, remain unclear. hs-CRP and hs-TnI were measured in 9,005 participants from the prospective observational Nord-Trøndelag Health (HUNT) study. All study subjects were free from known cardiovascular disease at baseline. During a median follow-up period of 13.9 years, 733 participants reached the composite end point of hospitalization for acute myocardial infarction or heart failure, or cardiovascular death. In adjusted models, increased hs-TnI concentrations (>10 ng/L for women and >12 ng/L for men) were associated with the incidence of the composite end point (hazard ratio 3.61, 95% confidence interval [CI] 2.89 to 4.51]), whereas the risk associated with increased hs-CRP concentrations (>3 mg/L for both genders) appeared to be weaker (HR 1.71, 95% CI 1.40 to 2.10). The addition of hs-TnI to established cardiovascular risk prediction models led to a net reclassification improvement of 0.35 (95% CI 0.27 to 0.42), superior to that of hs-CRP (0.21, 95% CI 0.13 to 0.28). The prognostic accuracy of hs-TnI, assessed by C-statistics, was significantly greater than that of hs-CRP (0.753, 95% CI 0.735 to 0.772, vs 0.644, 95% CI 0.625 to 0.663). In conclusion, in subjects from the general population without a history of cardiovascular disease, hs-TnI provides prognostic information superior to that provided by hs-CRP and may therefore be a preferred marker for targeted prevention. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Elsevier | nb_NO |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Relative prognostic value of cardiac troponin I and C-reactive protein in the general population (from the Nord-Trøndelag Health [HUNT] Study) | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.source.pagenumber | 949-955 | nb_NO |
dc.source.volume | 121 | nb_NO |
dc.source.journal | American Journal of Cardiology | nb_NO |
dc.source.issue | 8 | nb_NO |
dc.identifier.doi | 10.1016/j.amjcard.2018.01.004 | |
dc.identifier.cristin | 1594987 | |
dc.description.localcode | © 2018. This is the authors’ accepted and refereed manuscript to the article. Locked until 2.2.2020 due to copyright restrictions. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | nb_NO |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 194,65,20,15 | |
cristin.unitcode | 194,65,25,0 | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.unitname | Helseundersøkelsen i Nord-Trøndelag | |
cristin.unitname | Institutt for sirkulasjon og bildediagnostikk | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |